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Links from GEO DataSets

Items: 20

1.

Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors

(Submitter supplied) Thymic epithelial tumors are a group of neoplasms with heterogeneous histological features and clinical behavior. The identification of markers useful to predict patient prognosis and molecular targets for therapies is limited by a very little understanding of the biology of these neoplasms. We evaluated the copy number (CN) aberrations of genes involved in normal thymus development in thymic epithelial tumors, following the intriguing idea that the ectopic deregulation of genes relevant for proliferation and differentiation of embryonic cells, can contribute to tumor growth. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platforms:
GPL4093 GPL10123
62 Samples
Download data: TXT
Series
Accession:
GSE23540
ID:
200023540
2.

HER2-positive breast cancer cells resistant to trastuzumab and lapatinib lose reliance upon HER2 and are sensitive to the multitargeted kinase inhibitor sorafenib

(Submitter supplied) HER2 targeting with trastuzumab has changed the prognosis of breast cancer patients carrying amplification and/or overexpression of this oncogene. Despite this progress, however, resistance to trastuzumab occurs in the vast majority of patients. Newer anti-HER2 therapies, like the dual tyrosine-kinase inhibitor (TKI) lapatinib, show antitumor activity in a limited proportion of patients, indicating that HER2 can be still exploited as a target after trastuzumab failure. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
2 Samples
Download data: TXT
Series
Accession:
GSE17630
ID:
200017630
3.

Mcl-1 is a key determinant of breast cancer cell survival

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; Expression profiling by array
Platforms:
GPL571 GPL6801
95 Samples
Download data: CEL
Series
Accession:
GSE66072
ID:
200066072
4.

Mcl-1 is a key determinant of breast cancer cell survival [expression]

(Submitter supplied) mRNA expression profile of cultured Breast Cancer cell line measured by Affymetrix microarrays
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
93 Samples
Download data: CEL
Series
Accession:
GSE66071
ID:
200066071
5.

Mcl-1 is a key determinant of breast cancer cell survival [copy number]

(Submitter supplied) Copy number profile of cultured Breast Cancer cell line measured by Affymetrix SNPs microarrays
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platform:
GPL6801
2 Samples
Download data: CEL
Series
Accession:
GSE66070
ID:
200066070
6.

Gene expression data from human metastatic melanoma tumors that may predict response to RAF265

(Submitter supplied) To determine how mutation of BRAF affected the response to RAF265, we utilized a tumor orthotopic implant model of early passage melanoma tumors in nude mice from a series of 17 patients with advanced metastatic Tumor growth was compared between RAF265 treatment (40 mg/kg, QD) and diluent control groups. The melanoma associated gene mutation profile and global gene expression profile were determined on these human melanoma samples by SNaPshot and Affymetrix Human Gene ST 1.0 Array, respectively. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
42 Samples
Download data: CEL
Series
Accession:
GSE30812
ID:
200030812
7.

Follicular Lymphoma Array CGH

(Submitter supplied) We run aCGH of 64 FL samples and we looked for recurrent chromosomal alterations.
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL9128
64 Samples
Download data
Series
Accession:
GSE40989
ID:
200040989
8.

Follicular Lymphoma expression array

(Submitter supplied) We used microarrays to detail gene expression profile of several follicular lymphoma patient samples with different grades
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
72 Samples
Download data: CEL
Series
Accession:
GSE37088
ID:
200037088
9.

Array-Comparative Genomic Hybridization Reveals Loss of SOCS6 is Associated with Poor Prognosis in Primary Lung Squamous Cell Carcinoma

(Submitter supplied) Primary tumor recurrence occurs commonly after surgical resection of lung squamous cell carcinoma (SCC). The aim of this study was to identify genes involved in recurrence in lung squamous cell carcinoma patients. Array comparative genomic hybridization (aCGH) was performed on DNA extracted from tumour tissue from 62 patients with primary lung squamous cell carcinomas. aCGH data was analysed to identify genes affected by copy number alterations that may be involved in SCC recurrence. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL2879
62 Samples
Download data: TXT
Series
Accession:
GSE32058
ID:
200032058
10.

Carboxypeptidase of glutamate-like gene as a tumor suppressor in pancreatic cancer cells and a prognostic marker for resected pancreatic cancer patients

(Submitter supplied) Pancreatic cancer is the fourth leading cancer-related death in United States. The clinical relevance of genomic imbalances in pancreatic cancer is uncertain. We performed array-comparative genomic hybridization (aCGH) in 44 resected pancreatic cancer specimens from a Korean cohort. We observed recurrent copy number gains were observed in chromosome 1q, 11q, 18q11.1-11.2, and 20q13.13; and losses in chromosome 2p, 9p, 10q, 14q, 15q, 18q12.2-23, 19q, 20q11.1, 21p, and 22q. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL4093
44 Samples
Download data: TXT
Series
Accession:
GSE28732
ID:
200028732
11.

Human esophageal dysplasia (16 cases) vs. esophageal squamous cell carcinoma (59 cases)

(Submitter supplied) Our aim is to identify frequent genomic aberrations both in ESCC and esophageal dysplasia, and to discover important copy number-driving genes and microRNAs in ESCC. We carried out array-based comparative genomic hybridization (array CGH) on 59 ESCC resection samples and 16 dysplasia biopsy samples. Expression of genes at 11q13.3 was analyzed by real-time PCR and immunohistochemistry (IHC). Integrated analysis was performed to identify genes or microRNAs with copy number-expression correlations.
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platforms:
GPL17052 GPL8841
75 Samples
Download data: TXT
Series
Accession:
GSE46452
ID:
200046452
12.

