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Items: 1 to 20 of 696

1.
Full record GDS5430

Ethanol effect on lymphoblastoid cell lines from alcoholics

Analysis of lymphoblastoid cell lines (LCLs), obtained from alcoholics, after treatment with ethanol in vitro. Results provide insight into the feasibility of using LCLs to study the molecular consequences of exposure to alcohol.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 disease state, 2 gender, 42 individual sets
Platform:
GPL570
Series:
GSE52553
84 Samples
Download data: CEL, CHP
2.
Full record GDS4879

Chronic high-level alcohol consumption effect on brain: post-mortem hippocampus

Analysis of post-mortem hippocampus of chronic alcoholics (CAs). Chronic high-level alcohol consumption leads to decreased white matter and inhibition of neurogenesis. Results provide insight into molecular mechanisms that may play a role in the risk for alcoholism.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state, 2 gender sets
Platform:
GPL6244
Series:
GSE44456
39 Samples
Download data: CEL
3.
Full record GDS4412

Dietary fatty acid composition effect on vastus lateralis muscle

Analysis of skeletal muscle (SM) from insulin resistant men 4 hrs after consumption of meals high in saturated FA (SFA), monounsaturated FA (MUFA), or polyunsaturated FA (PUFA). Results provide insight into mechanisms underlying effects of FA composition on SM FA handling and insulin sensitivity.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 10 individual, 3 protocol, 2 time sets
Platform:
GPL6244
Series:
GSE31901
56 Samples
Download data: CEL
DataSet
Accession:
GDS4412
ID:
4412
4.
Full record GDS3072

Alcohol sensitivity model

Analysis of alcohol resistant and sensitive strains. Strains generated by artificial selection for alcohol sensitivity over multiple generations. Results provide insight into the molecular basis of alcohol sensitivity.
Organism:
Drosophila melanogaster
Type:
Expression profiling by array, count, 2 gender, 2 other, 3 strain sets
Platform:
GPL1322
Series:
GSE7614
24 Samples
Download data: CEL, CHP
5.
Full record GDS2485

Alcohol sensitive and tolerant populations

Analysis of alcohol-sensitive Canton S animals immediately following ethanol exposure and a population of Canton S animals that developed tolerance 2 hours after ethanol exposure. Results provide insight into the underlying cellular and physiological mechanisms that respond to alcohol exposure.
Organism:
Drosophila melanogaster
Type:
Expression profiling by array, count, 2 agent, 3 protocol, 2 strain sets
Platform:
GPL1322
Series:
GSE5382
15 Samples
Download data
6.
Full record GDS2447

Transcriptional profiling of tobacco smokers versus controls

Analysis of lymphoblast cell lines derived from six subjects with active nicotine dependence. Depression susceptibility, nicotine dependence, alcohol dependence, and cannabis dependence have correlated genetic and environmental diatheses. Results provide insight into complex behaviour disorders.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL1426
Series:
GSE6264
15 Samples
Download data
DataSet
Accession:
GDS2447
ID:
2447
7.
Full record GDS2191

Bipolar disorder: orbitofrontal cortex

Analysis of postmortem orbitofrontal cortex from 10 adults with bipolar disorder. Results provide insight into the pathophysiology of the disease.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL96
Series:
GSE5389
21 Samples
Download data: CEL
DataSet
Accession:
GDS2191
ID:
2191
8.
Full record GDS2190

Bipolar disorder: dorsolateral prefrontal cortex

Analysis of postmortem dorsolateral prefrontal cortex from 30 adults with bipolar disorder. Results provide insight into the pathophysiology of the disease.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL96
Series:
GSE5388
61 Samples
Download data: CEL
DataSet
Accession:
GDS2190
ID:
2190
9.
Full record GDS1610

Inbred Long Sleep and Inbred Short Sleep model of ethanol sensitivity: cerebellum (MG-430B)

Comparison of cerebella of Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) animals. ILS animals are more sensitive than ISS animals to ethanol. Initial sensitivity to ethanol is a predictor of alcohol abuse. Results provide insight into the molecular basis of differential ethanol sensitivity.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 strain sets
Platform:
GPL340
Series:
GSE3071
4 Samples
Download data: CEL, EXP
10.
Full record GDS1609

Inbred Long Sleep and Inbred Short Sleep model of ethanol sensitivity: cerebellum (MG-430A)

Comparison of cerebella of Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) animals. ILS animals are more sensitive than ISS animals to ethanol. Initial sensitivity to ethanol is a predictor of alcohol abuse. Results provide insight into the molecular basis of differential ethanol sensitivity.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 strain sets
Platform:
GPL339
Series:
GSE3071
4 Samples
Download data: CEL, EXP
11.

