U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 1 to 20 of 7154

1.

Interactions between genistein and Wnt pathway in colon adenocarcinoma and early embryos

(Submitter supplied) The Wnt signaling pathway is one of the most ancient and pivotal signaling cascades, governing diverse processes in development and cancer regulation. Within the realm of cancer treatment, genistein emerges as a promising candidate due to its multifaceted modulation of various signaling pathways, including the Wnt pathway. Despite promising preclinical studies, the precise mechanisms underlying genistein's therapeutic effects via Wnt modulation remain elusive. more...
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL34551
12 Samples
Download data: TXT
Series
Accession:
GSE268980
ID:
200268980
2.

Maternal and zygotic factors sequentially shape the tissue regionalization of chromatin landscapes in early vertebrate embryos

(Submitter supplied) ChIP-seq and RNA-seq analyses to understand the establishment of the cis-regulatory mark H3K4me1 during early embryogenesis.
Organism:
Xenopus tropicalis
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL23182 GPL30018
26 Samples
Download data: NARROWPEAK, TXT
Series
Accession:
GSE172395
ID:
200172395
3.

Mucociliary epidermis RNA-seq data from controls during early patterning (st. 14-20)

(Submitter supplied) This study was conducted to investigate the temporal expression of patterning genes in the Xenopus mucociliary epidermis.
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22393
6 Samples
Download data: TABULAR, TXT
Series
Accession:
GSE262944
ID:
200262944
4.

Effect of erythropoietin on the gene expression of Xenopus tropicalis peripheral blood cells.

(Submitter supplied) The regulatory system of erythropoiesis through erythropoietin (EPO) and its receptor (EPOR) is essential for vertebrates' life. In humans, EPO affects the erythroid progenitors and stimulates proliferation and differentiation. The EPO-EPOR axis is mainly mediated by the JAK2-STAT5 pathway. After terminal maturation, erythrocytes lost EPOR expression; however, erythrocytes of amphibian Xenopus tropicalis maintain EPOR expression even after their terminal maturation. more...
Organism:
Xenopus tropicalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30213
15 Samples
Download data: CSV
Series
Accession:
GSE251901
ID:
200251901
5.

From neural border epithelium to neural crest emigration: A comprehensive single cell roadmap of the timing and regulatory logic underlying cranial and vagal neural crest emergence

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Xenopus laevis; Xenopus tropicalis
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL21875 GPL30018 GPL18936
35 Samples
Download data
Series
Accession:
GSE198494
ID:
200198494
6.

From neural border epithelium to neural crest emigration: A comprehensive single cell roadmap of the timing and regulatory logic underlying cranial and vagal neural crest emergence [morpholinoRNAseq]

(Submitter supplied) Neural crest cells exemplify cellular diversification from a multipotent progenitor population. However, the full sequence of molecular choices governing the emergence of neural crest heterogeneity from the ectoderm remains elusive. Gene regulatory networks govern these steps of embryonic development and cell specification towards definitive neural crest. Here, we combine ultra-dense single cell transcriptomes with machine-learning strategies and experimental validation to provide a comprehensive gene regulatory network driving vertebrate neural crest fate diversification, from induction to early migration stages. more...
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18936
10 Samples
Download data: CSV
Series
Accession:
GSE198493
ID:
200198493
7.

From neural border epithelium to neural crest emigration: A comprehensive single cell roadmap of the timing and regulatory logic underlying cranial and vagal neural crest emergence [ChIPseq]

(Submitter supplied) Neural crest cells exemplify cellular diversification from a multipotent progenitor population. However, the full sequence of molecular choices governing the emergence of neural crest heterogeneity from the ectoderm remains elusive. Gene regulatory networks govern these steps of embryonic development and cell specification towards definitive neural crest. Here, we combine ultra-dense single cell transcriptomes with machine-learning strategies and experimental validation to provide a comprehensive gene regulatory network driving vertebrate neural crest fate diversification, from induction to early migration stages. more...
Organism:
Xenopus laevis; Xenopus tropicalis
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL18936 GPL21875
23 Samples
Download data: CSV
Series
Accession:
GSE198492
ID:
200198492
8.

