U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 1 to 20 of 6704

1.

Identification of tumor-related genes via RNA sequencing of tumor tissues in Xenopus tropicalis

(Submitter supplied) Cancer is often caused by mutations in many genes. Although genomic studies have identified many oncogenes and tumor suppressor genes, gene sets involved in tumorigenesis remain poorly understood. Xenopus, a genus of aquatic frogs, is a useful model to identify gene sets because it can be genetically and experimentally analyzed. So we analyzed gene expression in tumor tissues of three individuals in Xenopus tropicalis and compared with that in normal tissues.
Organism:
Xenopus tropicalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30018
12 Samples
Download data: CSV
Series
Accession:
GSE233287
ID:
200233287
2.

The effects of environmentally relevant concentrations of aqueous atorvastatin on Xenopus laevis

(Submitter supplied) Numerous studies report active pharmaceutical compounds detected in both wastewater effluent and surface waters. Exposure to statin drugs in general, and atorvastatin in particular, is likely to be a concern. We hypothesized that chronic exposure to low concentrations of atorvastatin in water would result in an adverse effect on production of steroids regulating growth and development of the model amphibian Xenopus laevis. more...
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28901
6 Samples
Download data: XLSX
Series
Accession:
GSE236279
ID:
200236279
3.

Regulation of gene expression downstream of a novel Fgf/Erk pathway during Xenopus development

(Submitter supplied) Activation of Map kinase/Erk signalling downstream of fibroblast growth factor (Fgf) tyrosine kinase receptors regulates gene expression required for mesoderm induction and patterning of the anteroposterior axis during Xenopus development. We have proposed that a subset of Fgf target genes are activated in the embyo in response to inhibition of a transcriptional repressor. Here we investigate the hypothesis that Cic (Capicua), which was originally identified as a transcriptional repressor negatively regulated by receptor tyrosine kinase/Erk signalling in Drosophila, is involved in regulating Fgf target gene expression in Xenopus. more...
Organism:
Xenopus tropicalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL33301
9 Samples
Download data: TXT
Series
Accession:
GSE228699
ID:
200228699
4.

Mitotic chromosomes scale to nucleo-cytoplasmic ratio and cell size in Xenopus

(Submitter supplied) Hi-C on mitotic chromosomes in Xenopus system to study mitotic chromosome scaling by comparing replicated sperm vs stage 8 embryo chromosomes
Organism:
Xenopus laevis
Type:
Other
Platform:
GPL22393
4 Samples
Download data: MCOOL
Series
Accession:
GSE217111
ID:
200217111
5.

LCM-RNA-Seq data obtained from Xenopus tropicalis chondrocytes and osteoblasts

(Submitter supplied) LCM-RNA-Seq data obtained from Xenopus tropicalis chondrocytes and osteoblasts at different stages of differentiation -immature chondrocytes and mature (hypertrophic) chondrocytes- isolated from the ceratohyal. Osteoblasts isolated from the mandible (dentary bone).
Organism:
Xenopus tropicalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21875
9 Samples
Download data: TXT
Series
Accession:
GSE231325
ID:
200231325
6.

Age-associated DNA methylation changes in Xenopus frogs, and Targeted bisulfite sequencing to profile age-associated DNA methylation changes in Xenopus frogs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Xenopus tropicalis
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL30018
25 Samples
Download data
Series
Accession:
GSE222108
ID:
200222108
7.

Targeted bisulfite sequencing to profile age-associated DNA methylation changes in Xenopus frogs

(Submitter supplied) Here we present clear patterns of age-associated changes in DNA methylation in the aquatic vertebrate species Xenopus tropicalis. We selected approximately 3500 sites highly correlated with age from WGBS data from 9 frogs of 3 different age groups (young, approx. 1 year old; mature, approx. 5 years old; old, approx. 9 years old - GSE221656) and designed probes for the development of cost effective targeted bisulfite sequencing (TBSeq) assay. more...
Organism:
Xenopus tropicalis
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL30018
16 Samples
Download data: TXT
Series
Accession:
GSE222107
ID:
200222107
8.

