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Items: 1 to 20 of 1424216

1.
Full record GDS6177

Acute alcohol consumption effect on whole blood (control group): time course

Analysis of blood from subjects administered orange juice w/o alcohol. Blood collected at time points corresponding to collection times for the alcohol group in GDS4938. These results, together with those from GDS4938, provide insight into molecular response of blood during acute ethanol exposure.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 individual, 2 protocol, 5 time sets
Platform:
GPL570
Series:
GSE20489
25 Samples
Download data: CEL
2.
Full record GDS6100

MicroRNA-135b overexpression effect on prostate cancer cell line: time course

Analysis of LNCaP prostate cancer (PCa) cells overexpressing miRNA-135b for up to 36 hours. LNCaP cells express the androgen receptor (AR). MiRNA-135b overexpression in AR+ PCa cells results in slower growth compared to AR knockdown. Results provide insight into the basis of this slower growth.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 protocol, 3 time sets
Platform:
GPL10558
Series:
GSE57820
12 Samples
Download data
3.
Full record GDS6083

Chronic lymphocytic leukemia cells response to the neutralization of inhibitor of apoptosis proteins

Analysis of chronic lymphocytic leukemia (CLL) cells treated with BV6, a Smac mimetic. CLL is characterized by B-lymphocyte accumulation, which is attributed to defective cell death. Inhibitor of apoptosis (IAP) proteins are highly expressed in CLL cells. Smac binds to and inhibits IAP proteins.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 4 genotype/variation, 4 individual, 2 other, 2 time sets
Platform:
GPL570
Series:
GSE62533
12 Samples
Download data: CEL
DataSet
Accession:
GDS6083
ID:
6083
4.
Full record GDS6082

Sendai virus infection effect on monocytic cell line: dose response

Analysis of U937 monocytic cells infected at multiplicities of infection of 0.0002 and 0.02 with the Sendai virus. Results provide insight into the differences between the innate immune response of cells infected with a low and high concentration of virus.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 dose, 2 infection sets
Platform:
GPL10558
Series:
GSE67198
11 Samples
Download data
5.
Full record GDS6063

Influenza A effect on plasmacytoid dendritic cells

Analysis of primary plasmacytoid dendritic cells (pDC) exposed to influenza A for 8 hours ex vivo. pDCs are vital to antiviral defense, directing immune responses via secretion of interferon-alpha. Results provide insight into the regulation of the response of pDC to viral pathogens.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 5 individual, 2 infection sets
Platform:
GPL10558
Series:
GSE68849
10 Samples
Download data
6.
Full record GDS6010

Influenza virus H5N1 infection of U251 astrocyte cell line: time course

Analysis of U251 astrocyte cells infected with the influenza H5N1 virus for up to 24 hours. Results provide insight into the immune response of astrocytes to H5N1 infection.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 infection, 3 time sets
Platform:
GPL6480
Series:
GSE66597
18 Samples
Download data: TXT
7.
Full record GDS5948

Zipper-interacting protein kinase deficiency effect on coronary artery smooth muscle cells in vitro

Analysis of cultured vascular smooth muscle cells following knockdown of zipper-interacting protein kinase (ZIPK). ZIPK is phosphorylated and activated by Rho-associated kinase 1 (ROCK1). These results, together with those from GDS5659, provide further insight into ROCK1 and ZIPK functions.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL6244
Series:
GSE56819
6 Samples
Download data: CEL
8.
Full record GDS5914

YAP transcriptional regulator depletion effect on endothelial cells

Analysis of umbilical vein endothelial HUVEC cells depleted for the transcriptional regulator YAP. YAP binds to the SH3 domain of the transcriptional activator Yes. Results provide insight into the role of YAP in endothelial cell proliferation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 agent, 2 protocol sets
Platform:
GPL6244
Series:
GSE61989
12 Samples
Download data: CEL
9.
Full record GDS5913

SRPIN803 small molecule inhibitor of SRPK1 effect on retinal pigment epithelial cell line

Analysis of retinal pigment epithelial ARPE-19 cells treated with SRPIN803, a small molecule inhibitor of serine-arginine protein kinase 1 SRPK1. SRPK1 inhibition prevents pathological angiogenesis. Results provide insight into the molecular mechanisms underlying the inhibitory activity of SRPIN803.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent sets
Platform:
GPL570
Series:
GSE62947
6 Samples
Download data: CEL
DataSet
Accession:
GDS5913
ID:
5913
10.
Full record GDS5826

Multiple myeloma cell lines with acquired resistance to chemotherapeutic agent carfilzomib

Analysis of proteasome inhibitor carfilzomib-resistant multiple myeloma (MM) cell lines KMS-11/Cfz and KMS-34/Cfz, after 1 week of growth in the absence of carfilzomib. Results provide insight into the molecular mechanisms underlying the acquisition of proteasome inhibitor resistance in MM.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 cell line, 2 cell type sets
Platform:
GPL570
Series:
GSE69078
12 Samples
Download data: CEL
11.
Full record GDS5819

