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Items: 1 to 20 of 37

1.
Full record GDS4545

Cardiac right ventricle hypertrophy model

Analysis of right ventricle (RV) from C57BL/6 males subjected to hemoclip installation around the pulmonary artery (PA) for up to 6 weeks. PA clipping induces RV hypertrophy (RVH) while avoiding detrimental RV pressure overload. Results provide insight into the molecular basis of RV remodeling.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 protocol, 3 time, 2 tissue sets
Platform:
GPL6246
Series:
GSE30428
12 Samples
Download data: CEL
DataSet
Accession:
GDS4545
ID:
4545
2.
Full record GDS4154

Parkinson's disease: post-mortem medullary regions

Analysis of 2 regions of PD medullas: dorsal motor nucleus of the vagus (DMNV) and inferior olivary nucleus (ION). A functional magnetic resonance imaging variant was used to identify brainstem regions targeted by (DMNV) and resistant to (ION) PD. Results provide insight into molecular basis of PD.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state, 11 individual, 2 tissue sets
Platform:
GPL571
Series:
GSE19587
22 Samples
Download data: CEL, CHP
3.
Full record GDS3680

Calreticulin deficiency effect on embryonic stem cell line

Analysis of D3 embryonic stem cells lacking calreticulin (CRT). CRT is a calcium binding protein.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE13805
7 Samples
Download data: CEL
4.

Gene expression profiles in systemic sclerosis tenosynovial biopsies

(Submitter supplied) Systemic sclerosis is a connective tissue disease affecting skin and internal organs, characterized by a triad of inflammation, vasculopathy and progressive fibrosis, due to deposition of mainly type I collagen. Out of the intricate mechanisms involved in the pathogenesis of the disease, evidence indicates that TGFbeta signaling plays a central role in mediating the effects of several pro-fibrotic effectors. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
30 Samples
Download data: CEL
Series
Accession:
GSE93698
ID:
200093698
5.

Sexual Divergence in Microtubule Function: The Novel Intranasal Microtubule Targeting SKIP Normalizes Axonal Transport and Enhances Memory

(Submitter supplied) Activity-dependent neuroprotective protein (ADNP), essential for brain formation, is a frequent autism spectrum disorder (ASD)-mutated gene. ADNP associates with microtubule end binding proteins (EBs) through its SxIP motif, to regulate dendritic spine formation and brain plasticity. Here, we reveal SKIP, a novel 4 amino acid peptide representing an EB-binding site, as a replacement therapy in an outbred Adnp-deficient mouse model. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
23 Samples
Download data: TXT
Series
Accession:
GSE72664
ID:
200072664
6.

Differential expression analysis between Microadenoma and Macroadenoma in Cushing's Disease

(Submitter supplied) ACTH-dependent hypercortisolism caused by a pituitary adenoma [Cushing’s disease (CD)] is the most common cause of endogenous Cushing’s syndrome. CD is often associated with several morbidities, including hypertension, diabetes, osteoporosis/bone fractures, secondary infections, and increased cardiovascular mortality. While the majority (≈80%) of the corticotrophinomas visible on pituitary magnetic resonance imaging are microadenomas (MICs, <10 mm of diameter), some tumors are macroadenomas (MACs, ≥10 mm) with increased growth potential and invasiveness, exceptionally exhibiting malignant demeanor. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5175
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE72490
ID:
200072490
7.

IL-23 promotes immunopathology and prevents IL-13-dependent tissue repair by Ly6Clo monocytes in parasite-induced liver damage

(Submitter supplied) Background & Aims: The IL-23/IL-17 axis plays an important role in the pathogenesis of autoimmune diseases and the pathological consequences of infection. We previously showed that immunopathologic mechanisms mediated by inflammatory monocytes underlie the severe focal liver damage induced by the protozoan parasite, Entamoeba histolytica. Here, we analyze the contribution of the IL-23/IL-17 axis to the induction and subsequent recovery from parasite-induced liver damage. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
12 Samples
Download data: CEL, TXT
Series
Accession:
GSE73686
ID:
200073686
8.

