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Links from GEO DataSets

Items: 17

1.

Atrial Identity Is Determined by A COUP-TFII Regulatory Network (ChIP-Seq)

(Submitter supplied) Embryonic cardiomyocytes possess the plasticity to choose between atrial and ventricular fates. For a limited window of time, the transcription factor COUP-TFII (Nr2f2) sufficiently and essentially confers the atrial identity through direct and indirect regulation of nearly half of chamber specific genes.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL15103
2 Samples
Download data: WIG
Series
Accession:
GSE46497
ID:
200046497
2.

Atrial Identity Is Determined by A COUP-TFII Regulatory Network

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL15103 GPL1261
11 Samples
Download data: CEL, WIG
Series
Accession:
GSE46498
ID:
200046498
3.

Atrial Identity Is Determined by A COUP-TFII Regulatory Network (RNA)

(Submitter supplied) Atria and ventricles exhibit distinct molecular profiles that produce structural and functional differences between the two cardiac compartments. However, factors that determine these differences remain largely undefined. Cardiomyocyte-specific COUP- TFII ablation produces ventricularized atria that exhibit ventricle-like action potentials, increased cardiomyocyte size, and development of extensive T-tubules. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
9 Samples
Download data: CEL
Series
Accession:
GSE46496
ID:
200046496
4.

Expression data from control and COUP-TFII siRNA treated HUVEC cells

(Submitter supplied) COUP-TFII plays a critical role in angiogenesis during development. It has also been shown to suppress Notch signaling pathway to confer vein identity. However, the downstream targets and the mechanism mediate COUP-TFII function to regulate these processes remain elusive. To identify the downstream targets and the mechanism by which COUP-TFII regulates agiogenesis and vein specification, we knocked down COUP-TFII in HUVEC cells using COUP-TFII specific siRNA and used microarray analysis to identify downstream targets. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL, TXT
Series
Accession:
GSE33301
ID:
200033301
5.

Expression analysis of draculin (drl) expressing cells in embryonic zebrafish

(Submitter supplied) drl expression initiates during gastrulation and condenses as a band of cells at the prospective lateral embryo margin. In late epiboly, drl:EGFP is detectable as a band of scattered EGFP-fluorescent cells; after gastrulation, drl:EGFP-positive cells coalesce at the embryo margin that then in somitogenesis break down into the anterior and posterior lateral plate with subsequent cell migrations that form the posterior vascular/hematopoietic stripes and the anterior cardiovascular and myeloid precursors. more...
Organism:
Danio rerio
Type:
Expression profiling by array
Platform:
GPL16933
6 Samples
Download data: CEL, XLSX
Series
Accession:
GSE70881
ID:
200070881
6.

Gene expression in zebrafish following knockdown of pitx2 or tbx5

(Submitter supplied) Key regulators of septum formation between the left and right ventricle in mammals, including the transcription factors TXB5 and PITX2, feature loss-of-function phenotypes that affect development of the two-chambered zebrafish heart, suggesting uncharacterized primordial functions of these septation regulators prior to the evolution of any physical boundaries between heart chambers. Data is as published in Mosimann & Panakova et al (Nature Communications, 2015)
Organism:
Danio rerio
Type:
Expression profiling by array
Platform:
GPL16933
9 Samples
Download data: CEL
Series
Accession:
GSE70750
ID:
200070750
7.

Gene expression profiles of lymphatic endothelial cells after knockdown of Prox1 and/or NR2F2

(Submitter supplied) Gene expression profiles of primary lymphatic endothelial cells (LECs) isolated from human foreskin were analyzed after siRNA-mediated knockdown of control (firefly luciferase), Prox1, NR2F2 or Prox1/NR2F2 for 48 hours.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3534
Platform:
GPL570
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE12846
ID:
200012846
8.
Full record GDS3534

Lymphatic endothelial cell response to Prox1 and NR2F2 depletion

Analysis of lymphatic endothelial cells (LECs) depleted for Prox1, NR2F2, or both regulators. LECs are derived from venous endothelial cells (VECs). Prox1 and NR2F2 regulate LEC and VEC development, respectively. Results provide insight into the role of NR2F2 and Prox1 in maintaining LEC phenotypes.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 protocol sets
Platform:
GPL570
Series:
GSE12846
4 Samples
Download data: CEL, CHP
9.

Antibody-based selective isolation of atrial and ventricular cardiomyocytes by differential expression of integrin α6 (CD49f)

(Submitter supplied) Central questions like cardiomyocyte subtype emergence during cardiogenesis or availability of cardiomyocyte subtypes for cell replacement therapy require selective identification and purification of atrial and ventricular cardiomyocytes. However, characterization and implementation of pure cardiomyocyte subtypes is still challenging due to technical limitations. Our aim was to identify surface markers enabling the selective detection and purification of atrial and ventricular cardiomyocytes from mouse hearts. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
16 Samples
Download data: TXT
Series
Accession:
GSE57131
ID:
200057131
10.

