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Links from GEO DataSets

Items: 20

1.

MicroRNA expression profiling of small-intestine neuroendocrine tumors and human neuroendocrine tumor cell lines

(Submitter supplied) Small intestinal neuroendocrine tumors (SI-NETs) arise from serotonin-producing enterochromaffin cells. SI-NETs are often well-differentiated tumors and most patients have regional or distant metastases at initial presentation. MicroRNAs (miRs) are post-transcriptional regulators which are important in diverse biological processes and can function as tumor suppressor genes or oncogenes. This study aims to identify an exclusive SI-NETs miR profile that may have a critical role in development, diagnosis, prognosis and progression of these malignancies.
Organism:
Homo sapiens; synthetic construct
Type:
Non-coding RNA profiling by array
Platform:
GPL8786
25 Samples
Download data: CEL, TXT
Series
Accession:
GSE33568
ID:
200033568
2.

Gene expression profiling of classical midgut carcinoid primary tumors and liver metastasis

(Submitter supplied) We identify genes presenting a specific expression profile in midgut carcinoid cells, primary carcinoids tumors and liver metastasis were gene profiled. Gene expression profiling of classical midgut carcinoid primary tumors and liver metastasis reveal potential novel therapeutic targets and molecular signatures. Keywords: disease state comparison
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE9576
ID:
200009576
3.

Development of microRNA expression signatures in laryngeal tumors

(Submitter supplied) Background: MicroRNA (miRNA) is an emerging subclass of small non-coding RNAs that regulates gene expression and has a pivotal role for many physiological processes including cancer development. Recent reports revealed the role of miRNAs as ideal biomarkers and therapeutic targets due to their tissue- or disease-specific nature. Head and neck cancer (HNC) is a major cause of cancer-related mortality and morbidity, and laryngeal cancer has the highest incidence in it. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL8227
5 Samples
Download data: TXT
Series
Accession:
GSE47610
ID:
200047610
4.

MicroRNA signature of thyroid tumors of uncertain malignancy

(Submitter supplied) Well-differentiated tumours (WDT) of the thyroid gland can be difficult to diagnose. Focal nuclear clearing can be suggestive of a papillary thyroid carcinoma (PTC), while questionable vascular or capsular penetration may raise the possibility of diagnosis of a follicular thyroid carcinoma (FTC). The recently proposed term “thyroid tumours of uncertain malignant potential” (TT-UMP) defines cases showing inconclusive morphological evidence of malignancy. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL4717
89 Samples
Download data: GPR
Series
Accession:
GSE15740
ID:
200015740
5.

Comparative microarray analysis of microRNA expression profiles in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases and benign melanocytic naevi

(Submitter supplied) Perturbations in microRNA (miRNA) expression profiles has been reported for cutaneous malignant melanoma (CMM). With regards to a rapidly growing number of newly discovered miRNA sequences, the availability of up-to-date miRNA expression profiles for primary cutaneous malignant melanoma (PCMM), cutaneous malignant melanoma metastases (CMMM) and benign melanocytic naevi (BMN) is limited. Patients with PCMM (n=9), CMMM (n=4) and BMN (n=8) were included in the study. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL15019
21 Samples
Download data: TXT
Series
Accession:
GSE34460
ID:
200034460
6.

microRNAs and their target proteins are associated with characteristics of estrogen receptor-positive breast cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array; Expression profiling by array
Platforms:
GPL5639 GPL13746
16 Samples
Download data: GPR
Series
Accession:
GSE38280
ID:
200038280
7.

microRNAs and their target proteins associated with characteristics of estrogen receptor-positive breast cancer (mRNA data)

(Submitter supplied) Recent analyses have identified heterogeneity in estrogen receptor (ER)-positive breast cancer. There are so-called luminal A and luminal B subtypes, and the characteristics, such as response to endocrine therapy and chemotherapy and prognosis, are different in these two subtypes of breast cancer. In this study, expression profiles of microRNAs (miRNAs) and mRNAs in ER-positive breast cancer tissues were compared between highly and incompletely endocrine responsive tumors by miRNA and mRNA microarrays. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5639
8 Samples
Download data: GPR
Series
Accession:
GSE38279
ID:
200038279
8.