Identification of differentially expressed genes in Fibrogenesis imperfecta ossium via Global microarray analysis

(Submitter supplied) Global microarray was performed from Trans-Iliac Bone biopsy from the patient with clinically characterized Fibrogensis imperfecta ossium (FIO). A 40-year-old male patient with clinically characterized Fibrogensis imperfecta ossium (FIO) includes fragility fracture with osteomalacia (Losser’s zone). On examination, his height was 158 cm, weight 47 kg, body mass index (BMI) 16.5, and his blood pressure was 120/80 mmHg. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL15207
4 Samples
Download data: CEL
Series
Accession:
GSE43861
ID:
200043861
9.

Human adult white matter progenitor cells are multipotent neuroprogenitors identical to adult hippocampal progenitors

(Submitter supplied) Adult neural progenitor cells (aNPCs) are a potential autologous cell source for cell replacement in neurologic diseases such as Parkinson’s disease or stroke or for cell-based gene therapy for neurometabolic diseases. Easy accessibility, long-term expandability and detailed characterization of NPC properties are important requisites for their future translational/clinical applications. aNPC can be isolated from different regions of the adult human brain including the accessible subcortical white matter (aNPCWM), but systematic studies comparing long-term expanded aNPCWM with aNPC from neurogenic brain regions to check for their NPC characteristics and performance are not available. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
7 Samples
Download data: CEL
Series
Accession:
GSE47921
ID:
200047921
10.

Selection of reference genes for gene expression studies related to hypoxia in cervical cancer

(Submitter supplied) The present work aimed to identify reference genes for RT-qPCR studies of hypoxia in cervical cancer. From 422 candidate reference genes selected from the literature, we used Illumina array-based expression profiles to identify 182 genes not affected by hypoxia treatment in eight cervical cancer cell lines or correlated with the hypoxia-associated dynamic contrast-enhanced magnetic resonance imaging parameter ABrix in 42 patients. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6884 GPL10558
166 Samples
Download data: TXT
Series
Accession:
GSE75034
ID:
200075034
11.

Integrative analysis of DCE-MRI and gene expression profiles in construction of a gene classifier for assessment of hypoxia-related risk of chemoradiotherapy failure in cervical cancer

(Submitter supplied) We have previously identified a prognostic 31-gene expression signature in locally advanced cervical cancer that is associated with tumor hypoxia and reflected by the dynamic contrast enhanced magnetic resonance (DCE-MR) image parameter ABrix. To bring the signature closer to clinical use, we here aimed to construct a classifier with key signature genes that retained an association to ABrix and separated the patients into groups with different hypoxia status and chemoradiotherapy outcome. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL10558 GPL6884
302 Samples
Download data: TXT
Series
Accession:
GSE72723
ID:
200072723
12.

Tissue Slice Grafts of Human Renal Cell Carcinoma: an Authentic Preclinical Model with High Engraftment Rate and Metastatic Potential

(Submitter supplied) Purpose: Discovery of curative therapies for renal cell carcinoma (RCC) is hampered by lack of authentic preclinical models. Tumorgrafts, generated by direct implantation of patient-derived tissues into mice, have demonstrated superior ability to predict therapeutic response. We evaluated “tissue slice grafts” (TSGs) as an improved tumorgraft model of RCC. Experimental Design: Cores of fresh RCC were precision-cut at 300-μm and implanted under the renal capsule of RAG2-/-γC-/- mice. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
6 Samples
Download data: TXT
Series
Accession:
GSE44548
ID:
200044548
13.

A Patient-derived In Vitro - In Vivo Preclinical Model of Renal Cell Carcinoma

(Submitter supplied) Purpose: Authentic preclinical models of renal cell carcinoma (RCC) are lacking. We aimed to establish and characterize primary RCC cultures and demonstrate the feasibility of evaluating drug responses in vitro and in vivo. Materials and Methods: Previously published methodology, with minor modifications, was used to establish, cryopreserve, and serially passage RCC cells from nephrectomy and tumorgraft specimens. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
3 Samples
Download data: TXT
Series
Accession:
GSE47356
ID:
200047356
14.

