txid1383439[Organism:noexp] - GEO DataSets

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Select item 2002819921.

Identification of potent biparatopic antibodies targeting FGFR2 fusion driven cholangiocarcinoma

(Submitter supplied) Translocations involving FGFR2 gene fusions are common in cholangiocarcinoma and predict response to FGFR kinase inhibitors. However, response rates and durability of are limited due to the emergence of resistance, typically involving FGFR2 kinase domain mutations, and to sub-optimal dosing, relating to drug adverse effects. Here, we develop biparatopic antibodies targeting the FGFR2 extracellular domain (ECD), as candidate therapeutics. more...

Organism:: Homo sapiens/Mus musculus xenograft

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32635
20 Samples

Download data: CSV, TSV

Series

Accession:: GSE281992

ID:: 200281992

PubMed

Select item 2002823862.

CD133+PD-L1+ cancer cells confer resistance to adoptively transferred engineered macrophage-based therapy in melanoma

(Submitter supplied) Adoptive transfer of genetically or nanoparticle-engineered macrophages represents a promising cell therapy modality for treatment of solid tumor. However, the therapeutic efficacy is suboptimal without achieving a complete tumor regression, and the underlying mechanism remains elusive. Here, we discover a subpopulation of cancer cells with upregulated CD133 and programmed death-ligand 1 in mouse melanoma, resistant to the phagocytosis by the transferred macrophages. more...

Organism:: Homo sapiens/Mus musculus xenograft

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32635
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE282386

ID:: 200282386

PubMed

Select item 2002445483.

CD47 blockade synergizes with doxorubicin in enhancing macrophage phagocytosis of Ewing sarcoma cells and deceasing xenograft tumor growth and metastasis in an orthotopic model of Ewing sarcoma

(Submitter supplied) Macrophages are immune cells whose major functions include phagocytosing tumor cells. However, tumors escape macrophage phagocytosis through the expression of anti-phagocytic signals, most commonly CD47. Moreover, in Ewing sarcoma (ES), we found that tumor cells utilize dual mechanisms to evade macrophage clearance by simultaneously over-expressing CD47 and down-regulating cell surface calreticulin (csCRT), the pro-phagocytic signal. more...

Organism:: Homo sapiens/Mus musculus xenograft

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32635
20 Samples

Download data: SF

Series

Accession:: GSE244548

ID:: 200244548

PubMed Full text in PMC Similar studies

Select item 2002126714.

Transcriptome-wide analysis of CRISPR-edited iPSC-derived glioma models

(Submitter supplied) CRISPR-edited human induced pluripotent stem cell (iPSC)-derived glioma models provide a robust platform to investigate the biology of these aggressive tumors in an isogenic background or to test possible treatments in preclinical settings. We created iPSC12 lines that carry different combinations of glioma driver mutations using CRISPR/Cas9 genome editing technology, including TP53-/-, ATRX-/-, IDH1-R132H/WT, PTEN-/-, CDKN2A/B-/-, TERT promoter(TERTp) C228T/WT, MTAP-/-, and overexpression (OE) of EGFRvIII oncogenic isoform. more...

Organism:: Homo sapiens; Homo sapiens/Mus musculus xenograft

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL32635
20 Samples

Download data: TXT

Series

Accession:: GSE212671

ID:: 200212671

Select item 2002078865.

Construction of GBM patient-derived xenograft mouse models

(Submitter supplied) Our adult GBM patient-derived xenograft mouse models keep the genomics characteristics of GBM patient tumors.

Organism:: Homo sapiens/Mus musculus xenograft; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL16791 GPL32469
27 Samples

Download data: TXT

Series

Accession:: GSE207886

ID:: 200207886

PubMed Full text in PMC Similar studies

Select item 2002189156.

Interaction between tumor cell TNFR2 and monocyte membrane-bound TNFα triggers tumorigenic inflammation in neuroblastoma

(Submitter supplied) We found that NB expression of TNFR2 and monocyte mTNFα are required for monocyte activation and IL-6 production, while NB TNFR1 and monocyte sTNFα are required for NB NF-κB activation. Treatment of NB-monocyte co-cultures with clinical-grade etanercept completely abrogated release of IL-6, G-CSF, IL-1α, and IL-1β and eliminated monocyte-induced enhancement of NB cell proliferation in vitro. Furthermore, etanercept treatment inhibited tumor growth, ablated tumor angiogenesis, and suppressed oncogenic signaling in mice with subcutaneous NB/human monocyte xenografts. more...