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Items: 1 to 20 of 9399

1.
Full record GDS5294

HIV-1 Vpr effect on monocyte-derived macrophage

Analysis of monocyte-derived macrophages infected with a recombinant adenovirus expressing the HIV-1 Vpr protein. HIV-1 Vpr is a multi-functional protein involved in HIV-1 replication and pathogenesis. Results provide further insight into the role of HIV-1 Vpr in HIV-1 infected macrophages.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 individual sets
Platform:
GPL570
Series:
GSE56591
4 Samples
Download data: CEL
2.
Full record GDS4993

Chronic simian immunodeficiency virus infection: colon, jejunum and lung

Analysis of colon, jejunum and lung from therapy-naïve, SIV-infected males. Gut and lung mucosa are important entry portals for pathogens and provide innate immune defense against infection. Results provide insight into molecular mechanisms underlying mucosal immune response during SIV infection.
Organism:
Macaca mulatta
Type:
Expression profiling by array, count, 2 infection, 3 tissue sets
Platform:
GPL3535
Series:
GSE51615
23 Samples
Download data: CEL
3.
Full record GDS4957

FOXA1 overexpression effect on prostate cancer cell line

Analysis of LNCaP prostate cancer cells overexpressing FOXA1. FOXA1 is a key member of the androgen receptor (AR) transcription factor complex. Results provide insight into the role of FOXA1 in prostate cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 protocol sets
Platform:
GPL10558
Series:
GSE49153
12 Samples
Download data
4.
Full record GDS4863

HIV envelope protein gp120 effect on activated B cells from healthy donors: time course

Temporal analysis of B cells isolated from healthy donors in response to activation in the presence of HIV-1 envelope protein gp120 with high (gp120++) or low (gp120-) affinity for integrin α4β7. Results provide insight into mechanisms by which α4β7-gp120 interaction negatively affects B cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 6 individual, 4 protocol, 4 time sets
Platform:
GPL6244
Series:
GSE49019
42 Samples
Download data: CEL
5.
Full record GDS4861

Adenovirus and lentivirus vector effects on midbrain neuroprogenitor cell cultures: time course

Temporal analysis of differentiated mNPC cultures transduced with three vectors: Helper-dependent (HD) human (HAd) and canine (CAV-2) adenoviruses and VSV-G-pseudotyped self-inactivating HIV-1 vector (LV). Results provide insight into the toxicogenomic profiles of these viral vectors in mNPCs.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 agent, 2 time sets
Platform:
GPL570
Series:
GSE47130
30 Samples
Download data: CEL
6.
Full record GDS4860

All-trans retinoic acid (ATRA) vitamin A and 1,25-dihydroxyvitamin D3 (1,25D3) vitamin D stimulated peripheral blood monocytes

Analysis of monocytes stimulated with biologically active forms of vitamin A and vitamin D. Vitamin A plays a role in host defense against Mycobacterium tuberculosis. Results provide insight into molecular mechanisms underlying the antimicrobial activities for vitamin A and vitamin D in monocytes.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 agent, 4 individual sets
Platform:
GPL570
Series:
GSE46268
12 Samples
Download data: CEL, CHP
7.
Full record GDS4786

HIV and tuberculosis co-infection: peripheral blood mononuclear cell

Analysis of PBMCs from HIV patients with and without M. tuberculosis (TB) co-infection. Co-infection with TB is a cause of death in HIV-infected individuals. Results provide insight into a molecular signature to distinguish HIV/TB co-infected patients from HIV mono-infected patients.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 infection sets
Platform:
GPL10558
Series:
GSE50834
44 Samples
Download data
8.
Full record GDS4358

Two types of HIV-associated neurocognitive impairment: brain regions

Analysis of basal ganglia, frontal cortex, and white matter from HIV patients with HIV-associated dementia (HAD) or HAD plus HIV encephalitis (HIVE). Results provide insight into molecular events of neurological impairment and inflammation associated with HIV infection in different brain regions.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 disease state, 3 tissue sets
Platform:
GPL570
Series:
GSE35864
72 Samples
Download data: CEL
9.
Full record GDS4237

Rhesus macaque type-I interferon agonist effect on peripheral whole blood of SIV-infected Sooty mangabeys: time course

Temporal analysis of whole blood from 8 naturally SIV-infected SMs treated with recombinant RM IFNalpha2-IgFc (rmIFNα2) for 16 weeks. SIV infection of SMs is typically non-pathogenic. Results provide insight into effects of experimentally-augmented IFN-I signaling in chronically SIV-infected SMs.
Organism:
Cercocebus atys; Macaca mulatta
Type:
Expression profiling by array, transformed count, 2 agent, 8 individual, 6 time sets
Platform:
GPL3535
Series:
GSE35460
47 Samples
Download data: CEL
10.
Full record GDS4236

Rapamycin-resistant diffuse large B-cell lymphoma cell lines

Analysis of diffuse large B-cell lymphoma (DLBCL) cell lines resistant to rapamycin, the prototypical mTOR (mammalian Target Of Rapamycin) inhibitor. The mTOR pathway is constitutively activated in DLBCL. Results provide insight into mechanisms of resistance to mTOR inhibition in DLBCL.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 14 cell line, 2 other sets
Platform:
GPL6244
Series:
GSE27255
14 Samples
Download data: CEL, CHP
11.
Full record GDS4235

