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Links from GEO DataSets

Items: 20

1.

MicroRNAs and gene expression profiles of rapamycin sensitive and resistant myogenic tumor cell line

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL9939 GPL1261
21 Samples
Download data: CEL, CHP, TXT
Series
Accession:
GSE19944
ID:
200019944
2.

MicroRNAs mediate rapamycin resistance in a myogenic tumor cell line

(Submitter supplied) The mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation. Inhibitors of mTOR are being evaluated as anti-tumor agents. Given the emerging role of microRNAs (miRNAs) in tumorgenesis we hypothesized that miRNAs could play important roles in the response of tumors to mTOR inhibitors. Rapamycin resistant myogenic cells developed by long-term rapamycin treatment showed extensive reprogramming of miRNAs expression, characterized by up-regulation of the mir-17~92 and related clusters and down-regulation of tumor-suppressor miRNAs. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL9939
12 Samples
Download data: TXT
Series
Accession:
GSE19916
ID:
200019916
3.

Gene expression data from rapamycin resistant and sensitive cell lines

(Submitter supplied) The mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation. Inhibitors of mTOR are being evaluated as anti-tumor agents. Given the emerging role of microRNAs (miRNAs) in tumorgenesis we hypothesized that miRNAs could play important roles in the response of tumors to mTOR inhibitors. Rapamycin resistant myogenic cells developed by long-term rapamycin treatment showed extensive reprogramming of miRNAs expression, characterized by up-regulation of the mir-17~92 and related clusters and down-regulation of tumor-suppressor miRNAs. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
9 Samples
Download data: CEL, CHP
Series
Accession:
GSE19885
ID:
200019885
4.

Rapamycin treatment of MDA-MB-468 breast cancer cell line and MDA-MB-468 xenografts

(Submitter supplied) Mammalian target of rapamycin (mTOR) is a serine/threonine kinase involved in multiple intracellular signaling pathways promoting tumor growth. mTOR is aberrantly activated in a significant portion of breast cancers and is a promising target for treatment. Rapamycin and its analogues are in clinical trials for breast cancer treatment. Patterns of gene expression (metagenes) may also be used to simulate a biologic process of effects of a drug treatment. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
18 Samples
Download data: CEL
Series
Accession:
GSE18571
ID:
200018571
5.

Transcriptional profiling of ATP-competitive mTOR inhibitors reveals mTORC1 and mTORC2 specific regulatory networks

(Submitter supplied) The mammalian target of rapamycin (mTOR) is a central regulator of cell growth and proliferation in response to growth factor and nutrient signaling. Consequently, this kinase is implicated in metabolic diseases including cancer and diabetes so there is great interest in understanding mTOR regulatory networks. mTOR exists in two functionally distinct complexes, mTORC1 and mTORC2, and whereas the natural product rapamycin only inhibits a subset of mTORC1 functions, recently developed ATP-competitive mTOR inhibitors have revealed new roles for both complexes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
12 Samples
Download data: TXT
Series
Accession:
GSE27784
ID:
200027784
6.

Gene expression analyses of putative miRNA targets in ovarian clear cell cancer cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
40 Samples
Download data: TXT
Series
Accession:
GSE16574
ID:
200016574
7.

Gene expression analyses of mir-182 knockdown in ovarian clear cell cancer cell line

(Submitter supplied) A variety of human cancers demonstrate alterations in microRNA expression. We hypothesized that regulatory defects in microRNAs play a central early role in organizing the molecular changes involved in ovarian cancer (OvCa). Using both gene arrays and deep sequencing, we comprehensively profiled mRNA and microRNA expression, respectively, in human clear cell epithelial OvCa cell lines and short-term primary cultures of normal ovarian surface epithelium. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
6 Samples
Download data: TXT
Series
Accession:
GSE16572
ID:
200016572
8.

Gene expression analyses of mir-100 overexpression in ovarian clear cell cancer cell line

(Submitter supplied) A variety of human cancers demonstrate alterations in microRNA expression. We hypothesized that regulatory defects in microRNAs play a central early role in organizing the molecular changes involved in ovarian cancer (OvCa). Using both gene arrays and deep sequencing, we comprehensively profiled mRNA and microRNA expression, respectively, in human clear cell epithelial OvCa cell lines and short-term primary cultures of normal ovarian surface epithelium. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
6 Samples
Download data: TXT
Series
Accession:
GSE16571
ID:
200016571
9.

Gene expression analyses of ovarian clear cell cancer cell lines

(Submitter supplied) A variety of human cancers demonstrate alterations in microRNA expression. We hypothesized that regulatory defects in microRNAs play a central early role in organizing the molecular changes involved in ovarian cancer (OvCa). Using both gene arrays and deep sequencing, we comprehensively profiled mRNA and microRNA expression, respectively, in human clear cell epithelial OvCa cell lines and short-term primary cultures of normal ovarian surface epithelium. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
16 Samples
Download data: TXT
Series
Accession:
GSE16570
ID:
200016570
10.

Gene expression analyses of mir-30a knockdown in ovarian clear cell cancer cell line

(Submitter supplied) A variety of human cancers demonstrate alterations in microRNA expression. We hypothesized that regulatory defects in microRNAs play a central early role in organizing the molecular changes involved in ovarian cancer (OvCa). Using both gene arrays and deep sequencing, we comprehensively profiled mRNA and microRNA expression, respectively, in human clear cell epithelial OvCa cell lines and short-term primary cultures of normal ovarian surface epithelium. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
6 Samples
Download data: TXT
Series
Accession:
GSE16569
ID:
200016569
11.

