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Links from GEO DataSets

Items: 12

1.

Smoking and Obesity Related Molecular Alterations in Clear Cell Renal Cell Carcinoma

(Submitter supplied) Both cigarette smoking and obesity have been implicated in increased risk of clear cell renal cell carcinoma (ccRCC); however, there are limited data regarding the molecular mechanisms that underlie these associations. We used a multi-stage design to identify and validate specific molecular targets that are associated with smoking or obesity-related ccRCC.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
130 Samples
Download data: CEL
Series
Accession:
GSE46699
ID:
200046699
2.

Gene expression in Stage 1,2 Normal and Tumor kidney cancer

(Submitter supplied) Although renal cell carcinoma (RCC) is the sixth-leading cause of cancer death, the molecular events leading to disease onset and progression are not well understood. Genomic profiling of clear cell RCC (cRCC) patients indicated that loss of a negative regulator of the Wnt pathway, secreted frizzled-related protein 1 (sFRP1), occurred in the majority of more than 100 patients tested. To our knowledge, this is the first report of loss of sFRP1 expression in patients diagnosed with cRCC; this loss occurs in early stage cRCC, suggesting that it may be an important early event in renal carcinogenesis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS2880 GDS2881
Platforms:
GPL96 GPL97
40 Samples
Download data: CEL, PDF, TXT, ZIP
Series
Accession:
GSE6344
ID:
200006344
3.
Full record GDS2881

Clear cell renal cell carcinoma (HB-U133B)

Analysis of patient matched normal and stage 1 or stage 2 clear cell renal cell carcinoma (cRCC) tumors. Results provide insight into the molecular pathogenesis of cRCC.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 disease state, 10 individual sets
Platform:
GPL97
Series:
GSE6344
20 Samples
Download data: CEL
4.
Full record GDS2880

Clear cell renal cell carcinoma (HG-U133A)

Analysis of patient matched normal and stage 1 or stage 2 clear cell renal cell carcinoma (cRCC) tumors. Results provide insight into the molecular pathogenesis of cRCC.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 disease state, 10 individual sets
Platform:
GPL96
Series:
GSE6344
20 Samples
Download data: CEL
5.

Gene expression characterization of high and low grade clear cell renal cell carcinoma

(Submitter supplied) Patients undergoing either partial or radical nephrectomy at William Beaumont Hospital (Royal Oak, MI) were consented prior to surgery with local IRB oversight. Samples were collected at time of surgery and stored at -80°C according to CAP (College of American Pathologist)-accredited standard operating procedures. Disease pathology of frozen samples was validated with hematoxylin and eosin stained tissue sections from adjacently collected formalin fixed paraffin embedded tissue. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
49 Samples
Download data: CEL
Series
Accession:
GSE68417
ID:
200068417
6.

Global analysis of metastasis-associated gene expression in the primary cultures from clinical specimens of ccRCC

(Submitter supplied) Metastatic clear cell renal cell carcinoma (ccRCC) has a poor prognosis and unpredictable course and there are no molecular markers that reliably predict ccRCC metastasis. In this study, specimens from 84 patients with ccRCC were directly cultured in vitro. The primary cultures from 38 of 94 specimens contained more than 90% tumor cells at 4th passages. After identified by immunostaining, the primary cultures of metastatic- and nonmetastatic ccRCC specimens from the age-, gender-matched patients were subjected to cDNA microrray assays. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6259
12 Samples
Download data: TXT
Series
Accession:
GSE11072
ID:
200011072
7.

Meta-analysis of Clear Cell Renal Cell Carcinoma Gene Expression Defines a Variant Subgroup and Identifies Gender Influences on Tumor Biology

(Submitter supplied) Clear cell renal cell carcinoma comprises two dominant subtypes, ccA and ccB, with gender disparity providing additional disease information. A third minor subgroup has distinct expression profiles consistent with von Hippel-Lindau wild type status and displays variant histology features.
Organism:
Homo sapiens
Type:
Expression profiling by array; Third-party reanalysis
Platform:
GPL4133
44 Samples
Download data: TXT
Series
Accession:
GSE33093
ID:
200033093
8.

Identification of metastasis associated genes in clear cell renal cell carcinoma

(Submitter supplied) This study investigates the genes that promote clear cell renal cell carcimoma (ccRCC) metastasis using 4 primary metastatic and 5 non-metastatic tumor samples. U133 plus 2.0 array was used to identify the diffrently expressed genes between the primary metastatic and non metastatic ccRCC samples
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
9 Samples
Download data: CEL
Series
Accession:
GSE47352
ID:
200047352
9.

Patterns of gene expression and copy-number alterations in VHL disease-associated and sporadic ccRCC

(Submitter supplied) Recent insights into the role of the VHL tumor suppressor gene in hereditary and sporadic clear cell carcinoma of the kidney (ccRCC) have led to new treatments for patients with metastatic ccRCC, although virtually all patients eventually succumb to the disease. We performed an integrated, genome-wide analysis of copy-number changes and gene expression profiles in 90 tumors, including both sporadic and VHL disease-associated tumors, in hopes of identifying new therapeutic targets in ccRCC. more...
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by SNP array
Platforms:
GPL3720 GPL3921
229 Samples
Download data: CEL
Series
Accession:
GSE14994
ID:
200014994
10.

Genome-wide analysis of differentially expressed genes and splicing isoforms in clear cell Renal Cell Carcinoma

(Submitter supplied) In this study we performed a genome wide analysis of the entire complement of mRNAs in clear cell renal cell carcinomas (ccRCC) by means of the Affymetrix Exon Array platform. The analyses were performed both at gene and exon level. Under our parameters over 2,000 genes resulted differentially expressed, and about 250 genes resulted alternative spliced showing differential inclusion of specific cassette exons comparing tumor and non tumoral tissues.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL5188 GPL5175
40 Samples
Download data: CEL
Series
Accession:
GSE47032
ID:
200047032
11.

Gene array analysis of clear cell renal cell carcinoma tissue versus matched normal kidney tissue

(Submitter supplied) Currently there is a lack of effective therapies which result in long-term durable response for patients presenting with advanced and metastatic clear cell renal cell carcinoma (ccRCC). This is due in part to a lack of molecular factors which can be targeted pharmacologically. In order to identify novel tumor-specific targets, we performed high throughput gene array analysis screening numerous patient ccRCC tumor tissues across all stages of disease, and compared their gene expression levels to matched normal kidney. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
144 Samples
Download data: CEL
Series
Accession:
GSE53757
ID:
200053757
12.

Gene expression in male and female smokers

(Submitter supplied) Smoking is the second leading cause of preventable death in the United States. Cohort epidemiological studies have demonstrated that women are more vulnerable to cigarette-smoking induced diseases than their male counterparts, however, the molecular basis of these differences has been remained unknown to date. In this study, we explored if there were differences in the gene expression patterns between male and female smokers, and how these patterns might reflect different gender-specific responses to the stress of smoking.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
48 Samples
Download data: TXT
Series
Accession:
GSE47415
ID:
200047415
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