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Links from GEO DataSets

Items: 3

1.
Full record GDS2915

Aging liver

Analysis of livers of Fisher F344/N males at 32, 58, and 84 weeks of age. Results provide insight into age-associated changes in the capacity of the liver to metabolize xenobiotic compounds.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, log ratio, 3 age sets
Platform:
GPL890
Series:
GSE4270
38 Samples
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DataSet
Accession:
GDS2915
ID:
2915
2.

Aging Induced Alterations in Hepatic Gene Expression of the Male Fisher Rat

(Submitter supplied) Toxicokinetic and metabolism studies are considered crucial to dose setting and interpretation of data from rodent carcinogenicity studies. The metabolism and distribution studies are usually conducted in 6 to 8 week old rodents. However cancer studies generally involve exposures from 6 weeks of age to 108 weeks or more of age. It is recognized that age-related differences in sensitivities to some xenobiotics occur in several rodent models including the rat. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS2915
Platform:
GPL890
38 Samples
Download data
Series
Accession:
GSE4270
ID:
200004270
3.

Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344

(Submitter supplied) In order to gain insight into the effects of aging on susceptibility to environmental toxins, we characterized the expression of xenobiotic metabolizing enzymes (XMEs) from the livers of male Brown Norway and F344 rats across the adult lifespan. To examine metabolic processes across lifespan after challenge with a xenobiotic compound, Brown Norway rats were exposed to 1.0 g/kg body weight toluene by oral gavage in corn oil (4ml/kg body weight) or corn oil alone. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
34 Samples
Download data: CEL
Series
Accession:
GSE11097
ID:
200011097
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