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Items: 1 to 20 of 4264

1.

Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons

(Submitter supplied) Frontotemporal dementia (FTD) is an incurable group of early-onset dementias that can be caused by deposition of hyperphosphorylated tau in patient brains. However, the mechanisms leading to neurodegeneration remain largely unknown. Here, we combined single-cell analyses of FTD patient brains with a stem cell culture and transplantation model of FTD. We identified disease phenotypes in FTD neurons carrying the MAPT-N279K mutation, which were related to oxidative stress, oxidative phosphorylation and neuroinflammation with an upregulation of the inflammation-associated protein osteopontin (OPN). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
21 Samples
Download data: TXT
Series
Accession:
GSE230519
ID:
200230519
2.

Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons

(Submitter supplied) Frontotemporal dementia (FTD) is an incurable group of early-onset dementias that can be caused by deposition of hyperphosphorylated tau in patient brains. However, the mechanisms leading to neurodegeneration remain largely unknown. Here, we combined single-cell analyses of FTD patient brains with a stem cell culture and transplantation model of FTD. We identified disease phenotypes in FTD neurons carrying the MAPT-N279K mutation, which were related to oxidative stress, oxidative phosphorylation and neuroinflammation with an upregulation of the inflammation-associated protein osteopontin (OPN). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
22 Samples
Download data: CSV
Series
Accession:
GSE230450
ID:
200230450
3.

Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons

(Submitter supplied) Frontotemporal dementia (FTD) is an incurable group of early-onset dementias that can be caused by deposition of hyperphosphorylated tau in patient brains. However, the mechanisms leading to neurodegeneration remain largely unknown. Here, we combined single-cell analyses of FTD patient brains with a stem cell culture and transplantation model of FTD. We identified disease phenotypes in FTD neurons carrying the MAPT-N279K mutation, which were related to oxidative stress, oxidative phosphorylation and neuroinflammation with an upregulation of the inflammation-associated protein osteopontin (OPN). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17930
18 Samples
Download data: CEL
Series
Accession:
GSE230447
ID:
200230447
4.

Two distinct Trypanosoma eIF4F complexes co-exist, bind different mRNAs and are regulated during nutritional stress

(Submitter supplied) Many eIF4F subunits and PABP paralogues are found in trypanosomes: six eIF4E, five eIF4G, one eIF4A and two PABPs. They are expressed simultaneously and assemble into different complexes, contrasting the situation in metazoans that use distinct complexes in different cell types or developmental stages. Each eIF4F complex has its own proteins, mRNAs and, consequently, a distinct function. We set out to study the function and regulation of the two major eIF4F complexes of Trypanosoma cruzi. more...
Organism:
Trypanosoma cruzi
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL34379
65 Samples
Download data: TXT
Series
Accession:
GSE263777
ID:
200263777
5.

Microbial infection instigates tau-related pathology via activating neuroimmune cGAS-STING pathway

(Submitter supplied) Microbial infection, the strong trigger to directly induce inflammation in brain, is long considered a risk factor of Alzheimer’s disease, but how these infections contribute to neurodegeneration remains underexplored. Using a modified herpesvirus potentially relevant to this disease, we found that its infection promotes tau-related pathology in part via activating neuroimmune cGAS-STING pathway in the tau mouse models. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21273
10 Samples
Download data: TSV
Series
Accession:
GSE229411
ID:
200229411
6.

Human iPSC 4R tauopathy model uncovers modifiers of tau propagation [scRNA-seq]

(Submitter supplied) Tauopathies are age-associated neurodegenerative diseases whose mechanistic underpinnings remain elusive, partially due to lack of appropriate human models. Here, we engineered new human induced pluripotent stem cell (hiPSC)-derived neuronal lines to express 4R Tau and 4R Tau carrying the P301S MAPT mutation when differentiated into neurons. 4R-P301S neurons display progressive Tau inclusions upon seeding with Tau fibrils and recapitulate features of tauopathy phenotypes including shared transcriptomic signatures, autophagic body accumulation, and reduced neuronal activity. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
3 Samples
Download data: MTX, TSV
Series
Accession:
GSE255904
ID:
200255904
7.

