Swd2/Cps35 determines H3K4 tri-methylation via interactions with Set1 and Rad6_H3K4me3 ChIPseq in WT and several strains - - GEO DataSets

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Swd2/Cps35 determines H3K4 tri-methylation via interactions with Set1 and Rad6_H3K4me3 ChIPseq in WT and several strains

(Submitter supplied) Histone H3K4 tri-methylation (H3K4me3) catalyzed by Set1/COMPASS, is a prominent epigenetic mark found in promoter-proximal regions of actively transcribed genes. H3K4me3 relies on prior monoubiquitination at the histone H2B (H2Bub) by Rad6 and Bre1. Swd2/Cps35, a Set1/COMPASS component, has been proposed as a key player in facilitating H2Bub-dependent H3K4me3. However, a more comprehensive investigation regarding the relationship among Rad6, Swd2 and Set1 is required to further understand the mechanisms and functions of the H3K4 methylation. more...

Organism:: Saccharomyces cerevisiae

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17342
7 Samples

Download data: BW

Series

Accession:: GSE261160

ID:: 200261160

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