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Items: 1 to 20 of 63

1.
Full record GDS5445

E3 ubiquitin ligase PARK2 depletion effect on SF539 glioma cell line

Analysis of SF539 glioma cells depleted for PARK2. PARK2 is an E3 ubiquitin ligase. Results provide insight into the role of PARK2 in the coordinate control of cyclins in cell cycle regulation and tumor suppression.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 agent sets
Platform:
GPL571
Series:
GSE50864
6 Samples
Download data: CEL
2.
Full record GDS5444

E3 ubiquitin ligase PARK2 depletion effect on SNB19 glioma cell line

Analysis of SNB19 glioma cells depleted for PARK2. PARK2 is an E3 ubiquitin ligase. Results provide insight into the role of PARK2 in the coordinate control of cyclins in cell cycle regulation and tumor suppression.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 agent sets
Platform:
GPL571
Series:
GSE50864
6 Samples
Download data: CEL
3.
Full record GDS5346

BET bromodomain inhibitor JQ1 effect on MYC-amplified medulloblastoma cell lines

Analysis of 5 MYC-amplified medulloblastoma cell lines treated with the BET bromodomain inhibitor JQ1. Cell lines derived from medulloblastoma patients. Results provide insight into the potential use of BET bromodomain inhibitors in the treatment of MYC-amplified medulloblastomas.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 5 cell line sets
Platform:
GPL6244
Series:
GSE51020
10 Samples
Download data: CEL
4.

Genetic and transcriptional variation alters cancer cell line drug response

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
11 Samples
Download data
Series
Accession:
GSE114462
ID:
200114462
5.

Genetic and transcriptional variation alters cancer cell line drug response [MCF7 strain AA]

(Submitter supplied) 10X Genomics single cell RNAseq of MCF7 cells treated with bortezomib. Human cancer cell lines are the workhorse of cancer research. While cell lines are known to evolve in culture, the extent of the resultant genetic and transcriptional heterogeneity and its functional consequences remain understudied. Here, genomic analyses of 106 cell lines grown in two laboratories revealed extensive clonal diversity. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
4 Samples
Download data: CSV
Series
Accession:
GSE114461
ID:
200114461
6.

Genetic and transcriptional variation alters cancer cell line drug response [MCF7 strain L]

(Submitter supplied) 10X Genomics single cell RNAseq of MCF7 cells Human cancer cell lines are the workhorse of cancer research. While cell lines are known to evolve in culture, the extent of the resultant genetic and transcriptional heterogeneity and its functional consequences remain understudied. Here, genomic analyses of 106 cell lines grown in two laboratories revealed extensive clonal diversity. Follow-up comprehensive genomic characterization of 27 strains of the common breast cancer cell line MCF7 uncovered rapid genetic diversification. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
3 Samples
Download data: CSV
Series
Accession:
GSE114460
ID:
200114460
7.

Genetic and transcriptional variation alters cancer cell line drug response [MCF7]

(Submitter supplied) 10X Genomics single cell RNAseq of MCF7 cells Human cancer cell lines are the workhorse of cancer research. While cell lines are known to evolve in culture, the extent of the resultant genetic and transcriptional heterogeneity and its functional consequences remain understudied. Here, genomic analyses of 106 cell lines grown in two laboratories revealed extensive clonal diversity. Follow-up comprehensive genomic characterization of 27 strains of the common breast cancer cell line MCF7 uncovered rapid genetic diversification. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
4 Samples
Download data: CSV
Series
Accession:
GSE114459
ID:
200114459
8.

Genetically-defined Diffuse Large B-cell Lymphoma Subsets Arise by Distinct Pathogenetic Mechanisms and Predicts Outcome

(Submitter supplied) We obtained gene experssion profiles of 52 newly diagnosed diffuse large B-cell lymphoma (DLBCL).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL23432
137 Samples
Download data: CEL
Series
Accession:
GSE98588
ID:
200098588
9.

Single cell RNA-seq analysis of K27M-mutant glioma

(Submitter supplied) To understand the diversity of expression states within K27M-mutant gliomas, we profiled 4058 single cells, primarily from 6 K27M-mutant gliomas, by single cell RNA-seq
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
4058 Samples
Download data: TXT
Series
Accession:
GSE102130
ID:
200102130
10.

