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Items: 1 to 20 of 3466

1.
Full record GDS3996

Transcription factor Regulatory factor X 6 knockdown effect on tadpole anterior gut: time course

Transcription factor Regulatory factor X 6 knockdown effect on tadpole anterior gut: time course Summary: Analysis of tadpole gut at various developmental stages (NF30, NF40, NF44), following morpholino-induced knockdown of rfx6 in embryos. Rfx6 mutations are associated with neonatal diabetes and ot
Organism:
Xenopus laevis
Type:
Expression profiling by array, count, 3 development stage, 2 protocol sets
Platform:
GPL10756
Series:
GSE23642
18 Samples
Download data: CEL, CHP
2.
Full record GDS2567

Banded hedgehog effect on the pronephric nephron development

Analysis of pronephric explants dissected from embryos previously injected with banded hedgehog mRNA. Hedgehog suppresses the development of the pronephric kidney tubule but not that of the pronephric glomus. Results provide insight into the molecular basis of this inhibitory effect.
Organism:
Xenopus laevis
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL1318
Series:
GSE3712
6 Samples
Download data
DataSet
Accession:
GDS2567
ID:
2567
3.
Full record GDS2301

Noggin and Dkk-1 ectopic expression effect on ventral mesoderm during gastrulation

Analysis of stage 10 early and stage 11.5 late gastrula embryos ectopically expressing Noggin, Dkk-1, or both to induce different aspects of organizer activity. The organizer patterns vertebrate embryos during gastrulation. Results provide insight into organizer function during gastrulation.
Organism:
Xenopus laevis
Type:
Expression profiling by array, count, 4 agent, 2 development stage, 4 other, 2 tissue sets
Platform:
GPL1318
Series:
GSE3368
20 Samples
Download data: CEL
4.
Full record GDS2120

Dominant negative thyroid hormone receptor overexpression effect on hind limb muscle development

Analysis of hind limbs of premetamorphic (NF55) and postmetamorphic (NF66) transgenics 2 or 6 weeks following transcriptional induction of a dominant negative thyroid hormone (TH) receptor transgene. Results provide insight into the role of TH in the maintenance of limb muscle during development.
Organism:
Xenopus laevis
Type:
Expression profiling by array, log10 ratio, 2 development stage, 2 genotype/variation, 2 time sets
Platform:
GPL3936
Series:
GSE5249
12 Samples
Download data: TXT
5.
Full record GDS2016

Nodal, Mixer, and Sox17 inactivation effect on gastrula stage embryo

Analysis of stage 11 embryos inactivated for Nodal signaling, or depleted of Mixer or Sox17 proteins. Microdissected animal caps and vegetal and equatorial regions of stage 11 embryos also examined. Nodal, Mixer, and Sox17 are key proteins of a pathway controlling endoderm formation.
Organism:
Xenopus laevis
Type:
Expression profiling by array, count, 3 development stage, 8 tissue sets
Platform:
GPL1318
Series:
GSE4448
31 Samples
Download data: CEL
DataSet
Accession:
GDS2016
ID:
2016
6.
Full record GDS1719

Thyroid hormone triiodothyronine effect on tadpole tail: time course

Analysis of tails of NF stage 54 (NF54) premetamorphic tadpoles treated with thyroid hormone (TH) triiodothyronine (T3) up to 48 hours. NF61 tadpoles were in 0.1xMMR till they reached NF62. Premetamorphic tails are resorbed in response to TH. Results identify genes involved in TH-induced resorption.
Organism:
Xenopus laevis; unidentified
Type:
Expression profiling by array, log ratio, 2 agent, 2 development stage, 3 time sets
Platform:
GPL2901
Series:
GSE3405
12 Samples
Download data: TIFF
DataSet
Accession:
GDS1719
ID:
1719
7.
Full record GDS1718