Age-associated DNA methylation changes in Xenopus frogs

(Submitter supplied) Here we present clear patterns of age-associated changes in DNA methylation in the aquatic vetebrate species Xenopus tropicalis. We generated nine whole-genome bisulfite sequencing (WGBS) datasets from three distinct age groups (young, approx. 1 year old; mature, approx. 5 years old; old, approx. 9 years old) to characterize the gene- and chromosome-scale changes.
Organism:
Xenopus tropicalis
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL30018
9 Samples
Download data: TXT
Series
Accession:
GSE221656
ID:
200221656
9.

Histone deacetylase 1 maintains lineage integrity through histone acetylome refinement during early embryogenesis

(Submitter supplied) Histone acetylation is a pivotal epigenetic modification that controls chromatin structures and regulates gene expression. It plays an essential role in modulating zygotic transcription and cell lineage specification of developing embryos. While the outcomes of many inductive signals have been described to require enzymatic activities of histone acetyltransferases and deacetylases (HDACs), the mechanisms by which HDACs confines the utilization of the zygotic genome are not well-characterized. more...
Organism:
Xenopus tropicalis
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL23182 GPL30018
45 Samples
Download data: NARROWPEAK, RESULTS
Series
Accession:
GSE198378
ID:
200198378
10.

Xenopus laevis lack the critical sperm factor PLCz

(Submitter supplied) To investigate whether X. laevis have a PLCz ortholog or comparable enzyme.
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21248
3 Samples
Download data: TXT
Series
Accession:
GSE224304
ID:
200224304
11.

Comparative analysis of transcriptome profiles reveals organ-dependent (Intestine and Tail) genomic and nongenomic actions of thyroid hormone in Xenopus tropicalis tadpoles

(Submitter supplied) To investigate which genes expression are inhibited in TR double knockout tadpoles under over thyroid hormone condition in each tissue.
Organism:
Xenopus tropicalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30018
24 Samples
Download data: TXT
Series
Accession:
GSE210456
ID:
200210456
12.

RNA sequencing of wild-type liver at stage 54, stage 61, stage 66 and T3 treated liver.

(Submitter supplied) Conclusions: Our study represents the first detailed analysis of liver transcriptomes in wild-type tadpoles, with biologic replicates, generated by RNA-seq technology. The optimized data analysis workflows reported here should provide a framework for comparative investigations of expression profiles.
Organism:
Xenopus tropicalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21875
12 Samples
Download data: TXT
Series
Accession:
GSE201168
ID:
200201168
13.

Single-cell transcriptomic atlas reveals the evolution of immune cells and molecules across multiple vertebrate species

(Submitter supplied) We utilized single-cell RNA sequencing (scRNA-seq) to carry out comparative transcriptome analysis in various immune cells from the spleens across seven vertebrate species.
Organism:
Homo sapiens; Sus scrofa; Danio rerio; Macaca mulatta; Xenopus tropicalis; Mus musculus; Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
7 related Platforms
7 Samples
Download data: TAR
Series
Accession:
GSE186158
ID:
200186158
14.

A mixture of chemicals found in human amniotic fluid disrupts brain gene expression and behavior in Xenopus laevis

(Submitter supplied) We hypothesized that embryonic exposure to a mixture of chemicals (containing phenols, phthalates, pesticides, heavy metals, and perfluorinated, polychlorinated, and polybrominated compounds) identified as commonly found in the human amniotic fluid (as calculated in Fini et al., ) could lead to altered brain development. We assessed its effect on TH signaling and neuro-development in an amphibian model (Xenopus laevis) highly sensitive to thyroid disruption. more...
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21248
12 Samples
Download data: TXT
Series
Accession:
GSE223829
ID:
200223829
15.