Affymetrix SNP 6.0 array data for gastric adenocarcinoma and some matched normals

(Submitter supplied) Using data from high-density genomic profiling arrays, we investigated the profiles of somatic copy-number aberrations (SCNAs) in 659 gastric adenocarcinomas drawn approximately even numbers of Asian and Western patients with two goals in mind: (1) using the power of our large data set to detect new, and refine existing, regions of significantly recurring SCNAs; (2) determining if there exist fundamental differences in the manifestation of gastric adenocarcinoma in Asian versus Western patients that affect pattern of SCNAs. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platform:
GPL6801
111 Samples
Download data: CEL, TXT, XLSX
Series
Accession:
GSE77775
ID:
200077775
11.

Effect of SF3B1 suppression in cancer cells with different SF3B1 copy-number levels

(Submitter supplied) Breast cancer cell lines containing stable dox inducible shRNAs targeting SF3B1 were profiled by RNA sequencing. We determined the effect of gene expression and splicing changes before and after knocking down SF3B1 in cell lines with normal copy number (SF3B1neutral) or partial copy loss (SF3B1loss) cell lines
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
16 Samples
Download data: GCT
Series
Accession:
GSE81978
ID:
200081978
12.

Escape from X-Inactivation Tumor Suppressor (EXITS) genes contribute to sex bias

(Submitter supplied) In this manuscript, we described male-biased mutations in chrX genes in cancer. In this RNA-seq experiment we tested the transcriptional consequences of shRNA knockdown of one of those genes, CNKSR2
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
9 Samples
Download data: XLSX
Series
Accession:
GSE85462
ID:
200085462
13.

Genomic Landscape of Schwannoma

(Submitter supplied) Epigenome analysis of schwannoma tumor samples
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL13534
125 Samples
Download data: IDAT
Series
Accession:
GSE79009
ID:
200079009
14.

The Somatic Landscape of Schwannoma

(Submitter supplied) To identify the role of the SH3PXD2A-HTRA1 fusion on gene expression in Schwann cells
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
6 Samples
Download data: CEL
Series
Accession:
GSE81145
ID:
200081145
15.

MYBQKI overexpression in mouse NSC, and suppression of wild type Qk

(Submitter supplied) Samples are mouse neural stem cells overexpressing eGFP, MYBtr, MYBQKI5, MYBQKI6 and MYBQKI6 with suppression of Qk (or LacZ)
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL18233
26 Samples
Download data: CEL
Series
Accession:
GSE75796
ID:
200075796
16.

Studying relative gene expression in Head and Neck (HNSCC) tumor under diverse culture conditions

(Submitter supplied) To compare the gene expression profile in HNSCC tumor cultured under various conditions
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14550
4 Samples
Download data: TXT
Series
Accession:
GSE63545
ID:
200063545
17.

Studying relative gene expression in primary and xenograft CRC samples

(Submitter supplied) To compare the gene expression profile in primary human colorectal cancer samples and samples passaged in mice for two generations
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14550
8 Samples
Download data: TXT
Series
Accession:
GSE63544
ID:
200063544
18.

Methylation data from medulloblastoma tumor samples

(Submitter supplied) Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large cohort of SHH-MBs across all age groups by sequencing, DNA methylation and expression profiling. Our data show that most adults but only half of the pediatric patients with SHH-MB will respond to SMO inhibition as predicted by molecular analysis of the primary tumor and tested in the SHH-xenografts, demonstrating that the next generation of SMO-inhibitor trials should be based on these predictive biomarkers. more...
Organism:
Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL13534
83 Samples
Download data: TXT
Series
Accession:
GSE49576
ID:
200049576
19.

Methylation profiling data from medulloblastoma tumor samples

(Submitter supplied) Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large cohort of SHH-MBs across all age groups by sequencing, DNA methylation and expression profiling. Our data show that most adults but only half of the pediatric patients with SHH-MB will respond to SMO inhibition as predicted by molecular analysis of the primary tumor and tested in the SHH-xenografts, demonstrating that the next generation of SMO-inhibitor trials should be based on these predictive biomarkers. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL13534
46 Samples
Download data: TXT
Series
Accession:
GSE49377
ID:
200049377
20.

Gene expression profiling of 151 pediatric low-grade gliomas

(Submitter supplied) We performed gene expression profiling on 151 paraffin-embedded PLGGs from different locations, ages, histological subtypes as well as BRAF genetic status We also compared molecular differences to normal pediatric brain expression profiles to observe whether those patterns were mirrored in normal brain expression.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5474
166 Samples
Download data: TXT
Series
Accession:
GSE60898
ID:
200060898
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