Similar studies for GEO DataSets (Select 200017661) - GEO DataSets

Select item 2000176611.

Modulation of gene expression by rapamycin in hepatic cell lines, WB-F344 and WB311

(Submitter supplied) Two rat hepatic cell lines, WB-F344 and WB311, were characterized for the effect of rapamycin on gene expression. The WB311 cell line, which is tumorigenic and resistant to the growth inhibitory effects of rapamycin, was originally derived from the WB-F344 parental hepatic epithelial cell line. The goal of this experiment was to identify genes that responded to rapamycin in the sensitive cells but not the resistant cells, thereby providing insight into the mechanism of rapamycin resistance.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL1355
12 Samples

Download data: CEL

Series

Accession:: GSE17661

ID:: 200017661

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000176772.

Modulation of gene expression by rapamycin in hepatic cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL6101 GPL1355
24 Samples

Download data: CEL

Series

Accession:: GSE17677

ID:: 200017677

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000176623.

Modulation of gene expression by rapamycin in hepatic cell lines, H5D and GN5

(Submitter supplied) Two rat hepatic cell lines, GN5 and H5D, were characterized for the effect of rapamycin on gene expression. These cells lines are tumorigenic and display intermediate sensitivity to the growth inhibitory effects of rapamycin. The goal of this experiment was to assess the effect of rapamycin on gene expression independent of effects on cell proliferation.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL6101
12 Samples

Download data: TXT

Series

Accession:: GSE17662

ID:: 200017662

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000188454.

Rapamycin effect on gene expression: dependence on c-Myc

(Submitter supplied) This experiment utilized rat fibroblasts that are wild-type for c-Myc (TGR-1 cells) and null for c-Myc (HO15.19 cells). Both were treated treated with rapamycin for 24 hr (comparison group, vehicle control).

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL6101
12 Samples

Download data: TXT, XLS

Series

Accession:: GSE18845

ID:: 200018845

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Select item 2000670225.

Regulation of Rat Hepatic Translation by mTOR

(Submitter supplied) Our strategy was to manipulate mTOR signaling in vivo, then characterize the transcriptome and translating mRNA in liver tissue. In adult rats, we used the non-proliferative growth model of refeeding after a period of fasting, and the proliferative model of liver regeneration following partial hepatectomy. We also studied livers from pre-term fetal rats (embryonic day 19-20) in which fetal hepatocytes are asynchronously proliferating. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL6247
40 Samples

Download data: CEL

Series

Accession:: GSE67022

ID:: 200067022

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Select item 2000158246.

Gene expression profiling of human gliomas and human glioblastoma cell lines

(Submitter supplied) To identify signaling pathways that are differentially regulated in human gliomas, a microarray analysis on 30 brain tumor samples (12 primary glioblastomas (GBM), 3 secondary glioblastomas (GBM-2), 8 astrocytomas (Astro) and 7 oligodendrogliomas (Oligo)) and on 5 glioblastoma cell lines (LN018, LN215, LN229, LN319 and BS149) was performed. Normal brain tissue (NB) and normal human astrocytes (NHA) were used as a control. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS4467 GDS4468
Platform:: GPL570
45 Samples

Download data: CEL

Series

Accession:: GSE15824

ID:: 200015824

Select item 44687.

Glioblastoma cell lines: LN018, LN215, LN229, LN319 and BS149

Analysis of 5 glioblastoma cell lines (LN018, LN215, LN229, LN319 and BS149). Results provide insight into molecular mechanisms underlying glioblastoma multiforme and other aggressive brain cancers.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 5 cell line sets

Platform:: GPL570
Series:: GSE15824
10 Samples

Download data: CEL

DataSet

Accession:: GDS4468

ID:: 4468

Select item 44678.

Primary and secondary brain tumors: glioblastomas, astrocytomas and oligodendrogliomas

Analysis of primary glioblastomas (GBM), astrocytomas, oligodendrogliomas and secondary GBM brain tumors. MNK1 kinase upregulation observed in primary GBM brain tumors. Results identifiy signaling pathways differentially regulated in gliomas.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 5 cell type, 8 other, 3 tissue sets

Platform:: GPL570
Series:: GSE15824
35 Samples

Download data: CEL

DataSet

Accession:: GDS4467

ID:: 4467

Select item 2000199449.

MicroRNAs and gene expression profiles of rapamycin sensitive and resistant myogenic tumor cell line

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL9939 GPL1261
21 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE19944

ID:: 200019944

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001991610.

MicroRNAs mediate rapamycin resistance in a myogenic tumor cell line

(Submitter supplied) The mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation. Inhibitors of mTOR are being evaluated as anti-tumor agents. Given the emerging role of microRNAs (miRNAs) in tumorgenesis we hypothesized that miRNAs could play important roles in the response of tumors to mTOR inhibitors. Rapamycin resistant myogenic cells developed by long-term rapamycin treatment showed extensive reprogramming of miRNAs expression, characterized by up-regulation of the mir-17~92 and related clusters and down-regulation of tumor-suppressor miRNAs. more...