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Links from GEO DataSets

Items: 19

1.
Full record GDS3705

Progressive pulmonary sarcoidosis

Comparison of lungs from patients with nodular self-limiting pulmonary sarcoidosis (PS) to those with progressive fibrotic PS. About 60-70% of patients with PS have disease that resolves spontaneously, the rest follow a chronic course. Results provide insight into the pathogenesis of progressive PS.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state sets
Platform:
GPL6244
Series:
GSE19976
15 Samples
Download data: CEL
DataSet
Accession:
GDS3705
ID:
3705
2.

Gene expression analysis of lung biopsies from patients with two different forms of pulmonary sarcoidosis

(Submitter supplied) Approximately 60-70% of patients with pulmonary sarcoidosis have a good outcome, with disease that resolves spontaneously. It is unclear why some patients progress to fibrotic disease, and there is currently no marker that differentiates these patients from those with self-limiting lung disease. Using the Affymetrix Human Gene 1.0 ST Array, we examined gene expression in lung tissue samples obtained using bronchoscopic transbronchial biopsy from 8 patients with active but self-limiting pulmonary sarcoidosis and 7 with active, progressive, fibrotic pulmonary disease. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3705
Platform:
GPL6244
15 Samples
Download data: CEL
Series
Accession:
GSE19976
ID:
200019976
3.

Genome-wide gene expression profile analysis in pulmonary sarcoidosis

(Submitter supplied) We hypothesized that tissue genome-wide gene expression analysis, coupled with gene network analyses of differentially expressed genes, would provide novel insights into the pathogenesis of pulmonary sarcoidosis. Keywords: Disease state analysis
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3580
Platform:
GPL570
12 Samples
Download data: CEL
Series
Accession:
GSE16538
ID:
200016538
4.
Full record GDS3580

Pulmonary sarcoidosis

Analysis of lungs from patients with pulmonary sarcoidosis (PS). PS is characterized by the granulomatous inflammation of the lung. Results provide insight into the molecular pathogenesis of PS.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state sets
Platform:
GPL570
Series:
GSE16538
12 Samples
Download data: CEL
5.

Expression data from fibroblasts cultured from normal and fibrotic human lung tissue

(Submitter supplied) Pulmonary fibrosis develops as a consequence of environmentally induced lung injury and/or an inherent disease susceptibility causing fibroblast activation, proliferation and extracellular matrix deposition. The study was undertaken to characterise global gene expression in pulmonary fibroblasts to better understand the mechanisms underlying the fibrotic fibroblast phenotype.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4995
Platform:
GPL96
21 Samples
Download data: CEL
Series
Accession:
GSE40839
ID:
200040839
6.
Full record GDS4995

Scleroderma-associated interstitial lung disease patients: pulmonary fibroblasts

Analysis of lung fibroblasts isolated from biopsies, taken at the time of diagnosis, from patients with well-defined pulmonary fibrosis associated with systemic sclerosis (SSc-ILD). Results provide insight into the molecular mechanisms underlying the fibrotic fibroblast phenotype in SSc-ILD.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 disease state sets
Platform:
GPL96
Series:
GSE40839
21 Samples
Download data: CEL
7.

Sarcoidosis-specific markers from whole blood gene expression

(Submitter supplied) We hypothesized that microarray analyses of whole blood gene expression would identify patterns of gene expression useful in the diagnosis for sacroidosis and identify inflammatory mediators relevant to the underlying pathophysiology.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4587
Platform:
GPL570
66 Samples
Download data: CEL
Series
Accession:
GSE19314
ID:
200019314
8.
Full record GDS4587

UCSF sarcoidosis and hypersensitivity pneumonitis cohort: peripheral blood mononuclear cells

Analysis of whole blood from sarcoidosis and hypersensitivity pneumonitis patients. Results provide insight into molecular mechanisms underlying sarcoidosis and hypersensitivity pneumonitis in peripheral blood.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 disease state sets
Platform:
GPL570
Series:
GSE19314
66 Samples
Download data: CEL
9.

Sarcoidosis + Follow-up study

(Submitter supplied) Sarcoidosis + Follow-up 6 month after Keywords = sarcoidosis Keywords = follow-up Keywords: other
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL8300 GPL91
32 Samples
Download data: CEL
Series
Accession:
GSE1907
ID:
200001907
10.

Serial Analysis of Gene Expression molecular signature for disease progression in Idiopathic Pulmonary Fibrosis

(Submitter supplied) Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrosing interstitial lung disease that is unresponsive to current therapy. While it carries a median survival of less than 3 years its rate of progression varies widely between patients. We hypothesized that studying the gene expression profiles of physiologically stable patients and those in which the disease progressed rapidly after the initial diagnosis would aid in the search for biomarkers and contribute to the understanding of disease pathogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by SAGE
Platform:
GPL4
14 Samples
Download data
Series
Accession:
GSE11665
ID:
200011665
11.