microRNAs and their target proteins are associated with characteristics of estrogen receptor-positive breast cancer (miRNA data)

(Submitter supplied) Recent analyses have identified heterogeneity in estrogen receptor (ER)-positive breast cancer. There are so-called luminal A and luminal B subtypes, and the characteristics, such as response to endocrine therapy and chemotherapy and prognosis, are different in these two subtypes of breast cancer. In this study, expression profiles of microRNAs (miRNAs) and mRNAs in ER-positive breast cancer tissues were compared between highly and incompletely endocrine responsive tumors by miRNA and mRNA microarrays. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL13746
8 Samples
Download data: GPR
Series
Accession:
GSE38278
ID:
200038278
9.

Tissue and blood microRNA array profiles of colorectal cancer patients

(Submitter supplied) microRNAs (miRNAs) are short, non-coding RNA molecules that act as regulators of gene expression. Circulating blood miRNAs offer great potential as cancer biomarkers. The objective of the study was to correlate the differential expression of miRNAs in tissue and blood in the identification of biomarkers for early detection of colorectal cancer (CRC).
Organism:
synthetic construct; Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL14613
26 Samples
Download data: CEL
Series
Accession:
GSE39845
ID:
200039845
10.

High-throughput microRNA (miRNAs) arrays in pancreatic cancer

(Submitter supplied) Background: Only a subset of radically-resected pancreatic ductal adenocarcinoma (PDAC) patients benefit from chemotherapy, and identification of novel prognostic factors is warranted. Recently miRNAs emerged as diagnostic biomarkers and innovative therapeutic targets, while high-throughput arrays are opening new opportunities to evaluate whether they can also predict clinical outcome. The present study evaluated whether comprehensive miRNA expression profiling correlated with overall survival (OS) in resected PDAC patients. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL14903
19 Samples
Download data: TXT
Series
Accession:
GSE38781
ID:
200038781
11.

Expression data from human embryonic (9-12w) and post-natal livers

(Submitter supplied) The liver is a multifunctional organ, which undergoes rapid changes during the developmental period and relies on tightly-regulated gene expression. Little is known regarding the complex expression patterns of mRNAs during the early stages of human liver development in comparison to post-natal livers. We used microarrays to detail the global programme of gene expression during liver development following specification, at the stage of proliferation and differentiation when compared to post-natal livers, and identified distinct classes of up-regulated and downregulated genes during this process.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
13 Samples
Download data: CEL
Series
Accession:
GSE15238
ID:
200015238
12.

miR-18a regulates the miRNAs by target Dicer in Nasopharyngeal carcinoma HK-1 cell.

(Submitter supplied) As the biogenesis of miRNAs depends on the cleavage by the RNase III enzyme Dicer, miR-18a may change the miRNA expression profiles by targeting dicer. We then performed the miRNA array assay to investigate the miRNA profiles change caused by miR-18a.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL8179
3 Samples
Download data: TXT
Series
Accession:
GSE32680
ID:
200032680
13.

Characterization of B- and T-lineage ALL by Integrated Analysis of microRNA and mRNA Expression Profiles

(Submitter supplied) Acute lymphoblastic leukemia (ALL) is an heterogeneous disease comprising several subentities that differ for both immunophenotypic and molecular characteristics. Over the years, the biologic understanding of this neoplasm has largely increased. Gene expression profiling has recently allowed to identify specific signatures for the different ALL subsets and permitted identification of pathways deregulated by a given lesion. more...
Organism:
Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL570 GPL8191
39 Samples
Download data: CEL, XLS
Series
Accession:
GSE14834
ID:
200014834
14.

MicroRNA expression profiling on formalin-fixed paraffin-embedded (FFPE) tissue blocks of human adrenal pheochromocytomas

(Submitter supplied) MicroRNAs are involved in the pathogenesis of several tumors, however, there have been no data on microRNA expression in pheochromocytomas to date. In this study we have performed microRNA expression profiling in sporadic benign, hereditary benign (multiplex endocrine neoplasia type 2-related and von Hippel-Lindau syndrome-related pheochromocytomas), and sporadic recurring adrenomedullary tumors. Due to the rarity of these neoplasms, the retrieval of sufficient quantities of fresh or immediately snap frozen tumor samples is difficult, therefore the applicability of formalin-fixed paraffin-embedded tissue samples for the analysis of microRNA expression in pheochromocytomas was examined.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL10406
24 Samples
Download data: TXT
Series
Accession:
GSE21767
ID:
200021767
15.

