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Links from GEO DataSets

Items: 20

1.
Full record GDS3685

Livers with Dicer1 deficient hepatocytes

Analysis of liver with hepatocytes lacking Dicer1. Dicer1 is an RNaseIII-type enzyme that cleaves both long double-stranded RNA molecules and hairpin miRNA precursors, and it is required for the processing of all miRNAs. Results provide insight into the function of Dicer1 in the liver.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE11899
10 Samples
Download data: CEL
2.

Gene expression in Dicer-deficient mouse liver

(Submitter supplied) Background & Aims: MiRNAs are small (~22 nucleotide), non-coding RNA molecules that regulate gene expression through imperfect complementarity with target messenger RNAs. The function of miRNA in mammalian organogenesis is largely unknown. Conditional loss-of-function of Dicer, the enzyme that processes precursor miRNA transcripts into their mature, active form, has been shown to cause severe defects in a number of organ systems. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3685
Platform:
GPL1261
10 Samples
Download data: CEL
Series
Accession:
GSE11899
ID:
200011899
3.

DICER1 hotspot mutations cause defective miRNA processing

(Submitter supplied) Recurrent somatic hotspot mutations of DICER1 appear to be clustered around each of four critical metal binding residues in the RNase IIIB domain of DICER1. This domain is responsible for cleavage of the 3’ end of the 5p-miRNA strand of a pre-mRNA hairpin. To investigate the effects of these cancer-associated “hotspot” mutations we engineered mouse Dicer1-deficient ES cells to express wild-type and an allelic series of the mutant human DICER1 variants. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
28 Samples
Download data: CEL
Series
Accession:
GSE40965
ID:
200040965
4.

Biochemical Identification of Targets of Individual MicroRNAs in Mouse Embryonic Stem Cells

(Submitter supplied) Mouse Embryonic Stem (ES) cells express a unique set of microRNAs (miRNAs), the miR-290-295 cluster. To elucidate the role of these miRNAs and how they integrate into the ES cell regulatory network requires identification of their direct regulatory targets. The difficulty, however, arises from the limited complementarity of metazoan miRNAs to their targets, with the interaction requiring as few as six nucleotides of the miRNA seed sequence. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL10010
10 Samples
Download data: TXT
5.

Genome-wide Identification of Targets & Function of Individual MicroRNAs in Mouse Embryonic Stem Cells

(Submitter supplied) Mouse Embryonic Stem (ES) cells express a unique set of microRNAs (miRNAs), the miR-290-295 cluster. To elucidate the role of these miRNAs and how they integrate into the ES cell regulatory network requires identification of their direct regulatory targets. The difficulty, however, arises from the limited complementarity of metazoan miRNAs to their targets, with the interaction requiring as few as six nucleotides of the miRNA seed sequence. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
6 Samples
Download data: TXT
Series
Accession:
GSE20048
ID:
200020048
6.

Gene expression profile of Dicer-deficient oocytes

(Submitter supplied) Small RNAs, such as miRNAs and siRNAs, are involved in gene regulation in a variety of systems, including mouse oocytes. Dicer is a ribonuclease III enzyme essential for miRNA and siRNA biosynthesis. In an effort to uncover the function of small RNAs during oocyte growth, we specifically deleted Dicer in growing oocytes and analyzed the global pattern of gene expression in these Dicer-deficient oocytes.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE17985
ID:
200017985
7.

Gene expression profiles of DKO172 cells expressing DICER1 wildtype or hotspot mutants

(Submitter supplied) DICER1 plays a critical role in microRNA (miRNA) biogenesis. Recurrent somatic “hotspot” mutations at four mental binding sites within the RNase IIIb domain of DICER1, were identified in ovarian sex cord-stromal tumors and have since been described in other pediatric tumors. In this study, we identified and characterized DICER1 hotspot mutations in endometrial cancers derived from The Cancer Genome Atlas (TCGA) and our local tumor bank. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
12 Samples
Download data: TXT
Series
Accession:
GSE65092
ID:
200065092
8.

Proliferation and Tumorigenesis of a Murine Sarcoma Cell Line in the Absence of Dicer

(Submitter supplied) MicroRNAs are a class of short ~22 nucleotide RNAs predicted to regulate nearly half of all protein-coding genes, including many involved in basal cellular processes and organismal development. Although both increases and decreases in the levels of specific miRNAs have been shown to promote tumor development, a global reduction in miRNAs is commonly observed in various human tumors. However, complete loss has not been documented, suggesting an essential function for miRNAs in tumorigenesis. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL9250
2 Samples
Download data
Series
Accession:
GSE34825
ID:
200034825
9.

Deregulated sex chromosome gene expression with male germ cell-specific loss of Dicer1

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL15733 GPL15734
11 Samples
Download data: CEL
Series
Accession:
GSE38896
ID:
200038896
10.