Genome-wide gene expression analysis on remote non-infarcted myocardium after treatment with Valsartan in a mouse model of myocardial infarction

(Submitter supplied) To find which genes were significantly modulated by Valsartan in non-infarcted left ventricle, 4 weeks after coronary artery ligation, and to correlate emerging modulated pathways with histology and cardiac magnetic resonance (CMR) imaging. The goal was to validate the estimation of the systolic dysfunction and of the regions preserved by pharmacological treatment performed with a CMR index. Title of the associated submitted paper: Evaluation of left ventricle function by regional fractional area change (RFAC) in a mouse model of myocardial infarction secondary to Valsartan treatment. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
17 Samples
Download data: TXT
Series
Accession:
GSE68426
ID:
200068426
15.

Noncoding RNAs in human intervertebral disc degeneration: an integrated microarray study

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Each of the SubSeries contained in this SuperSeries represents identical RNA samples used for hybridization to different array platforms.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platforms:
GPL15314 GPL19978 GPL19449
30 Samples
Download data: GPR, TIFF, TXT
Series
Accession:
GSE67567
ID:
200067567
16.

The long noncoding RNA expression profile of human intervertebral disc degeneration identified by microarray analysis

(Submitter supplied) In addition to the well-known short noncoding RNAs as miRNAs, increasing evidence suggests that long noncoding RNAs (lncRNAs) act as key regulators in a wide aspect of biologic processes. Dysregulated expression of lncRNAs has been demonstrated being implicated in a variety of human diseases. However, there is relative paucity of information regarding the role of lncRNAs in intervertebral disc degeneration (IDD) hitherto. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array; Expression profiling by array
Platform:
GPL15314
10 Samples
Download data: TIFF, TXT
Series
Accession:
GSE56081
ID:
200056081
17.

Gene expression profile of human endothelial cells with or without nanoparticles

(Submitter supplied) To understand the the effect of poly(lactic-co-glycolic acid) nanoparticles (NPs) encapsulating a fluorine contrast agent on human umbilical vein endothelial cells (HUVECs), we have employed whole genome microarray expression profiling. The NPs used in this study were prepared in our lab. HUVECs were ordered from Lonza (Cat# C2517A). HUVECs were incubated with NPs for 4 hours. After 4 h, the cells were washed couple of times to remove the NPs and gene expression profiles were detected after 20 h (total time: 24 h) and 7 d in the absence of NPs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
9 Samples
Download data: TXT
Series
Accession:
GSE51661
ID:
200051661
18.

Gene expression profile of hematopoietic stem cells (CD34+ cells) with or without nanoparticles

(Submitter supplied) To understand the the effect of poly(lactic-co-glycolic acid) nanoparticles (NPs) encapsulating a fluorine contrast agent on hematopoietic stem cells (CD34+ fraction of umbilical cord blood mononuclear cells), we have employed whole genome microarray expr
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
12 Samples
Download data: TXT
Series
Accession:
GSE51421
ID:
200051421
19.

HIC2 is a novel dosage-dependent regulator of cardiac development within the distal 22q11 deletion syndrome region

(Submitter supplied) Rationale: 22q11 deletion syndrome arises from recombination between low copy repeats on chromosome 22. Typical deletions result in hemizygosity for TBX1 associated with congenital cardiovascular disease. Deletions distal to the typically deleted region result in a similar cardiac phenotype but lack extra-cardiac features of the syndrome suggesting that a second haploinsufficient gene maps to this interval. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6096
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE56430
ID:
200056430
20.

Gene expression data from lymphoblastoid cell lines from participants in the Genetics of Microangiopathic Brain Injury study

(Submitter supplied) European-American individuals of the GENOA cohort participating in the “Genetics of Microangiopathic Brain Injury” substudy, which investigates the genetic basis of alteration in brain structure detectable by magnetic resonance imaging. This analysis investigated the association of gene expression with age (at the time of cell transformation).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5175
883 Samples
Download data: CEL
Series
Accession:
GSE49531
ID:
200049531
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