Super-sized clustered loops anchored at transposon Helitrons in Xenopus tropicalis sperm associate with late gene expression during embryogenesis [Hi-C 2]

(Submitter supplied) Vertebrate sperm genome differs from somatic cells and undergoes dramatic transformation after fertilization. However, the functional implications of the sperm genome structures have not been fully investigated. Here we show, in the sperms of Xenopus tropicalis, tens of genomic regions harbor multi-megabases, super-sized clustered loops (SSCLs) whose anchors are enriched with Helitrons, the only group of rolling-circle transposons. more...
Organism:
Xenopus laevis
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL31294
2 Samples
Download data: HIC
Series
Accession:
GSE218519
ID:
200218519
16.

Super-sized clustered loops anchored at transposon Helitrons in Xenopus tropicalis sperm associate with late gene expression during embryogenesis [ChIP-Seq2]

(Submitter supplied) Vertebrate sperm genome differs from somatic cells and undergoes dramatic transformation after fertilization. However, the functional implications of the sperm genome structures have not been fully investigated. Here we show, in the sperms of Xenopus tropicalis, tens of genomic regions harbor multi-megabases, super-sized clustered loops (SSCLs) whose anchors are enriched with Helitrons, the only group of rolling-circle transposons. more...
Organism:
Xenopus tropicalis
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL30213
8 Samples
Download data: BW
Series
Accession:
GSE218515
ID:
200218515
17.

Super-sized clustered loops anchored at transposon Helitrons in Xenopus tropicalis sperm associate with late gene expression during embryogenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Xenopus laevis; Xenopus tropicalis; Xenopus tropicalis x Xenopus laevis
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
4 related Platforms
67 Samples
Download data: BW, COOL, HIC, TXT
Series
Accession:
GSE197877
ID:
200197877
18.

Super-sized clustered loops anchored at transposon Helitrons in Xenopus tropicalis sperm associate with late gene expression during embryogenesis [RNA-Seq]

(Submitter supplied) Vertebrate sperm genome differs from somatic cells and undergoes dramatic transformation after fertilization. However, the functional implications of the sperm genome structures have not been fully investigated. Here we show, in the sperms of Xenopus tropicalis, tens of genomic regions harbor multi-megabases, super-sized clustered loops (SSCLs) whose anchors are enriched with Helitrons, the only group of rolling-circle transposons. more...
Organism:
Xenopus tropicalis x Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL32016
26 Samples
Download data: TXT
Series
Accession:
GSE197874
ID:
200197874
19.

Super-sized clustered loops anchored at transposon Helitrons in Xenopus tropicalis sperm associate with late gene expression during embryogenesis [Hi-C]

(Submitter supplied) Vertebrate sperm genome differs from somatic cells and undergoes dramatic transformation after fertilization. However, the functional implications of the sperm genome structures have not been fully investigated. Here we show, in the sperms of Xenopus tropicalis, tens of genomic regions harbor multi-megabases, super-sized clustered loops (SSCLs) whose anchors are enriched with Helitrons, the only group of rolling-circle transposons. more...
Organism:
Xenopus tropicalis; Xenopus tropicalis x Xenopus laevis
Type:
Other
Platforms:
GPL30213 GPL32015
8 Samples
Download data: COOL, HIC
Series
Accession:
GSE197873
ID:
200197873
20.

Super-sized clustered loops anchored at transposon Helitrons in Xenopus tropicalis sperm associate with late gene expression during embryogenesis [ATAC-Seq]

(Submitter supplied) Vertebrate sperm genome differs from somatic cells and undergoes dramatic transformation after fertilization. However, the functional implications of the sperm genome structures have not been fully investigated. Here we show, in the sperms of Xenopus tropicalis, tens of genomic regions harbor multi-megabases, super-sized clustered loops (SSCLs) whose anchors are enriched with Helitrons, the only group of rolling-circle transposons. more...
Organism:
Xenopus tropicalis
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL30213
3 Samples
Download data: BW
Series
Accession:
GSE197867
ID:
200197867
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=xenopus[Organism]|query=1|qty=108|blobid=MCID_6515d1f74300ad48fb7d5d2a|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center