UTSW Mouse 13.8k cDNA

(Submitter supplied) Spotted mouse cDNA array containing 13872 spots. Clones originate from a combination of in house and commercial (IMAGE) mouse EST libraries. Details of library construction and all target clones can be found at http://pga.swmed.edu.
Organism:
Mus musculus
1 DataSet
1 Series
6 Samples
Download data
Platform
Accession:
GPL1345
ID:
100001345
11.

Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 significantly enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming

(Submitter supplied) Transient over-expression of defined combinations of master regulator genes can effectively induce cellular reprogramming: the acquisition of an alternative predicted phenotype from a differentiated cell lineage. This can be of particular importance in cardiac regenerative medicine wherein the heart lacks the capacity to heal itself, but simultaneously contains a large pool of fibroblasts. In this study we determined the cardio-inducing capacity of ten transcription factors to actuate cellular reprogramming of mouse embryonic fibroblasts into cardiomyocyte-like cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4805
Platform:
GPL8321
12 Samples
Download data: CEL
Series
Accession:
GSE44401
ID:
200044401
12.
Full record GDS4805

Embryonic fibroblast response to overexpression of combinatorial transcription factor modules

Analysis of embryonic fibroblasts (MEFs) transduced with various combinations of transcription factors (TFs) shown to play a role in developmental cardiogenesis. Results provide insight into cardio-inducing capacity of the TFs to actuate cellular reprogramming of MEFs into cardiomyocyte-like cells.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 protocol sets
Platform:
GPL8321
Series:
GSE44401
12 Samples
Download data: CEL
13.

Microarray analysis of normal and abnormal chick myocardial development

(Submitter supplied) The goal of this study was to determine developmental differences in gene expression between left and right ventricle, and to assess the differential effect of altered hemodynamic loading on left and right ventricle. Chick ventricles from different developmental stages were isolated for assessment of normal developmental profiles. Conotruncal banding or partial ligation of the left atrial appendage was performed in ovo at embryonic day 4 and ventricles were isolated at embryonic day 5 (banding) or 8 (ligation) for assessment of altered loading effects.
Organism:
Gallus gallus
Type:
Expression profiling by array
Platform:
GPL3213
24 Samples
Download data: CEL
Series
Accession:
GSE37070
ID:
200037070
14.

Genome-wide Profiling of NR2F2 (COUP-TFII) Binding in Human Endometrial Stromal Cells [ChIP-Seq]

(Submitter supplied) Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII; NR2F2) is an orphan nuclear receptor involved in cell-fate specification, organogenesis, angiogenesis and metabolism. Ablation of COUP-TFII in the mouse uterus causes infertility due to defects in embryo attachment and impaired uterine stromal cell decidualization. Although the function of COUP-TFII in uterine decidualization has been described in mice, its role in the human uterus remains unknown. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9115
2 Samples
Download data: WIG
Series
Accession:
GSE52008
ID:
200052008
15.

COUP-TFII regulates human endometrial stromal genes involved in inflammation

(Submitter supplied) Although the function of COUP-TFII in uterine decidualization has been described in mice, its role in the human uterus remains unknown.To interrogate the role of COUP-TFII in human endometrial function, we utilized a siRNA-mediated loss of function approach in primary human endometrial stromal cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE47052
ID:
200047052
16.

Genome-wide profiling of gene expression of normal and Tbx20 knockout adult mouse whole heart

(Submitter supplied) Tbx20 is a transcription factor important for heart development. To assess the role of Tbx20 in the adult heart, we generated a conditional knockout for this gene, specifically in cardiomyocytes. We profiled gene expression levels using RNA-seq in both normal and knockout adult mouse hearts to identify genes and pathways regulated by Tbx20. The article describing the Tbx20 knockout mouse is under review, a reference will be added when published.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL9185
10 Samples
Download data: BED, TXT
Series
Accession:
GSE30943
ID:
200030943
17.

Sex-dependent gene regulatory networks of the heart rhythm

(Submitter supplied) Expression level, control and intercoordination of 66 selected heart rhythm determinant (HRD) genes were compared in atria and ventricles of 4 male and 4 female adult mice. We found that genes encoding various adrenergic receptors, ankyrins, ion channels and transporters, connexins and other components of the intercalated discs form a complex network that is chamber dependent and differs between the two sexes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8928
16 Samples
Download data: GPR
Series
Accession:
GSE17324
ID:
200017324
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