A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors

(Submitter supplied) Next generation sequencing of 28 thymic epithelial tumors (TETs) revealed a high frequency of GTF2I missense mutation (chr7:74146970T/A) in A thymomas, a relatively indolent subtype. The GTF2I mutation was confirmed in 82% of A and 74% of AB thymomas in a series of 274 TETs but was rare in aggressive subtypes, where recurrent mutations of known cancer genes were identified. Therefore, GTF2I mutation correlated with a better survival. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL9115 GPL11154
25 Samples
Download data: TXT
Series
Accession:
GSE57892
ID:
200057892
13.

GTF2I Mutations are Common in Thymic Epithelial Tumors

(Submitter supplied) Within a project aim to define the genomic aberration of thymic epithelial tumors, we performed array CGH in 65 thymic epithelial tumors. Tumor samples were collected during surgery or by image-guided biopsies and immediately frozen. Section from frozen material were cut and stained with Haematoxylin and Eosin. A pathologist reviewed the slides and selected only cases with >80% of cancer cells.
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL10123
65 Samples
Download data: TXT
Series
Accession:
GSE55852
ID:
200055852
14.

Affymetrix 250K StyI SNP array data across multiple human cancer types

(Submitter supplied) A powerful way to discover key genes playing causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. We have reported high-resolution analyses of somatic copy-number alterations (SCNAs) from 3131 cancer specimens, belonging largely to 26 histological types. We identify 158 regions of focal SCNA that are altered at significant frequency across multiple cancer types, of which 122 cannot be explained by the presence of a known cancer target gene located within these regions. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platform:
GPL3720
826 Samples
Download data: CEL, TXT
Series
Accession:
GSE19399
ID:
200019399
15.

Gene expression profiles of tumor and paired normal lung tissues from primary non-small cell lung cancer (NSCLC) patients in Taiwan.

(Submitter supplied) Genome-wide expression profiling of NSCLC patients were done using Phalanx Human OneArray chip. The surgically resected tumor tissue and corresponding normal tissue were collected from 21 patients diagnosed with primary NSCLC admitted to Taipei Veterans General Hospital, Taiwan.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6254
42 Samples
Download data: GPR
Series
Accession:
GSE21933
ID:
200021933
16.

Novel Lung Cancer-Related Genes Identified by a Non-Gapped Array-Comparative Genomic Hybridization Microarray in Asian and Caucasian Populations

(Submitter supplied) This study constructed a non-gapped bacterial artificial chromosomes (BAC) array containing 3604 BAC clones covering 18 lung cancer-related chromosome imbalance hotspot regions. Using this specialized array, DNA from tumor and normal tissues of 40 Asian and 20 Caucasian non-small cell lung cancer (NSLCL) patients was analyzed by array-comparative genomic hybridization (array-CGH). Block-wise normalization and a Bayes regression approach were used to refine the chromosomal imbalance regions identified by array-CGH. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL10303
60 Samples
Download data: GPR
Series
Accession:
GSE21276
ID:
200021276
17.

Gene expression profiles of thymic neuroendocrine tumors (carcinoids) with ectopic ACTH syndrome

(Submitter supplied) Although there has been increased knowledge about the molecular biology of neuroendocrine tumors (NETs), little is known about thymic carcinoids and even less about those with excessive hormone disorders, such as ectopic ACTH syndrome. This study was designed to gain insights into molecular networks underlying the tumorigenesis of thymic carcinoids with ACTH secretion. By an approach integrating cDNA microarray and methods of computational biology, we compare gene expression profile between ACTH-producing thymic carcinoids and normal thymus. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8713
11 Samples
Download data: GPR
Series
Accession:
GSE17619
ID:
200017619
18.

Effect of genomic imbalances on gene expression in rhabdomyosarcoma

(Submitter supplied) Rhabdomyosarcoma (RMS) is the most common paediatric soft-tissue sarcoma and resembles developing skeletal muscle. Specific genomic alterations including translocations, deletions and amplification events have been associated with the alveolar and embryonal subtypes of RMS. Characterizing these changes has led to increased understanding of the underlying molecular biology. However, further aberrations and their significance remain to be defined. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
13 Samples
Download data: CEL, CHP
Series
Accession:
GSE8840
ID:
200008840
19.

Micro-scale genomic copy number aberrations as another means of mutagenesis in breast cancer

(Submitter supplied) Introduction: In breast cancers, the basal-like subtype has high levels of genomic instability relative to other breast cancer subtypes with many basal-like-specific regions of aberration. There is evidence that this genomic instability extends to smaller scale genomic aberrations as well, as shown by a previously described micro-event in the PTEN gene in the Basal-like SUM149 breast cancer cell line. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array; Genome variation profiling by genome tiling array
8 related Platforms
192 Samples
Download data
Series
Accession:
GSE36889
ID:
200036889
20.

FOXP1 inhibits cell growth and attenuates tumorigenicity of neuroblastoma

(Submitter supplied) Single-color gene expression profiles from 3 neuroblastoma cell lines were generated using 44K oligonucleotide microarrays. To gain insights into the molecular processes occurring upon FOXP1 re-expression, we performed series of time-resolved gene expression measurements in FOXP1 and GFP transgenic neuroblastoma cell lines.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16876
24 Samples
Download data: TXT
Series
Accession:
GSE62419
ID:
200062419
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