From neural border epithelium to neural crest emigration: A comprehensive single cell roadmap of the timing and regulatory logic underlying cranial and vagal neural crest emergence [scRNAseq]

(Submitter supplied) Neural crest cells exemplify cellular diversification from a multipotent progenitor population. However, the full sequence of molecular choices governing the emergence of neural crest heterogeneity from the ectoderm remains elusive. Gene regulatory networks govern these steps of embryonic development and cell specification towards definitive neural crest. Here, we combine ultra-dense single cell transcriptomes with machine-learning strategies and experimental validation to provide a comprehensive gene regulatory network driving vertebrate neural crest fate diversification, from induction to early migration stages. more...
Organism:
Xenopus tropicalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30018
2 Samples
Download data: PKL
Series
Accession:
GSE198491
ID:
200198491
9.

RNAseq analysis of Xenopus laevis wildtype and emi2 mutant multiciliated cells during and post differentiation

(Submitter supplied) Multiciliated cells (MCCs) form when progenitors massively expand centriole number, yielding the hundreds of basal bodies required to extend multiple motile cilia. This organelle biogenesis is promoted transcriptionally by Multicilin acting in a complex with the E2F transcription factors, which activates the expression of genes known to be involved required to form centrioles during the cell cycle, but also requires a cell cycle state required for the centrosome cycle. more...
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18936
12 Samples
Download data: XLSX
Series
Accession:
GSE195635
ID:
200195635
10.

Sf3b4 mutation in Xenopus tropicalis causes RNA splicing defects and gene dysregulation across development and disrupts cranial neural crest cell migration and survival

(Submitter supplied) Nager syndrome is a rare craniofacial and limb disorder characterized by midface retrusion, micrognathia, absent thumbs, and radial hypoplasia. This disorder results from haploinsufficiency of SF3B4 (splicing factor 3b, subunit 4) a component of the pre-mRNA spliceosomal machinery. The spliceosome is a complex of RNA and proteins that function together to remove introns and join exons from transcribed pre-mRNA. more...
Organism:
Xenopus tropicalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30018
17 Samples
Download data: TXT
Series
Accession:
GSE249075
ID:
200249075
11.

Control of poly(A)-tail length and translation in vertebrate oocytes and early embryos

(Submitter supplied) During oocyte maturation and early embryonic development, poly(A)-tail lengths strongly influence mRNA translation. However, how tail lengths are controlled at different developmental stages has been unclear. Here, we performed tail-length and translational profiling of mRNA reporter libraries (each with > 10 million 3ʹ-UTR sequence variants) in frog oocytes and embryos, and fish embryos. These analyses revealed that the UUUUA motif specifies cytoplasmic polyadenylation and identified diverse context features that modulate the activity of this 5-mer. more...
Organism:
Danio rerio; Mus musculus; Xenopus laevis; synthetic construct
Type:
Other
4 related Platforms
83 Samples
Download data: TXT
Series
Accession:
GSE241107
ID:
200241107
12.

Transcriptomic analyses identify pathways linking developmental atrazine exposure to altered intestine development

(Submitter supplied) Purpose: Identify gene expression changes in whole intestines of Xenopus laevis embryos exposed to atrazine (35 mg/L) compared to DMSO controls Methods: NF 39 embryos were exposed to 35 mg/L ATR or DMSO control for 24 hours. After 24 hours of exposure, intestines from embryos of each treatment group were dissected from anesthetized embryos with sharpened forceps. The anterior portion of the embryo (including the head, heart, and foregut) were removed and discarded, leaving only the mid-and hindgut portion of the intestine. more...
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28901
8 Samples
Download data: CSV
Series
Accession:
GSE226434
ID:
200226434
13.

Identification of genes regulated by mechanical tension in Xenopus laevis explants by transcriptome comparison

(Submitter supplied) During gastrulation and neurulation, the chordamesoderm and overlying neuroectoderm of vertebrate embryos converge under the control of a specific genetic programme to the dorsal midline, simultaneously extending along it. However, whether mechanical tensions resulting from these morphogenetic movements play a role in long-range feedback signalling that in turn regulates gene expression in the chordamesoderm and neuroectoderm is unclear. more...
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21046
6 Samples
Download data: XLSX
Series
Accession:
GSE246027
ID:
200246027
14.

