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Links from GEO DataSets

Items: 10

1.

Genome variation profiling of Glioma Stem Cell lines

(Submitter supplied) Glioblastoma multiforme (GBM), the most common and malignant type of glioma, is characterized by a poor prognosis and the lack of an effective treatment, which are due to a small sub-population of cells with stem-like properties, termed glioma stem cells (GSCs). The term “multiforme” describes the histological feature of this tumor, i.e. the cellular and morphological heterogeneity. At the molecular level multiple layers of alterations may reflect this heterogeneity providing together the driving force of tumor initiation and development. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL8841
5 Samples
Download data: TXT
Series
Accession:
GSE41875
ID:
200041875
2.

Methylation profiling of Glioma Stem Cell lines vs GBM FFPE tissue biopsies and foetal Neural Stem Cell lines

(Submitter supplied) The DNA methylation profiles of Glioma Stem Cell (GSC) lines were investigated in order to find the stem cell signature associated to glioblastoma (GBM). This goal was achieved through the comparison of GSC methylation data with FFPE-GBM biopsies and human foetal Neural Stem Cell (NSC) lines profiles.
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL9767
6 Samples
Download data: TXT
Series
Accession:
GSE41824
ID:
200041824
3.

Dendritic Cell Vaccine against Glioblastoma Multiforme Patients

(Submitter supplied) Human Glioblastoma Multiforme tumors taken before dendritic cell vaccination, the recurrent tumors taken after vaccination and control GBM tumors from non vaccinated patients. Keywords: Disease State Analysis
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
22 Samples
Download data: CEL
Series
Accession:
GSE11100
ID:
200011100
4.

Cooperative actions of p53 and Pten in normal and neoplastic progenitor cell renewal and differentiation

(Submitter supplied) Glioblastoma (GBM) is a highly lethal brain tumor presenting as one of two subtypes with distinct clinical histories and molecular profiles. The primary GBM subtype presents acutely as high-grade disease that typically harbors EGFR, PTEN and Ink4a/Arf mutations, and the secondary GBM subtype evolves from the slow progression of low-grade disease that classically possesses PDGF and p53 events1. Here, we show that concomitant CNS-specific deletion of p53 and Pten in the mouse CNS generates a penetrant acute-onset high-grade malignant glioma phenotype with striking clinical, pathological and molecular resemblance to primary GBM in humans. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
5 Samples
Download data: CEL
Series
Accession:
GSE12694
ID:
200012694
5.

Expression data for minimally invasive glioblastoma stem-like cell (GSC) plasma membrane markers

(Submitter supplied) We compared whole genome expression profiles of GSCs with normal human cortex, human neural stem cells (hNSC) from fetal cortex, glioblastoma (GBM) primary, and recurrent tumors to find GSC-specific plasma membrane transcripts.
Organism:
Homo sapiens
Type:
Expression profiling by array; Third-party reanalysis
Platform:
GPL570
2 Samples
Download data: CEL, TXT, XLS
Series
Accession:
GSE51822
ID:
200051822
6.

Identification and molecular characterization of distinct glioblastoma cancer stem cell populations

(Submitter supplied) Malignant glioblastoma (GBM) is a highly aggressive brain tumor with a dismal prognosis and limited therapeutic options. Genomic profiling of GBM samples in the TCGA database has identified four molecular subtypes (Proneural, Neural, Classical and Mesenchymal), which may arise from different glioblastoma stem-like cell (GSC) populations. In the present study, we identify two GSC populations that produce GBM tumors by subcutaneous and intracranial injection with identical histological features. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
12 Samples
Download data: IDAT
Series
Accession:
GSE65576
ID:
200065576
7.

Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas.

(Submitter supplied) Background: Gliomas are the most common type of primary brain tumours, and in this group glioblastomas (GBMs) are the higher-grade gliomas with fast progression and unfortunate prognosis. Two major aspects of glioma biology that contributes to its awful prognosis are the formation of new blood vessels through the process of angiogenesis and the invasion of glioma cells. Despite of advances, two-year survival for GBM patients with optimal therapy is less than 30%. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
16 Samples
Download data: CEL, CHP, TXT
Series
Accession:
GSE18015
ID:
200018015
8.

Development of gene expression signatures for miR-218 overexpression

(Submitter supplied) To investigate differences in gene expression after overexpression miR-218 in U251MG
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14550
2 Samples
Download data: TXT
Series
Accession:
GSE46059
ID:
200046059
9.

Comparison study of glioma stem cells and adult human neural stem cells

(Submitter supplied) Glioblastoma, the most common and malignant brain tumor, harbors stem-like cells that self-renew and propagate upon serial transplantation. Although they share functional, morphological and developmental similarities to adult brain neural stem cells, stem cell characteristic pathways contributing to glioblastoma stem-like cells have not been consistently determined. Towards this goal we have provided an internally coherent molecular reference that compares adult neural and glioblastoma stem cells cultivated under identical conditions. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2986
14 Samples
Download data: TXT
Series
Accession:
GSE31262
ID:
200031262
10.

Ion Channel Expression Patterns in Glioblastoma Stem Cells with Functional and Therapeutic Implications for Malignancy

(Submitter supplied) Ion channels and transporters have increasingly recognized roles in cancer progression through the regulation of cell proliferation, migration, and death. Glioblastoma stem-like cells (GSCs) are a source of tumor formation and recurrence in glioblastoma multiforme, a highly aggressive brain cancer, suggesting that ion channel expression may be perturbed in this population. However, little is known about the expression and functional relevance of ion channels that may contribute to GSC malignancy. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
69 Samples
Download data: TXT
Series
Accession:
GSE89623
ID:
200089623
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