Gene expression analyses of mir-22 overexpression in ovarian clear cell cancer cell line

(Submitter supplied) A variety of human cancers demonstrate alterations in microRNA expression. We hypothesized that regulatory defects in microRNAs play a central early role in organizing the molecular changes involved in ovarian cancer (OvCa). Using both gene arrays and deep sequencing, we comprehensively profiled mRNA and microRNA expression, respectively, in human clear cell epithelial OvCa cell lines and short-term primary cultures of normal ovarian surface epithelium. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
6 Samples
Download data: TXT
Series
Accession:
GSE16568
ID:
200016568
12.

Modulation of gene expression by rapamycin in hepatic cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platforms:
GPL6101 GPL1355
24 Samples
Download data: CEL
Series
Accession:
GSE17677
ID:
200017677
13.

Modulation of gene expression by rapamycin in hepatic cell lines, H5D and GN5

(Submitter supplied) Two rat hepatic cell lines, GN5 and H5D, were characterized for the effect of rapamycin on gene expression. These cells lines are tumorigenic and display intermediate sensitivity to the growth inhibitory effects of rapamycin. The goal of this experiment was to assess the effect of rapamycin on gene expression independent of effects on cell proliferation.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
12 Samples
Download data: TXT
Series
Accession:
GSE17662
ID:
200017662
14.

Modulation of gene expression by rapamycin in hepatic cell lines, WB-F344 and WB311

(Submitter supplied) Two rat hepatic cell lines, WB-F344 and WB311, were characterized for the effect of rapamycin on gene expression. The WB311 cell line, which is tumorigenic and resistant to the growth inhibitory effects of rapamycin, was originally derived from the WB-F344 parental hepatic epithelial cell line. The goal of this experiment was to identify genes that responded to rapamycin in the sensitive cells but not the resistant cells, thereby providing insight into the mechanism of rapamycin resistance.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
12 Samples
Download data: CEL
Series
Accession:
GSE17661
ID:
200017661
15.

Regulation of Rat Hepatic Translation by mTOR

(Submitter supplied) Our strategy was to manipulate mTOR signaling in vivo, then characterize the transcriptome and translating mRNA in liver tissue. In adult rats, we used the non-proliferative growth model of refeeding after a period of fasting, and the proliferative model of liver regeneration following partial hepatectomy. We also studied livers from pre-term fetal rats (embryonic day 19-20) in which fetal hepatocytes are asynchronously proliferating. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6247
40 Samples
Download data: CEL
Series
Accession:
GSE67022
ID:
200067022
16.

Estrogen receptors in breast cancer stem cells

(Submitter supplied) Breast cancer stem cells are considered estrogen receptor negative and estrogen insensitive. However, estrogens potentiate growth of the vast majority of breast tumors. In this study, we characterize the expression of estrogen receptors in breast cancer stem cells. We used microarrays to characterize the global gene expression underlying estrogen receptor activation versus inhibition in breast cancer cells from invasive breast cancers.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
24 Samples
Download data: CEL
Series
Accession:
GSE35031
ID:
200035031
17.

Murine Spermatogonial Stem Cells: Rapamycin- vs Vehicle-exposed in vivo (2-wk treatment)

(Submitter supplied) Male FVB strain mice aged 12-days-old through 26-days-old were administered daily intraperitoneal injections of rapamycin (4mg/kg body weight) or control vehicle (5% Tween-80, 5% PEG-400), beginning at postnatal day (P)12. Mice were euthanized at P26 and their testes were isolated for germ cell enrichment. Single cell suspensions of germ cells were prepared from isolated testes and subjected to magnetic-activated cell sorting (MACS). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
1 Sample
Download data: TXT
Series
Accession:
GSE37062
ID:
200037062
18.

Short-term rapamycin treatment in mice have few effects on the transcriptome of white adipose tissue compared to dietary restriction

(Submitter supplied) Analysis of the transcriptome in the epididymal fat of young mice (8 months of age) from treatment of dietary restriction, or rapamycin
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
24 Samples
Download data: TXT
Series
Accession:
GSE52825
ID:
200052825
19.

Expression data from BT-474 cells long-term treated with everolimus

(Submitter supplied) Inhibitors of the mechanistic target of rapamycin (mTOR) are currently used to treat advanced metastatic breast cancer. However, whether an aggressive phenotype is sustained through adaptation or resistance to mTOR inhibition remains unknown. Here, complementary studies in human tumors, cancer models and cell lines reveal transcriptional reprogramming that supports metastasis in response to mTOR inhibition. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL15207
2 Samples
Download data: CEL
Series
Accession:
GSE85801
ID:
200085801
20.

Chromatin immunoprecipitation assay of EVI1 in MCF7 and HCC1937 breast cancer cells untreated and everolimus-adapted

(Submitter supplied) Inhibitors of the mechanistic target of rapamycin (mTOR) are currently used to treat advanced metastatic breast cancer. However, whether an aggressive phenotype is sustained through adaptation or resistance to mTOR inhibition remains unknown. Here, complementary studies in human tumors, cancer models and cell lines reveal transcriptional reprogramming that supports metastasis in response to mTOR inhibition. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL14622
4 Samples
Download data: TXT
Series
Accession:
GSE50905
ID:
200050905
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