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Links from GEO DataSets

Items: 9

1.

Head and neck paragangliomas

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; SNP genotyping by SNP array; Non-coding RNA profiling by array
Platforms:
GPL8179 GPL17539
72 Samples
Download data
Series
Accession:
GSE49615
ID:
200049615
2.

High-density genome-wide copy number variation (CNV) in human head and neck paragangliomas.

(Submitter supplied) Gene-centric CNV analysis of 24 individual paraganglioma cases identified a list of 104 genes most significantly targeted by tumor-associated alterations. The NOTCH signaling pathway was the most significantly enriched term in the list. Overexpression of the relevant NOTCH pathway proteins in sustentacular (glial), chief (neuroendocrine) and endothelial cells was confirmed by immunomorphological studies in 47 paragangliomas, including CNV-tested cases. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; SNP genotyping by SNP array
Platform:
GPL17539
51 Samples
Download data: TXT
Series
Accession:
GSE49614
ID:
200049614
3.

Genome-wide analysis of the miR profile in human head and neck paraganglioma vs. Jacobson's (tympanic) nerve and SH-SY5Y neuroblastoma cells

(Submitter supplied) The aim of the study was to assess whether changes in the expression of miRs could be implicated in the modulation of the NOTCH pathway in head and neck paragangliomas. Several miRs, notably including families (miR-34s, miR-200s) that target the NOTCH signaling pathway, resulted differentially expressed in paragangliomas compared to the reference normal tissue, i.e., Jacobson's nerve.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL8179
21 Samples
Download data: TXT
Series
Accession:
GSE49190
ID:
200049190
4.

Cancer Outlier Gene Profile Sets Elucidate Pathways and Patient-Specific Targets in Head and Neck Squamous Cell Carcinoma [Affymetrix HuEx1.0]

(Submitter supplied) This study integrated Affymetrix SNPchip data for CNV estimation, Affymetrix HuEx1.0 data for gene expression estimation, and Illumina HumanMethylation27k BeadChip data for promoter methylation to estimate pathway activity
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5175
69 Samples
Download data: CEL
Series
Accession:
GSE33205
ID:
200033205
5.

MIRnome Profiling of Hereditary Pheochromocytoma and Paraganglioma Reveals Specific Signatures According to Primary Mutation: Possible Implications in the Differentiation Status of Tumor Cells

(Submitter supplied) Pheochromocytoma (PCC) and paraganglioma (PGL) are rare neuroendocrine neoplasias of neural crest origin. They can be part of several syndromes, and their mRNA profile is dependent on genetic background, but questions related to clinical behavior or even main location remain unanswered. MicroRNAs are key modulators of target genes through translational repression, mRNA degradation, or both, and therefore they could resolve some of these issues. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL8227
54 Samples
Download data: TXT
Series
Accession:
GSE29742
ID:
200029742
6.

Genome-scale DNA methylation maps of mouse chromaffin cells with or without Sdhb knock-out.

(Submitter supplied) We report the analysis of DNA methylation in mouse chromaffin cell lines using reduced representation bisulfite sequencing (RRBS). We compared DNA methylation profiles of cell lines with or without a knock-out of Sdhb gene, showing that Sdhb disruption results in a hypermethylator phenotype.
Organism:
Mus musculus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL13112
4 Samples
Download data: BED
Series
Accession:
GSE44350
ID:
200044350
7.

Genome-scale methylome profiling of human pheochromocytomas and paragangliomas (Illumina methylation beadchips) and mouse chromaffin cells (RRBS)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Methylation profiling by array; Methylation profiling by high throughput sequencing
Platforms:
GPL13112 GPL8490 GPL13534
176 Samples
Download data: BED
Series
Accession:
GSE43298
ID:
200043298
8.

Genome-scale methylome profiling of pheochromocytomas and paragangliomas with Illumina HumanMethylation450 arrays

(Submitter supplied) Genome-scale DNA methylation was analyzed in a cohort of paragangliomas to identify DNA methylation changes.
Organism:
Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL13534
24 Samples
Download data: TXT
Series
Accession:
GSE43293
ID:
200043293
9.

Genome-scale methylome profiling of pheochromocytomas and paragangliomas with Illumina Infinium 27k Human Methylation arrays

(Submitter supplied) Genome-scale DNA methylation was analyzed in a large cohort of pheochromocytomas and paragangliomas (PCC/PGL). Consensus clustering identified 3 stable clusters significantly associated with expression subgroups, gene mutations, and clinical parameters.
Organism:
Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL8490
148 Samples
Download data: TXT
Series
Accession:
GSE39198
ID:
200039198
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