Human iPSC 4R tauopathy model uncovers modifiers of tau propagation [bulk RNA-seq]

(Submitter supplied) Tauopathies are age-associated neurodegenerative diseases whose mechanistic underpinnings remain elusive, partially due to lack of appropriate human models. Here, we engineered new human induced pluripotent stem cell (hiPSC)-derived neuronal lines to express 4R Tau and 4R Tau carrying the P301S MAPT mutation when differentiated into neurons. 4R-P301S neurons display progressive Tau inclusions upon seeding with Tau fibrils and recapitulate features of tauopathy phenotypes including shared transcriptomic signatures, autophagic body accumulation, and reduced neuronal activity. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
19 Samples
Download data: CSV
Series
Accession:
GSE255902
ID:
200255902
8.

APOE-Ɛ4 astrocytes exhibit deficits in endocytic uptake that contribute to the delayed maturation of neuronal network activity and alter neuronal tau uptake in co-cultures of human iPSC-derived brain cells

(Submitter supplied) To explore the mechanistic basis of ApoE Ɛ4 vs ApoE Ɛ3 protein expression on endocytic pathways responsible for tau uptake in neurons and astrocytes and the maturation of neuronal networks, we have developed genotype matched co-cultures of iPSC derived astrocytes and neurons derived from isogenic triads of iPSC lines generated by the ADAPTED consortium (Schmid et al., 2019, 2020) . We show that isogenic iPSC derived APOE-E4 expressing astrocytes take up less extracellular tau than APOE-E3 or APOE null astrocytes, while isogenic neurons in monoculture take up equivalent amounts of tau primarily through macropinocytosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
47 Samples
Download data: TXT
Series
Accession:
GSE171700
ID:
200171700
9.

Early amyloid-induced changes in microglia gene expression in APP/PS1 mice [scRNA-seq]

(Submitter supplied) Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia, characterized by deposition of extracellular amyloid-beta (Aβ) aggregates and intraneuronal hyperphosphorylated Tau. Many AD risk genes, identified in genome-wide association studies (GWAS), are expressed in microglia, the innate immune cells of the central nervous system. Specific subtypes of microglia emerged in relation to AD pathology, such as disease-associated microglia (DAMs), which increased in number with age in amyloid mouse models and in human AD cases. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
36 Samples
Download data: TXT
Series
Accession:
GSE226938
ID:
200226938
10.

Early amyloid-induced changes in microglia gene expression in APP/PS1 mice [bulk RNA-seq]

(Submitter supplied) Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia, characterized by deposition of extracellular amyloid-beta (Aβ) aggregates and intraneuronal hyperphosphorylated Tau. Many AD risk genes, identified in genome-wide association studies (GWAS), are expressed in microglia, the innate immune cells of the central nervous system. Specific subtypes of microglia emerged in relation to AD pathology, such as disease-associated microglia (DAMs), which increased in number with age in amyloid mouse models and in human AD cases. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
24 Samples
Download data: CSV, TXT
Series
Accession:
GSE226937
ID:
200226937
11.

APOE3Christchurch modulates tau phosphorylation and β-catenin/Wnt signaling in iPS cell-derived cerebral organoids from Alzheimer’s cases

(Submitter supplied) Alzheimer’s disease (AD) is the most common cause of dementia. A patient with the PSEN1 E280A mutation and homozygous for APOE3 Christchurch (APOE3Ch) was found to have extreme resistance to cognitive decline and tauopathy despite having high amyloid burden. We established induced pluripotent stem cell (iPS)-derived cerebral organoids from this resistant case and a non-protected control. We used CRISPR/Cas9 gene editing to remove or add APOE3Ch from these iPS cells to assess causality. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
8 Samples
Download data: H5
Series
Accession:
GSE241453
ID:
200241453
12.

Senescent cell elimination modifies features of Alzheimer’s disease in 3xTg-AD mice

(Submitter supplied) Cellular senescence has been associated with neurodegenerative disease and clearance of senescent cells using genetic or pharmaceutical strategies (senolytics) has demonstrated beneficial effects in mouse models investigating individual disease etiologies of Alzheimer’s disease (AD). However, it has remained unclear if senescent cell clearance in a mouse model exhibiting both plaque and tau pathologies modifies the disease state (3xTg). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
28 Samples
Download data: TXT
Series
Accession:
GSE231332
ID:
200231332
13.

