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Links from GEO DataSets

Items: 13

1.
Full record GDS3558

Deferasirox effect on leukemia cell line: dose response

Analysis of leukemia K562 cells treated with 10 or 50 uM deferasirox. Deferasirox is an iron chelator taken orally to treat iron toxicity. Iron depletion by deferasirox inhibits cancer cell proliferation in vitro. Results provide insight into the molecular basis of this anti-proliferative effect.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 3 dose sets
Platform:
GPL570
Series:
GSE11670
6 Samples
Download data: CEL
DataSet
Accession:
GDS3558
ID:
3558
2.

Transcriptional profiling of ICL670 treated K562 cells

(Submitter supplied) Iron plays a central role in the regulation of many cellular functions. Dysregulation of its metabolism leads an iron overload situation and iron depletion leads to an inhibition of cell proliferation. Recent reports demonstrated that ICL670 (Novartis) acts as a potent NF-kappa-B inhibitor and improves hematological data in a subset of MDS patients (Cilloni et al, Haematologica, s1: 238, 2007). However, the precise mechanism of anti-cancer effect of ICL670 is still uncertain. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3558
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE11670
ID:
200011670
3.

Effect of iron chelators on global gene expression pattern in SW480 cells

(Submitter supplied) Gene expression analysis of SW480 cells treated with inhibitor compounds for 6 hours. Results provide insights into the role of iron in Wnt signalling and demonstrate that iron depletion is the primary mode of actions of these compounds on Wnt pathway.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
13 Samples
Download data: CEL
Series
Accession:
GSE32369
ID:
200032369
4.

Investigation of gene expression alterations of pancreatic cancer caused by Deferasirox administration

(Submitter supplied) To investigate the genetic effect of Deferasirox in pancreatic cancer, we examined gene expression alternations in the removed tumors exposed to Deferasirox.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
6 Samples
Download data: TXT
Series
Accession:
GSE81363
ID:
200081363
5.

AKT_Prostate_RAD001_v_PLACEBO

(Submitter supplied) Transgenic (Probasin driven Myr-AKT)or wild-type littermates were treated with RAD001 or placebo and sacrificed at 12 and 48 hours following the beginning of treatment Keywords = AKT Prostate RAD001 mTOR PIN Keywords: time-course
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL339
38 Samples
Download data: CEL
Series
Accession:
GSE1413
ID:
200001413
6.

profiling of C/EBP targets

(Submitter supplied) The zinc-inducible C/EBP expression vectors pMTa, pMTb, pMTd and pMTe were constructed by cloning the human C/EBPa, C/EBPb, C/EBPd and C/EBPe cDNAs, respectively, into the pMTCB6+ vector. NIH 3T3 cells were transfected with zinc-inducible C/EBP vectors as well as control empty vector using the GenePORTER™ transfection Reagent (GTS Inc.). Multiple polyclonal clones were obtained by selection with G418 (700 mg/ml). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1872
Platform:
GPL81
15 Samples
Download data
Series
Accession:
GSE2188
ID:
200002188
7.
Full record GDS1872

CCAAT/enhancer-binding proteins C/EBP alpha, beta, delta, and epsilon induction

Analysis of NIH 3T3 cells following induction of CCAAT/enhancer-binding protein (C/EBP) alpha, beta, delta, or epsilon from zinc inducible expression vectors. The C/EBP family of transcription factors regulate growth and differentiation in numerous cell types. Results identify C/EBP targets.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 5 agent sets
Platform:
GPL81
Series:
GSE2188
15 Samples
Download data
8.

Transcriptome and translatome profiling of CPX 90m effects in neuroblastoma cells CHP134

(Submitter supplied) Neuroblastoma (NB) is the most frequent extracranial solid tumour of childhood. Clinical courses are highly variable, ranging from spontaneous regression/maturation to rapid progression despite intensive multimodal therapy. The estimation of 5-year event free survival in high-risk patients of only about 40 % stresses an importance of novel therapeutic strategies. A number of iron chelators have demonstrated marked in vitro and in vivo anti-tumor activity and are currently being developed as novel anti-cancer agents. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
12 Samples
Download data: TXT
Series
Accession:
GSE60675
ID:
200060675
9.

Expression Profile of CREB knockdown in Myeloid Leukemia Cells

(Submitter supplied) Background. The cAMP Response Element Binding Protein, CREB, is a transcription factor that regulates cell proliferation, differentiation, and survival in several model systems, including neuronal and hematopoietic cells. We demonstrated that CREB is overexpressed in acute myeloid and leukemia cells compared to normal hematopoietic stem cells. CREB knockdown inhibits leukemic cell proliferation in vitro and in vivo, but does not affect long-term hematopoietic reconstitution. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3487
Platform:
GPL570
20 Samples
Download data: CEL
Series
Accession:
GSE12056
ID:
200012056
10.
Full record GDS3487

Transcription factor CREB depletion effect on myeloid leukemic cell line

Analysis of myeloid leukemia K562 cells depleted for cAMP Response Element Binding Protein (CREB), a transcription factor. CREB is overexpressed in bone marrow samples of patients with acute leukemia. Results provides insight into the molecular mechanisms by which CREB contributes to acute leukemia.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL570
Series:
GSE12056
20 Samples
Download data: CEL
11.

Gene expression from Mouse Embryonic Fibroblasts

(Submitter supplied) Gene expression from Wild-type and NFAT5 knock-out Mouse Embryonic Fibroblasts keywords: Mouse Embryonic Fibroblasts
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
18 Samples
Download data: CEL
Series
Accession:
GSE27485
ID:
200027485
12.

REDD1 (regulated in development and DNA damage response 1) dissociates therapeutic and adverse effects of topical steroids in skin

(Submitter supplied) Even though cutaneous atrophy is the major adverse effect of topical glucocorticoids, its molecular mechanisms are poorly understood. We found that glucocorticoids strongly increased the expression of REDD1 (regulated in development and DNA damage response 1), a stress-inducible inhibitor of mTOR, in mouse and human epidermis. We found that REDD1 knockout animals are partially resistant to glucocorticoid-induced epidermal and subcutaneous adipose atrophy which correlated with the protection of CD34+ follicular epithelial stem cells as well as p63+ keratinocyte progenitors in REDD1 knockout epidermis during chronic steroid treatment. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
8 Samples
Download data: TXT
Series
Accession:
GSE59151
ID:
200059151
13.

Network analysis of gene expression in mice provides new evidence of involvement of the mTOR pathway in antipsychotic-induced extrapyramidal symptoms

(Submitter supplied) To identify potential candidate genes for future pharmacogenetic studies of antipsychotic (AP)-induced extrapyramidal symptoms (EPS), we used gene expression arrays to analyze changes induced by risperidone in mice strains with different susceptibility to EPS This study is a part of a convergent functional genomic approach that plans to integrate the data presented here with: data from gene expression analysis of neuroblastoma cell line under treatment with risperidone; and data from gene expression analysis of peripheral blood from first psychotic patients treated with risperidone.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11180
16 Samples
Download data: CEL
Series
Accession:
GSE67723
ID:
200067723
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