Thyroid hormone triiodothyronine effect on tadpole limb bud: time course

Analysis of limb buds of NF stage 54 (NF54) premetamorphic tadpoles treated with thyroid hormone (TH) triiodothyronine (T3) for 14, 24 or 48 hours. Premetamorphic limb buds proliferate and differentiate in response to TH. Results identify genes involved in the TH-induced proliferation pathway.
Organism:
Xenopus laevis; unidentified
Type:
Expression profiling by array, log ratio, 2 agent, 3 time sets
Platform:
GPL2901
Series:
GSE3404
12 Samples
Download data: TIFF
DataSet
Accession:
GDS1718
ID:
1718
8.
Full record GDS1717

Thyroid hormone triiodothyronine effect on tadpole brain: time course

Analysis of brains of NF stage 54 (NF54) premetamorphic tadpoles treated with thyroid hormone (TH) triiodothyronine (T3) for 24 or 48 hours. Premetamorphic brain ventricle cells proliferate and differentiate in response to TH. Results identify genes involved in the TH-induced proliferation pathway.
Organism:
Xenopus laevis; unidentified
Type:
Expression profiling by array, log ratio, 2 agent, 2 time sets
Platform:
GPL2901
Series:
GSE3402
9 Samples
Download data: TIFF
DataSet
Accession:
GDS1717
ID:
1717
9.
Full record GDS1715

Transcription factors Mixer and Sox17beta expression effect on naïve ectodermal tissue

Analysis of naïve ectodermal tissue excised from embryos injected with Mixer or Sox17beta mRNA. Mixer and Sox17beta are important in endoderm specification during embryogenesis. Results provide insight into the molecular mechanisms underlying the regulation of endoderm development.
Organism:
Xenopus laevis
Type:
Expression profiling by array, transformed count, 3 genotype/variation sets
Platform:
GPL1318
Series:
GSE3334
6 Samples
Download data: CEL
10.

Usage of Alternative Polyadenylation Sites Differs Dramatically Between Male and Female Xenopus tropicalis.

(Submitter supplied) We applied our recently released Whole Transcriptome Termini Site sequencing protocol to profile usage of alternative polyadenylation sites in Xenopus tropicalis.
Organism:
Xenopus tropicalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22604
4 Samples
Download data: TXT
Series
Accession:
GSE89165
ID:
200089165
11.

Transcriptome analysis of Xenopus orofacial tissues deficient in retinoic acid receptor function

(Submitter supplied) Xenopus laevis embryos were treated with a retinoic acid inhibitior during early orofacial development. The facial tissues were dissected, removing eye and brain tissue from the analysis. RA regulates midface development, we sought to determine global changes in gene expression when RA function is pharmacologically disrupted
Organism:
Xenopus laevis
Type:
Expression profiling by array
Platform:
GPL10756
4 Samples
Download data: CEL
Series
Accession:
GSE115148
ID:
200115148
12.

Transcriptome analysis of wild type and RAR deficient frog faces during development

(Submitter supplied) We utilized RNASeq to investigate the changes in mRNA expression when retinoic acid signaling is inhibited by treatment with an RAR inhibitor, BMS453.
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22393
6 Samples
Download data: CSV, TXT
Series
Accession:
GSE116819
ID:
200116819
13.

Regulation of kidney field specification by transcriptional regulation of microRNAs

(Submitter supplied) The transcriptional events driving specification of the kidney field have been well characterized. However, it remains unknown how the initial field size is established, patterned, and proportioned. Lhx1 is a transcription factor expressed in the kidney anlage and is required for specification of the kidney field, but few Lhx1 interacting cofactors or downstream targets have been identified. By tandem-affinity purification, we isolated Furry (FRY), a multifunctional protein that acts as a transcriptional co-repressor of microRNAs. more...
Organism:
Xenopus laevis
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL14834
3 Samples
Download data: XLS
Series
Accession:
GSE100434
ID:
200100434
14.

The Xenopus animal cap transcriptome: building a mucociliary epithelium.