Reference Genes for MiRNAome Analysis of Urothelial Carcinomas

(Submitter supplied) Background/Objective: Quantitative real-time PCR (RT-qPCR) is widely used in miRNA expression studies on cancer. To compensate for the analytical variability produced by the multiple steps of the method, relative quantification of the measured miRNAs is required, which is based on normalization to endogenous reference genes. A literature search in PubMed revealed that no study has been performed so far on reference miRNAs for normalization of miRNA expression in urothelial carcinoma. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL8227
24 Samples
Download data: TXT
Series
Accession:
GSE36121
ID:
200036121
16.

Gene expression signatures in a human bladder cancer cell line SW780 transfected with miR-137 precursor molecule

(Submitter supplied) To clarify the effect of miRNAs, we carried out a gene expression microarray analysis of SW780 cells transfected with a miR-137 precursor or a negative control. We found that 1,326 probe sets (1,016 unique genes) were downregulated (>2-fold) by ectopic miR-137 expression, including the previously reported miR-137 target genes CDK6, CDC42 and AURKA. Moreover, Gene Ontology analysis revealed that genes related to the cell cycle were significantly enriched among the affected genes.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13607
2 Samples
Download data: TXT
Series
Accession:
GSE41760
ID:
200041760
17.

Altered miRNA and gene expression in acute myeloid leukemia with complex karyotype identify networks of prognostic relevance

(Submitter supplied) Recently, the p53-miR-34a network was identified to play an important role in tumorigenesis. As in acute myeloid leukemia with complex karyotype (CK-AML) TP53 alterations are the most common known molecular lesion, we further analyzed the p53-miR-34a axis in CK-AML with known TP53 status. Clinically, low miR-34a expression and TP53 alterations predicted for chemotherapy resistance and inferior outcome. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
12 Samples
Download data: CEL
Series
Accession:
GSE39730
ID:
200039730
18.

Global miRNA expression in small bowel neuroendocrine tumors (SBNET) and their lymph node/liver metastases

(Submitter supplied) miRNA profiling study revealing novel miRNAs deregulated in SBNET compared to normal small bowel and identifying miRNA that are differentially regulated with disease progression. These have the potential to be used in the future for patient stratification and treatment response monitoring.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL17537
90 Samples
Download data: RCC
Series
Accession:
GSE70534
ID:
200070534
19.

Integrated DNA methylation and RNA expression in Small Intestinal neuroendocrine tumors

(Submitter supplied) Background and Aims Small intestinal neuroendocrine tumours (SINETs) are the commonest malignancy of the small intestine; however underlying pathogenic mechanisms remain poorly characterised. Whole genome and exome sequencing has demonstrated that SINETs are mutationally quiet with the most frequent known mutation in the cyclin dependent kinase inhibitor 1B gene (CDKN1B) occurring in only ~8% of tumours, suggesting that alternative mechanisms may drive tumourigenesis. more...
Organism:
Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL13534
133 Samples
Download data: TXT
Series
Accession:
GSE73832
ID:
200073832
20.

Laser capture microdissection followed by next-generation sequencing identifies disease-related microRNAs in psoriatic skin that mirror the systemic psoriatic miRNome

(Submitter supplied) Psoriasis is a systemic disease with cutaneous manifestations. MicroRNAs (miRNAs) are non-coding RNA molecules that are differentially expressed in psoriatic skin, however; only few miRNAs have been localized to specific cells or regions of psoriatic lesions. We used laser capture microdissection (LCM) and next-generation sequencing to study the specific miRNA expression profiles in the epidermis (Epi) and dermal inflammatory aggregates (RD/ICs) of psoriatic skin. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL16791
36 Samples
Download data: TXT
Series
Accession:
GSE57012
ID:
200057012
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