Programmed Death 1 antibody effect on pathogenic Simian Immunodeficiency Virus infection: peripheral blood mononuclear cells

Analysis of PBMCs from SIVmac251-infected (12 wks) rhesus macaques (RMs) treated with an antibody against Programmed Death-1 (PD-1) for 14 days. Results provide insight into the molecular mechanisms by which PD-1 blockade enhances survival of SIV-infected RMs.
Organism:
Macaca mulatta
Type:
Expression profiling by array, transformed count, 3 agent, 2 infection sets
Platform:
GPL3535
Series:
GSE33933
10 Samples
Download data: CEL
12.
Full record GDS4234

Transgenic model Tg26 of HIV-Associated Nephropathy: kidney cortex

Analysis of kidney cortices from HIV-1 transgenic, FVB/N males and females (Tg26). Tg26 models the renal pathologic changes observed in human disease and is used to study HIV-associated nephropathy (HIVAN) pathogenesis. Results provide insight into the molecular mechanisms underlying HIVAN.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE35226
12 Samples
Download data: CEL, CHP
13.
Full record GDS4233

Protein kinase HIPK2 overexpression effect on Human Embryonic Kidney cells

Analysis of HEK293 cells transfected with homeo-domain interacting protein kinase 2 (HIPK2) and HIPK2-DN mutant. HIPK2 mediates renal fibrosis in 3 mouse models of renal fibrosis (Tg26, UUO, folic-acidinduced renal fibrosis). Results provide further insight into role of HIPK2 in kidney fibrosis.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 genotype/variation sets
Platform:
GPL6244
Series:
GSE35226
12 Samples
Download data: CEL, CHP
14.
Full record GDS4232

HIV infection effect on interferon alpha 2-treated monocyte-derived macrophages: time course

Temporal analysis of macrophages pretreated for 18hrs with interferon alpha 2 (IFNα2) then infected with HIV-1 (Bal strain). IFN treatment prior to in vitro HIV infection inhibits virus replication. Results provide insight into molecular mechanisms underlying this modulation of viral replication.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 infection, 2 protocol, 6 time sets
Platform:
GPL570
Series:
GSE30536
17 Samples
Download data: CEL
15.
Full record GDS4231

Antiretroviral therapy effect on brain of patients with HIV-associated neurocognitive disorders

Analysis of postmortem brain of ART-treated, HIV-1-associated neurocognitive disorders (HAND) patients. ART reduces morbidity and mortality in HIV infection, but HAND persist despite treatment. Results provide insight into ART effectiveness in brain and into molecular signatures of HAND under ART.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 disease state sets
Platform:
GPL570
Series:
GSE28160
35 Samples
Download data: CEL
16.
Full record GDS4230

Pathogenic Simian Immunodeficiency Virus infection in Rhesus macaques: colorectal tissue

Analysis of colorectal biopsies from SIV-infected Rhesus macaques (RM) and Sooty mangabeys (SM). Unlike AIDS-susceptible RMs, natural hosts such as SMs do not progress to AIDS. Results provide insight into molecular basis of immune activation following pathogenic immunodeficiency virus infections.
Organism:
Cercocebus atys; Macaca mulatta
Type:
Expression profiling by array, transformed count, 3 infection, 2 species, 3 time sets
Platform:
GPL3535
Series:
GSE29980
16 Samples
Download data: CEL
17.
Full record GDS4229

Model of HIV-associated pulmonary arterial hypertension: right superior lobe of lung

Analysis of lung from 3 month old, human immunodeficiency virus (HIV)-transgenic F344 males. The HIV-transgenics display pulmonary hypertension and pulmonary artery remodeling. Results provide insight into the molecular mechanisms underlying HIV-PAH onset and progression.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1355
Series:
GSE27393
6 Samples
Download data: CEL
18.
Full record GDS4228

HIV infection and Antiretroviral Therapy effects on mitochondria in various tissues

Analysis of PBMCs, muscle, adipose tissue from human immunodeficiency virus (HIV)-positive adults receiving nucleoside reverse transcriptase inhibitor (NRTI)-based ART. Results provide insight into molecular mechanisms underlying the divergent effects of HIV infection and ART on mitochondria in fat.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 agent, 2 disease state, 3 tissue sets
Platform:
GPL9392
Series:
GSE30310
166 Samples
Download data: CEL
19.
Full record GDS4227

Highly Active Antiretroviral Therapy (HAART) interruption effect on HIV patients: jejunal mucosa

Analysis of gut biopsies from HIV+ patients following interruption of HAART. Gut-associated lymphoid tissue (GALT) is a critical host-pathogen interaction site in HIV infection. Results provide insight into molecular basis of host response to viral rebound in GALT following HAART interruption.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state, 6 individual sets
Platform:
GPL570
Series:
GSE28177
6 Samples
Download data: CEL
20.
Full record GDS4226

Programmed Death-1-expressing CD8 T cells in healthy adult peripheral blood

Analysis of PD-1hi, PD-1lo, and naive CD8+CD3+ T cells FACS-sorted from peripheral blood of healthy adults. PD-1, a member of the CD28 family of immune modulators, is highly expressed on chronic virus-specific CD8 T cells. Results provide insight into PD-1-expressing CD8 T cells in healthy adults.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 cell type sets
Platform:
GPL570
Series:
GSE26495
16 Samples
Download data: CEL, CHP
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