(Submitter supplied) Here we investigate dynamics of the RNA landscape during formation of the Xenopus tropicalis larval epidermis. To obtain RNA expression data, we used ectodermal explants (Animal Caps), which differentiate autonomously into a ciliated epidermis, highly related to the one in human airways. Animal caps were harvested at the gastrula neurula and tailbud stage.
Organism:
Xenopus tropicalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23182
3 Samples
Download data: TXT
Series
Accession:
GSE111171
ID:
200111171
15.

RARγ is required for mesodermal gene expression prior to gastrulation

(Submitter supplied) The developing vertebrate embryo is exquisitely sensitive to retinoic acid (RA) concentration, particularly during anteroposterior patterning. In contrast to Nodal and Wnt signaling, RA was not previously considered to be an instructive signal in mesoderm formation during gastrulation. Here we show that RARγ is indispensable for the expression of early mesoderm markers and is, therefore, an obligatory factor in mesodermal competence and/or maintenance. more...
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25501
24 Samples
Download data: XLSX
Series
Accession:
GSE119124
ID:
200119124
16.

Deficiency in SUMOylation, by injection of Gam1 mRNA into one cell embryos, leads to differential expression of genes in Xenopus

(Submitter supplied) Background: Adenovirus protein Gam1 triggers the proteolytic destruction of the E1 SUMO-activating enzyme. Microinjection of an empirically determined amount of Gam1 mRNA into one-cell Xenopus embryos can reduce SUMOylation activity to undetectable, but nonlethal levels, enabling an examination of the role of this post-translational modification during early vertebrate development. Results: We find that SUMOylation-deficient embryos consistently exhibit defects in neural tube and heart development. more...
Organism:
Xenopus laevis
Type:
Expression profiling by array
Platform:
GPL10756
18 Samples
Download data: CEL
Series
Accession:
GSE116164
ID:
200116164
17.

ERK3 is essential for establishment of epithelial architecture

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Xenopus laevis
Type:
Expression profiling by array
Platform:
GPL10756
12 Samples
Download data: CEL
Series
Accession:
GSE110429
ID:
200110429
18.

ERK3 is essential for establishment of epithelial architecture [ERK3 KD vs. TFAP2A KD]

(Submitter supplied) Establishment and maintenance of epithelial architecture are essential for embryonic development and adult physiology. Here, we show that ERK3, a poorly characterized atypical MAPK, regulates epithelial architecture in vertebrates. In Xenopus embryonic epidermal epithelia, ERK3 knockdown impairs adherens and tight junction protein distribution, as well as tight junction barrier function, resulting in epidermal breakdown. more...
Organism:
Xenopus laevis
Type:
Expression profiling by array
Platform:
GPL10756
6 Samples
Download data: CEL
Series
Accession:
GSE110428
ID:
200110428
19.

ERK3 is essential for establishment of epithelial architecture [ERK3 KD]

(Submitter supplied) Establishment and maintenance of epithelial architecture are essential for embryonic development and adult physiology. Here, we show that ERK3, a poorly characterized atypical MAPK, regulates epithelial architecture in vertebrates. In Xenopus embryonic epidermal epithelia, ERK3 knockdown impairs adherens and tight junction protein distribution, as well as tight junction barrier function, resulting in epidermal breakdown. more...
Organism:
Xenopus laevis
Type:
Expression profiling by array
Platform:
GPL10756
6 Samples
Download data: CEL
Series
Accession:
GSE110427
ID:
200110427
20.

RNA-Seq analysis of localization along animal-vegetal axis of Xenopus laevis

(Submitter supplied) We combined cryosectining of oocytes along the animal-vegetal axis (first developmental axis) and RNA-Seq to determine localization profiles of coding and noncoding RNAs. It provides complete view on RNA localization. We found that nearly all RNAs are localized, but only small percentage is actively transported during oogenesis.
Organism:
Xenopus laevis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17682
15 Samples
Download data: TXT
Series
Accession:
GSE104848
ID:
200104848
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