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Items: 2

1.
Full record GDS3471

B-precursor acute lymphoblastic leukemia tumors sensitive and resistant to ionizing radiation

Analysis of B-precursor acute lymphoblastic (ALL) tumor cells exposed to ionizing radiation (IR) to induce DNA damage in vitro. Half of the tumors are sensitive to IR induced apoptosis. Results provide insight into the molecular basis of the differences in response of B-precursor ALL to IR.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 disease state, 22 individual sets
Platform:
GPL96
Series:
GSE13280
44 Samples
Download data: CEL
DataSet
Accession:
GDS3471
ID:
3471
2.

Gene expression analysis of paediatric acute lymphoblastic leukaemia

(Submitter supplied) We addressed the clinical significance and mechanisms behind in vitro cellular responses to ionising radiation (IR)-induced DNA double strand breaks in 74 paediatric ALL patients. We found an apoptosis-resistant response in 36% of patients and an apoptosis-sensitive response in the remaining 64% of leukaemias. Global gene expression profiling of 11 apoptosis-resistant and 11 apoptosis-sensitive ALLs revealed abnormal up-regulation of multiple pro-survival pathways in response to IR in apoptosis-resistant leukaemias and differential post-transcriptional activation of the PI3-Akt pathway was observed in representative resistant cases. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3471
Platform:
GPL96
44 Samples
Download data: CEL
Series
Accession:
GSE13280
ID:
200013280

Supplemental Content

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