The Peripheral Blood Transcriptome Predicts the Presence and Extent of Disease in Idiopathic Pulmonary Fibrosis

(Submitter supplied) Peripheral blood biomarkers are needed to identify and determine the extent of idiopathic pulmonary fibrosis (IPF). Current physiologic and radiographic prognostic indicators diagnose IPF too late in the course of disease. These results demonstrate that the peripheral blood transcriptome can distinguish normal individuals from patients with IPF, as well as extent of disease when samples were classified by percent predicted DLCO, but not FVC.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
123 Samples
Download data: TXT
Series
Accession:
GSE33566
ID:
200033566
12.

MMP1 and MMP7 as potential peripheral blood biomarkers in Idiopathic Pulmonary Fibrosis

(Submitter supplied) Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease associated with significant morbidity and mortality. We identified a combinatorial signature of 5 proteins that was sufficient to distinguish IPF patients from controls; of these proteins MMP7 and MMP1 exhibited significantly higher values in both peripheral blood concentrations and lung tissue gene expression, suggesting their role as true biomarkers. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
46 Samples
Download data: TXT
Series
Accession:
GSE10667
ID:
200010667
13.

Gene expression profiles based on Pulmonary Artery Pressures in Pulmonary Fibrosis

(Submitter supplied) Pulmonary Hypertension (PH) is a frequent complication of Pulmonary Fibrosis (PF). PH can be seen in PF in the abscence of hypoxemia, irrespective of the degree of fibrosis. At the same time, a consistent number of patients with advanced PF never develop PH. The pathogenesis of PH secondary to PF remains unclear. PF patients are often referred to lung transplantation, but they present a higher incidence of pimary graft dysfunction than other diseases. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4549
Platform:
GPL6244
116 Samples
Download data: CEL
Series
Accession:
GSE24988
ID:
200024988
14.
Full record GDS4549

Pulmonary fibrosis with associated pulmonary hypertension: lung explants

Analysis of lung from pulmonary fibrosis (PF) patients divided into different groups based on the mean pulmonary arterial pressure (mPAP): severe pulmonary hypertension (PH) group, intermediate PH group, NoPH group. Results provide insight into the pathobiology of PF with associated PH.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 disease state sets
Platform:
GPL6244
Series:
GSE24988
116 Samples
Download data: CEL
DataSet
Accession:
GDS4549
ID:
4549
15.

Classical Hodgkin’s Lymphoma: Molecular evidence for specific alterations of circulating T lymphocytes

(Submitter supplied) Gene expression profiles were performed from CD3+ T cells isolated from peripheral blood samples of untreated patients with cHL versus 2 control groups consisting of healthy donors and patients with sarcoidosis. Keywords = Hodgkin’s Lymphoma Keywords = T cell Keywords = immune regulation Keywords: repeat sample
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1419
Platform:
GPL8300
6 Samples
Download data
Series
Accession:
GSE2657
ID:
200002657
16.
Full record GDS1419

Classical Hodgkin's lymphoma: T cell expression profile

Expression profiling of CD3+ T cells isolated from peripheral blood samples of untreated patients with classical Hodgkin's lymphoma. CD3+ T cells from healthy donors and patients with sarcoidosis also examined.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 disease state sets
Platform:
GPL8300
Series:
GSE2657
6 Samples
Download data
DataSet
Accession:
GDS1419
ID:
1419
17.

Gene expression in human orbit

(Submitter supplied) Diagnosis of inflamed human orbit tissue with standard clinical and histopathology evaluation data is imprecise. A large number of these patients are diagnosed with the catch-all classification of nonspecific orbital inflammation (NSOI). We utilized gene expression analysis of orbit biopsies to assist in the classification of sarcoidosis, granulomatosis with polyangiitis (GPA), thyroid eye disease (TED), IgG4-associated disease, and subdivisions of NSOI. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
175 Samples
Download data: CEL
Series
Accession:
GSE58331
ID:
200058331
18.

Genomic Phenotype Of Non-Cultured IPF Fibroblasts

(Submitter supplied) The activated fibroblast is the central effector cell for the progressive fibrotic process that characterizes idiopathic pulmonary fibrosis (IPF). An understanding of the genomic phenotype of this cell in isolation is essential to the understanding of disease pathogenesis and is integral to strategizing therapeutic trials. Employing a unique technique that minimizes cellular phenotypic alterations, we characterized the genomic phenotype of non-cultured pulmonary fibroblasts from the lungs of patients with advanced IPF. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8903
58 Samples
Download data: GPR, MEV, TXT
Series
Accession:
GSE17978
ID:
200017978
19.

Global Gene Expression Profiles of Fibroblasts from the Lungs of Patients with Idiopathic Pulmonary Fibrosis: The Role of CCL8

(Submitter supplied) Analysis of Idiopathic pulmonary fibrosis (IPF) at gene expression level. The hypothesis tested in the present study was that Epigenetic mechanisms are likely to be associated with pathogenesis in IPF. To determine the DNA methylation change, and their effects on gene expression, we compared microarray data of DNA methylation and RNA expression. Results provide that among the genes whose DNA methylation status and RNA expression were both significantly altered between IPF-rapid and normal controls.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
12 Samples
Download data: IDAT
Series
Accession:
GSE71351
ID:
200071351
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