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Links from GEO DataSets

Items: 6

1.

Holo-TFIID controls the magnitude of a transcription burst and fine-tuning of transcription.

(Submitter supplied) TFIID is a central player in activated transcription initiation. Recent evidence suggests that the role and composition of TFIID is more diverse than previously understood. To investigate the effects of changing the composition of TFIID in a simple system we depleted TAF1 from Drosophila cells and determined the consequences on metal induced transcription at an inducible gene, Metallothionein B (MtnB). more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13304
4 Samples
Download data: TXT
Series
Accession:
GSE45873
ID:
200045873
2.

Genome-wide relationships between TAF1 and histone acetyltransferases in S. cerevisiae - chIP-chip study

(Submitter supplied) Evidence suggests that the TAF1 subunit of TFIID is a histone acetyltransferase (HAT) that is functionally redundant with the Gcn5 HAT of the SAGA and ADA complexes. Here we test a number of predictions of this hypothesis by examining the in vivo histone acetylation targets of TAF1 and Gcn5, and re-examining the basis for the reported genome-wide functional redundancy between TAF1 and Gcn5. Our findings do not support a number of basic tenets of the hypothesis, thus bringing into question the physiological presence of any TAF1 HAT function in yeast. more...
Organism:
Saccharomyces cerevisiae
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL1924
8 Samples
Download data
Series
Accession:
GSE3346
ID:
200003346
3.

Genome-wide relationships between TAF1 and histone acetyltransferases in S. cerevisiae

(Submitter supplied) Evidence suggests that the TAF1 subunit of TFIID is a histone acetyltransferase (HAT) that is functionally redundant with the Gcn5 HAT of the SAGA and ADA complexes. Here we test a number of predictions of this hypothesis by examining the in vivo histone acetylation targets of TAF1 and Gcn5, and re-examining the basis for the reported genome-wide functional redundancy between TAF1 and Gcn5. Our findings do not support a number of basic tenets of the hypothesis, thus bringing into question the physiological presence of any TAF1 HAT function in yeast. more...
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array
Platform:
GPL1220
38 Samples
Download data
Series
Accession:
GSE3345
ID:
200003345
4.

Genome-wide transcriptional dependencies on TAF1 functional domains

(Submitter supplied) TFIID plays a central role in regulating the expression of most eukaryotic genes. Of the 14 TAF subunits that compose TFIID, TAF1 is one of the largest and most functionally diverse. Yeast (Saccharomyces cerevisiae) TAF1 reportedly possesses at least four distinct activities including a histone acetyltransferase, and TBP, TAF, and promoter binding. Establishing the importance of each region in gene expression through deletion analysis has been hampered by the cellular requirement of TAF1 for viability. more...
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array
Platform:
GPL1220
14 Samples
Download data
Series
Accession:
GSE3006
ID:
200003006
5.

A TAF4 coactivator function for E proteins that involves enhanced TFIID binding

(Submitter supplied) The multisubunit TFIID plays a direct role in transcription initiation by binding to core promoter elements and directing preinitiation complex assembly. Although TFIID may also function as a coactivator through direct interactions with promoter-bound activators, mechanistic aspects of this poorly defined function remain unclear. Here biochemical studies show a direct TFIID-E protein interaction that (i) is mediated through interaction of a novel E protein activation domain (AD3) with the TAF homology (TAFH) domain of TAF4, (ii) is critical for activation of a natural target gene by an E protein and (iii) mechanistically, acts by enhancing TFIID binding to the core promoter. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
8 Samples
Download data: BIGWIG, TXT
Series
Accession:
GSE46807
ID:
200046807
6.

Genome-wide Expression Profiling in Peripheral Models of XDP

(Submitter supplied) We performed genome-wide expression profiling using an Agilent microarray in blood- and fibroblast-derived samples from XDP patients and ethnicity-matched Filipino controls. The hypothesis was that TAF1 is dysregulated in peripheral models of XDP and this dysregulation has a concomitant downstream effect on expression genome-wide.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
47 Samples
Download data: TXT
Series
Accession:
GSE74068
ID:
200074068
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Supplemental Content

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