Deregulated sex chromosome gene expression with male germ cell-specific loss of Dicer1 (miRNA array data)

(Submitter supplied) MicroRNAs (miRNAs) are a class of endogenous, non-coding RNAs that mediate post-transcriptional gene silencing by inhibiting mRNA translation and promoting mRNA decay. DICER1, an RNAse III endonuclease encoded by Dicer1, is required for processing short 21-22 nucleotide miRNAs from longer double-stranded RNA precursors. Here, we investigate the loss of Dicer1 in mouse postnatal male germ cells to determine how disruptions in the miRNA biogenesis pathway may contribute to infertility. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL15734
5 Samples
Download data: TXT
Series
Accession:
GSE38895
ID:
200038895
11.

Deregulated sex chromosome gene expression with male germ cell-specific loss of Dicer1 (gene array data)

(Submitter supplied) MicroRNAs (miRNAs) are a class of endogenous, non-coding RNAs that mediate post-transcriptional gene silencing by inhibiting mRNA translation and promoting mRNA decay. DICER1, an RNAse III endonuclease encoded by Dicer1, is required for processing short 21-22 nucleotide miRNAs from longer double-stranded RNA precursors. Here, we investigate the loss of Dicer1 in mouse postnatal male germ cells to determine how disruptions in the miRNA biogenesis pathway may contribute to infertility. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL15733
6 Samples
Download data: CEL, TXT
Series
Accession:
GSE38891
ID:
200038891
12.

Gene Expression in Mutant P0 Cre Dicer Mouse Sciatic Nerves

(Submitter supplied) The hypothesis is that genes involved in the immature schwann cell and promyelinating state will be upregulated and genes that are involved in the myelnating state will be down regulated.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
6 Samples
Download data
Series
Accession:
GSE16741
ID:
200016741
13.

Analysis of the global retinal transcriptome of rod photoreceptor-specific Dicer1 conditional knockout mice and control littermates

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL16173 GPL17021
12 Samples
Download data
Series
Accession:
GSE55393
ID:
200055393
14.

RNAseq analysis of the global retinal transcriptome of rod photoreceptor-specific Dicer1 conditional knockout mice and control littermates

(Submitter supplied) We report RNAseq analysis of the transcriptome of retinas from mature rod-specific Dicer1 cKO mice and control littermates lacking Cre expression in order to better understand changes in gene regulation that could lead to retinal degeneration in cKO mice.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16173
6 Samples
Download data: TXT
Series
Accession:
GSE55377
ID:
200055377
15.

small RNAseq analysis of the global retinal transcriptome of rod photoreceptor-specific Dicer1 conditional knockout mice and control littermates

(Submitter supplied) We report RNAseq analysis of the transcriptome of retinas from mature rod-specific Dicer1 cKO mice and control littermates lacking Cre expression in order to better understand changes in gene regulation that could lead to retinal degeneration in cKO mice.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: TXT
Series
Accession:
GSE55376
ID:
200055376
16.

Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination

(Submitter supplied) The myelin sheaths that surround the thick axons of the peripheral nervous system are produced by the highly specialized Schwann cells. Differentiation of Schwann cells and myelination occur in discrete steps. Each of these requires coordinated expression of specific proteins in a precise sequence, yet the regulatory mechanisms controlling protein expression during these events are incompletely understood. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL10384
16 Samples
Download data: TXT
Series
Accession:
GSE22023
ID:
200022023
17.

Mouse embryonic fibroblast (MEF) cells after 2, 3 or 4 days of inducible genetic deletion of Dicer1

(Submitter supplied) To investigate the suitable normalization for miRNA arrays from samples with global miRNA decrease. Our comparisons of five preprocess steps performed at the probe level demonstrated that the use of cyclic loess relying on non-miRNA small RNAs present on the Affymetrix platform significantly improved specificity and sensitivity of detection of decreased miRNAs.
Organism:
Mus musculus; synthetic construct
Type:
Non-coding RNA profiling by array
Platform:
GPL8786
9 Samples
Download data: CEL
Series
Accession:
GSE45886
ID:
200045886
18.

Dicer1 imparts essential survival cues in Notch driven T-ALL via miR-21 mediated tumor suppressor Pdcd4 repression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Non-coding RNA profiling by array
Platforms:
GPL19324 GPL20161
19 Samples
Download data: TXT
Series
Accession:
GSE68635
ID:
200068635
19.

Mouse primary T-ALL microRNA microarray

(Submitter supplied) Primary mouse cells (CD4-CD8- (DN) and CD4+CD8+ (DP) thymus and T-ALL (early-stage - ES and late-stage - LS) and mouse T-ALL cell line M295 were assessed for microRNA expression
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL19324
13 Samples
Download data: TXT
Series
Accession:
GSE68634
ID:
200068634
20.

microRNA expression in CUTLL1 cells

(Submitter supplied) T-ALL cell line CUTLL1 was assessed for microRNA expression. Cells were treated with DMSO (ctr) or DAPT (10uM) to inhibit Notch1 cleavage for 3d and then harvested.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL20161
6 Samples
Download data: TXT
Series
Accession:
GSE68612
ID:
200068612
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