A novel model of binge ethanol exposure reveals enhanced neurodegeneration with advanced age

(Submitter supplied) Binge drinking is rising among aged adults (>65 years of age). The distinct effects of binge ethanol exposure on neurodegeneration in the aged brain are not well described. Using our model of intermittent binge ethanol exposure in young and aged mice, we investigated how binge ethanol expoure may promote neurodegenerative diease development. Spatial transcriptomics revealed that binge ethanol exposure enriched neurodegenerative disease pathways in the aged hippocampus, including tau hyperphosphorylation and neuronal death. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL24247
4 Samples
Download data: CLOUPE, H5, MTX, TIFF, TSV
Series
Accession:
GSE236787
ID:
200236787
14.

Transcriptomic evaluation of tau and TDP-43 synergism shows tauopathy predominates.

(Submitter supplied) Cellular responses to co-morbid tau and TDP-43 preceding neurodegeneration have not been characterized. In this study, we evaluate transcriptomic changes at time-points preceding frank neuronal loss using a C. elegans model of tau and TDP-43 co-expression. We find significant differential expression and exon usage in genes enriched in multiple pathways including lipid metabolism and lysosomal degradation. more...
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26672
32 Samples
Download data: SF
Series
Accession:
GSE249339
ID:
200249339
15.

Whole organism snRNA-seq reveals systemic peripheral changes in Alzheimer’s Disease fly models

(Submitter supplied) Alzheimer's Disease (AD) is known for its profound impact on the brain, yet its systemic effects, particularly on peripheral tissues, remain underexplored. To address this gap, we utilized Drosophila, an established model for aging and neurodegeneration studies, to create the Alzheimer's Disease Fly Cell Atlas (AD-FCA). This comprehensive atlas comprises whole-organism single-nucleus transcriptomes from 219 cell types in two AD models, where adult flies express human Aβ42 or Tau exclusively in neurons. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25244
28 Samples
Download data: H5AD, TAR
Series
Accession:
GSE261656
ID:
200261656
16.

Transcriptomic analysis of bovine endometrial epithelial cells in response to interferon tau and hormone stimulation

(Submitter supplied) The embryonic loss during early stage of gestation is one of the major causes of infertility for domestic ruminants, causing huge economic losses to pasture. Maternal recognition of pregnancy and implantation are the crucial process for determining the successful establishment and development of pregnancy in cattle. The research on molecular mechanisms of pregnancy recognition will facilitate illustrating the complex process of pregnancy establishment and help to improve pregnancy outcomes. more...
Organism:
Bos taurus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19172
9 Samples
Download data: TXT
Series
Accession:
GSE253481
ID:
200253481
17.

APOE3 genotype extends lifespan in rodent models of tauopathy

(Submitter supplied) To gain insight into the role of human APOE on tau-associated neurodegeneration, we examined P301S mutant tau transgenic mice carrying humanized APOE alleles
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
21 Samples
Download data: TXT
Series
Accession:
GSE226093
ID:
200226093
18.

KCNJ2 inhibition mitigates mechanical injury in human brain organoids [scRNA-seq]

(Submitter supplied) Traumatic brain injury (TBI) strongly correlates with neurodegenerative disease. However, it remains unclear which neurodegenerative mechanisms are intrinsic to the brain itself and which strategies most potently mitigate these processes, particularly in individuals genetically predisposed to neurodegeneration. We developed a high-intensity ultrasound platform to inflict mechanical injury to iPSC-derived cortical organoids. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
2 Samples
Download data: MTX, TSV
Series
Accession:
GSE260532
ID:
200260532
19.

KCNJ2 inhibition mitigates mechanical injury in human brain organoids

(Submitter supplied) Traumatic brain injury (TBI) strongly correlates with neurodegenerative disease. However, it remains unclear which neurodegenerative mechanisms are intrinsic to the brain itself and which strategies most potently mitigate these processes, particularly in individuals genetically predisposed to neurodegeneration. We developed a high-intensity ultrasound platform to inflict mechanical injury to iPSC-derived cortical organoids. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
6 Samples
Download data: XLSX
Series
Accession:
GSE259432
ID:
200259432
20.

Gene expression profile at single cell levels of the cells from the controls and tau P251L Drosophila brain.

(Submitter supplied) Tau protein has been implicated in the pathology of Alzheimer's disease and related disorders. We CRISPR engineered an endogenous model of tauopathy by knocking in a pathogenic human tau mutation, tau P301L, in Drosophila, tau P251L KI. We used single cell RNA sequencing to identify the differentially expressed genes or pathways.
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL19132 GPL25244
6 Samples
Download data: MTX, TSV
Series
Accession:
GSE223345
ID:
200223345
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