Metastatic breast cancer and sepsis: monocytes

Analysis of the total population of monocytes from patients with metastatic breast cancer (MBC), sepsis, or tuberculosis. Results provide insight into molecular similarities between monocytes from MBC patients and reprogrammed immunosuppressive monocytes from sepsis patients.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 disease state sets
Platform:
GPL10558
Series:
GSE65517
13 Samples
Download data
12.
Full record GDS5817

Interleukin 17A effect on monocyte-derived dendritic cells

Analysis of in vitro-generated dendritic cells (DCs) cultured with interleukin 17A (IL-17A) in the absence or presence of interferon-γ. IL-17A is involved in chronic inflammatory diseases. Results provide insight into the impact of IL-17A on DCs and the role of these DCs in inflammatory disease.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 protocol, 2 time sets
Platform:
GPL570
Series:
GSE53163
9 Samples
Download data: CEL
13.
Full record GDS5816

Methyltransferase EZH2 inhibition effect on ARID1A mutated ovarian clear cell cancer cell line

Analysis of ARID1A-mutated OVISE ovarian clear cell carcinoma (OCCC) cells restored with wild-type ARID1A or treated with GSK126, an inhibitor of epigenetic regulator EZH2. Epigenetic modifier ARID1A is often mutated in OCCC. Results provide insight into the role of epigenetic mechanisms in OCCC.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 genotype/variation sets
Platform:
GPL10558
Series:
GSE54979
9 Samples
Download data
14.
Full record GDS5815

Sunitinib effect on renal cancer xenograft tumors

Analysis of Kyoto University Renal Cancer (KURC) xenograft tumor models, KURC1, KURC2, KURC3, treated with sunitinib, a small molecule inhibitor of receptor tyrosine kinases that is used to treat RC. Results provide insight into molecular mechanisms underlying acquired sunitinib resistance in RC.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 3 disease state, 3 individual sets
Platform:
GPL6244
Series:
GSE66346
9 Samples
Download data: CEL
15.
Full record GDS5812

Staphylococcal alpha-toxin effect on airway epithelial cells

Analysis of bronchial epithelial cell lines 16HBE14o- (Hla-susceptible) and S9 (Hla-resistant) treated with S. aureus recombinant alpha-toxin (rHla) for 2 hrs. Results provide insight into molecular mechanisms underlying cell type-specific responses of airway epithelial cells to alpha-toxin.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 cell line sets
Platform:
GPL6244
Series:
GSE65018
8 Samples
Download data: CEL
16.
Full record GDS5811

TGFβ1 effect on gingival fibroblasts pretreated with TGFβ-associated kinase 1 inhibitor 5Z-7-Oxozeanol

Analysis of cultured gingival fibroblasts pre-treated with TGFβ-associated kinase 1 (TAK1) inhibitor (5Z)-7-Oxozeanol for 45 min prior to treatment with TGFβ1. Results provide insight into the extent to which TAK1 mediates fibroproliferative responses in gingival fibroblasts in response to TGFβ1.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 protocol sets
Platform:
GPL6244
Series:
GSE65069
8 Samples
Download data: CEL
17.
Full record GDS5810

Hypoxia effect on von Hippel Lindau-overexpressing renal cell carcinoma cells

Analysis of renal cell carcinoma (RCC) 786-O cells transfected with von Hippel Lindau (VHL)-overexpression vector and cultured under hypoxia conditions (1% O2) for 24 hours. Results provide insight into overlap and differences of VHL- and hypoxia-dependent molecular alterations in RCC.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 protocol, 2 stress sets
Platform:
GPL6244
Series:
GSE65168
8 Samples
Download data: CEL
18.
Full record GDS5809

Anti-leukemia drug etoposide effect on ecotropic viral integration site 1-overexpressing myeloid cells

Analysis of myeloid cell line U937 overexpressing ecotropic viral integration site 1 (EVI1) and cultured in the presence of antileukemic drug etoposide. Results provide insight into molecular mechanisms through which EVI1 confers resistance to drugs used in myeloid leukemia therapy.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 protocol sets
Platform:
GPL11532
Series:
GSE66660
8 Samples
Download data: CEL
19.
Full record GDS5805

Peptidyl-prolyl cis/trans isomerase Pin1 deficiency effect on prostate cancer cells

Analysis of prostate cancer (PC) cell lines LNCap (androgen-dependent) and DU145 (androgen-independent) following siRNA-mediated knockdown of Peptidyl-prolyl cis/trans isomerase Pin1. Results provide insight into molecular mechanisms underlying Pin1 modulation of both PC two cell lines.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 cell line, 3 protocol sets
Platform:
GPL6244
Series:
GSE67457
6 Samples
Download data: CEL
20.
Full record GDS5804

PI3K/mTOR Inhibitor NVP-BEZ235 and taxotere effects on prostate cancer xenograft tumors

Analysis of DU145 xenograft tumors in NOD/SCID mice treated with NVP-BEZ235, taxotere, or both. NVP-BEZ235 targets prostate cancer progenitor cells. Taxotere targets the bulk tumor. Results provide insight into potential biomarkers associated with cancer stem cells in these xenograft tumors.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 agent sets
Platform:
GPL570
Series:
GSE49232
4 Samples
Download data: CEL
DataSet
Accession:
GDS5804
ID:
5804
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