BRCA1 and ELK-1 regulate Neural Progenitor Cell Fate in the Optic Tectum in response to Visual Experience in Xenopus laevis tadpoles 

(Submitter supplied) To identify regulators of activity-dependent neural progenitor cell fate, we used RNA-Seq to profile the transcriptomes of proliferating neural progenitor cells and newly-differentiated immature neurons. We identified six DE transcription factors which are predicted to regulate the majority of the other DE transcripts. We investigated the effect of BRCA1 and ELK-1 on activity-regulated neurogenesis in the tadpole visual system and found that knockdown of either BRCA1 or ELK-1 altered the fates of neural progenitor cells, and furthermore that the effects of visual experience on neurogenesis depend on BRCA1 expression, while the effects of visual experience on neuronal differentiation depend on ELK-1 expression. more...
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17682
6 Samples
Download data: FA, GFF3, XLSX
Series
Accession:
GSE184315
ID:
200184315
15.

EcoToxChip 2016 LSARP RNASeq database

(Submitter supplied) As part of the EcoToxChip project, 49 distinct exposure studies were conducted on three lab model species (Japanese quail, fathead minnow, African clawed frog) and three ecologically relevant species (double crested cormorant, rainbow trout, northern leopard frog), at multiple life stages (embryo, adult), exposed to eight chemicals of environmental concern (ethinyl estradiol-EE2, hexabromocyclododecane-HBCD, lead-Pb, selenomethionine-SeMe, 17β trenbolone-TB, chlorpyrifos-CPF, fluoxetine-FLX, and benzo [a] pyrene-BaP. more...
Organism:
Oncorhynchus mykiss; Xenopus laevis; Coturnix japonica; Lithobates pipiens; Phalacrocorax auritus; Pimephales promelas
Type:
Expression profiling by high throughput sequencing
9 related Platforms
724 Samples
Download data: TXT
Series
Accession:
GSE239776
ID:
200239776
16.

Embryos Assist Each Other’s Morphogenesis: calcium and ATP signaling mechanisms in collective resistance to teratogens

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18936
24 Samples
Download data
Series
Accession:
GSE245782
ID:
200245782
17.

Embryos Assist Each Other’s Morphogenesis: calcium and ATP signaling mechanisms in collective resistance to teratogens (Stage 35)

(Submitter supplied) We investigated whether normal embryonic developmental cues are only at the level of cells within the embryo or whether they exist in interactions between embryos. To explore this, we subjected groups of embryos with disruptors of normal development while varying group size. RNA-seq analysis revealed a small set of transcripts specific for teratogen response in large groups but not small ones.
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18936
12 Samples
Download data: CSV, TSV
Series
Accession:
GSE245781
ID:
200245781
18.

Embryos Assist Each Other’s Morphogenesis: calcium and ATP signaling mechanisms in collective resistance to teratogens (Stage 25)

(Submitter supplied) We investigated whether normal embryonic developmental cues are only at the level of cells within the embryo or whether they exist in interactions between embryos. To explore this, we subjected groups of embryos with disruptors of normal development while varying group size. RNA-seq analysis revealed a small set of transcripts specific for teratogen response in large groups but not small ones.
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18936
12 Samples
Download data: TSV, XLSX
Series
Accession:
GSE245780
ID:
200245780
19.

Characterization of regeneration initiating cells during Xenopus laevis tail regeneration

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL21248 GPL28901
63 Samples
Download data: CSV, JPG, JSON, MTX, PNG, TSV, XLSX
Series
Accession:
GSE245320
ID:
200245320
20.

Characterization of regeneration initiating cells during Xenopus laevis tail regeneration [bulk RNA-Seq 2]

(Submitter supplied) In this experiment, we revealed the critical steps for regeneration initiation. We discovered Regeneration Initiating Cells (RICs) using single cell and spatial transcriptomics of the regenerating Xenopus laevis tail. RICs are formed transiently from the basal epidermal cells and are critical for the modification of the surrounding extracellular matrix to allow for migration of other cell types that promote regeneration. more...
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21248
32 Samples
Download data: XLSX
Series
Accession:
GSE245318
ID:
200245318
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=xenopus[Organism]|query=1|qty=112|blobid=MCID_666a283eac4a2c10508b8ac8|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center