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Links from GEO DataSets

Items: 11

1.
Full record GDS3677

High-fat-diet model: liver

Analysis of liver from obesity-prone (OP) Wistar males with nonalcoholic fatty liver disease (NAFLD) induced by a 16 week, high-fat diet (HFD). Obesity-resistant (OR) males, fed an identical diet, were also examined. Results provide insight into molecular mechanisms underlying NAFLD pathogenesis.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, log ratio, 2 disease state sets
Platform:
GPL4294
Series:
GSE11492
8 Samples
Download data: TXT
DataSet
Accession:
GDS3677
ID:
3677
2.

Transcript Profiling of High Fat Diet induced Obesity-prone and Obesity-resistant Rats

(Submitter supplied) Rodents respond to chronic high fat diet in at least two ways: some of them may readily gain body weight and become obese (termed obesity-prone), and others may not (termed obesity-resistant). An integrated approach of transcript and metabolic profiling of obesity-prone and obesity-resistant rats has been conducted, showing significantly different transcript and metabolic profiles in the two phenotypes. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3677
Platform:
GPL4294
8 Samples
Download data: TXT
Series
Accession:
GSE11492
ID:
200011492
3.

Orotic acid induced fatty liver disease

(Submitter supplied) A time course of orotic acid induced fatty liver disease. Kyoto and Wistar strain rats were exposed to orotic acid for days 1, 3 and 14. Controls are also included. Keywords = Wistar Keywords = Kyoto Keywords = orotic acid Keywords: time-course
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS765
Platform:
GPL85
14 Samples
Download data
Series
Accession:
GSE665
ID:
200000665
4.
Full record GDS765

Fatty liver disease induced by orotic acid: time course

Expression profiling of livers from inbred Kyotos and outbred Wistars fed a diet with 1% orotic acid to induce fatty liver disease. Profiles examined at various time points up to 14 days. Results used together with NMR spectroscopic analysis of the liver to identify perturbed metabolic pathways.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 2 strain, 4 time sets
Platform:
GPL85
Series:
GSE665
18 Samples
Download data
DataSet
Accession:
GDS765
ID:
765
5.

Gene expression profiles of rat liver tissues after high-fat emulsion feeding

(Submitter supplied) Nonalcoholic fatty liver disease (NAFLD) is a common disorder characterized by excessive hepatic fat accumulation, and potentially resulting in non-alcoholic steatohepatitis (NASH), liver cirrhosis (LC) and end-stage liver disease We used Rat Genome 230 2.0 microarray to further highlight the rat liver tissues after high-fat emulsion feeding.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
12 Samples
Download data: CEL, CHP, XLS
Series
Accession:
GSE73500
ID:
200073500
6.

Effect of a High Phosphorus Diet on Hepatic Gene Expressions in Rat

(Submitter supplied) A high phosphorus (HP) diet causes disorders of renal function, bone metabolism, and vascular function. We previously demonstrated that DNA microarray analysis is an appropriate method to comprehensively evaluate the effects of a HP diet on kidney dysfunction such as calcification, fibrillization, and inflammation. We reported that type IIb sodium-dependent phosphate transporter is significantly up-regulated in this context. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
8 Samples
Download data: CEL
Series
Accession:
GSE71201
ID:
200071201
7.

The effect of mequindox on gene expression in rat liver tissue

(Submitter supplied) Veterinary drug mequindox, 3-methyl-2-acethyl-quindoxaline-N-1,4-dioxide, belongs to a class of antibiotic and growth-prompting drug called quinoxalines that are often used in livestock and poultry industry. Previous researches focused on traditional toxicity. However, the effect of mequindox on endogenous metabolic profile remains unknown. We used microarrays to detail the global programme of gene expression underlying mequindox toxicity.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
11 Samples
Download data: CEL
Series
Accession:
GSE30935
ID:
200030935
8.

Transcriptome analysis of garlic induced hepatoprotection against alcoholic fatty liver

(Submitter supplied) Alcohol induced fatty liver cause a dangerous health problem and is the major cause of morbidity and mortality worldwide. Garlic (Allium sativum) is documented to possess anti-fatty liver properties. However the exact molecular mechanisms are unknown. The main aim of this experiment is to elucidate the underlying pathways through which garlic ameliorates alcohol induced fatty liver. Dially disulfide and garlic oil were the garlic compounds used in this study. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
16 Samples
Download data: TXT
Series
Accession:
GSE40334
ID:
200040334
9.

Expression data from livers of C57BL/6J mice fed a high-fat diet and coffee

(Submitter supplied) The present study was conducted to evaluate the effects of the intake of three types of coffee (caffeinated, decaffeinated, and green unroasted coffee) on the livers of C57BL/6J mice fed a high-fat diet, and to extensively elucidate the physiological responses to coffee intake by analysing the findings obtained from a comprehensive transcriptomic analysis using DNA microarrays. The present study was conducted to evaluate the effects of the intake of three types of coffee (caffeinated, decaffeinated, and green unroasted coffee) on the livers of C57BL/6J mice fed a high-fat diet, and to extensively elucidate the physiological responses to coffee intake by analysing the findings obtained from a comprehensive transcriptomic analysis using DNA microarrays.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
15 Samples
Download data: CEL
Series
Accession:
GSE53131
ID:
200053131
10.

Identification and Differential Expression of MicroRNAs Associated with Fat Deposition in Wistar Rat Liver Using Solexa Sequencing

(Submitter supplied) we analyzed the miRNAs expression in Wistar rat liver tissues, High glucose (HG)-induced NAFLD Wistar rats (NAFLD group, n=3) and normal Wistar rats (normal group, n=3). Results provided the first global miRNAs in the NAFLD Wistar rat livers, and expanded the miRNAs repertoire in normal Wistar rat livers, which should be useful for further investigation into the biological functions and evolution of miRNAs in rats and other species. more...
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL14844
6 Samples
Download data: TXT
Series
Accession:
GSE68411
ID:
200068411
11.

Expression data from an outbred model for type 2 diabetes development

(Submitter supplied) To study the development mechanisms of type 2 diabetes, we examined multi-tissues' expression profiles of outbred mice fed with a high-fat diet (HFD) or regular chow at week 1, 9, and 18 and performed a novel dual eigen-analysis.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
62 Samples
Download data: CEL
Series
Accession:
GSE77943
ID:
200077943
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