Astrocyte-specific transcriptome responses to chronic ethanol consumption

(Submitter supplied) Purpose: Traditional whole-tissue sequencing approaches do not fully capture brain cell-type specific effects of chronic alcohol. Therefore, the purpose of this study was to identify the specific transcriptome alterations in astrocytes due to chronic alcohol. Methods: We performed RNA-sequencing on astrocytes isolated from the prefrontal cortex (PFC) of C57BL/6J mice following chronic every-other-day alcohol consumption. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
45 Samples
Download data: TXT
Series
Accession:
GSE92457
ID:
200092457
12.

DNA methylation signatures of chronic alcohol dependence in purified CD3+ T-cells of patients undergoing alcohol treatment

(Submitter supplied) Several studies have shown an association of alcohol dependence with DNA methylation, suggesting that environmentally-induced changes on epigenomic variation may play an important role in alcohol dependence. In the present study, we analyzed genome-wide DNA methylation profiles of purified CD3+ T-cells from pre- and post-treatment alcohol dependent patients, as well as closely matched healthy controls. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL13534
71 Samples
Download data: IDAT
Series
Accession:
GSE98876
ID:
200098876
13.

A systems approach implicates a brain mitochondrial oxidative homeostasis co-expression network in genetic vulnerability to alcohol withdrawal

(Submitter supplied) Differential gene expression between mouse distal chromsome 1 congenic and background and reciprocal congenic and background Genetic factors significantly affect vulnerability to alcohol dependence (alcoholism). We previously identified a quantitative trait locus on chromosome 1 (Adw1) with a large effect on predisposition to alcohol physiological dependence and associated withdrawal following both chronic and acute alcohol exposure in mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
32 Samples
Download data: IDAT, TXT
Series
Accession:
GSE89281
ID:
200089281
14.

Gene expression analysis of MCF12A human breast cultures exposed to ethanol or acetaldehyde [4 weeks]

(Submitter supplied) Alcoholism is associated with breast cancer incidence and progression, and moderate chronic consumption of ethanol is a risk factor. The mechanisms involved in alcohol's oncogenic effects are unknown, but it has been speculated that they may be mediated by acetaldehyde. Here, we use the immortalized normal human epithelial breast cell line MCF-12A to determine whether short- or long-term exposure to ethanol or to acetaldehyde, using in vivo compatible ethanol concentrations, induces their oncogenic transformation and/or the acquisition of epithelial mesenchymal transition (EMT). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6244 GPL11532
5 Samples
Download data: CEL
Series
Accession:
GSE76951
ID:
200076951
15.

Gene expression analysis of MCF12A human breast cultures exposed to ethanol or acetaldehyde [1 week]

(Submitter supplied) Alcoholism is associated with breast cancer incidence and progression, and moderate chronic consumption of ethanol is a risk factor. The mechanisms involved in alcohol's oncogenic effects are unknown, but it has been speculated that they may be mediated by acetaldehyde. Here, we use the immortalized normal human epithelial breast cell line MCF-12A to determine whether short- or long-term exposure to ethanol or to acetaldehyde, using in vivo compatible ethanol concentrations, induces their oncogenic transformation and/or the acquisition of epithelial mesenchymal transition (EMT). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
4 Samples
Download data: CEL
Series
Accession:
GSE76950
ID:
200076950
16.

Alterations to the Synaptic Transcriptome in Response to Ethanol-Induced Behavioral Sensitization in DBA/2J Mice

(Submitter supplied) Alcoholism is a complex neurological disorder characterized by loss of control in limiting intake, and progressive compulsion to seek and consume ethanol. Prior studies have suggested that the characteristic behaviors associated with escalation of drug use are caused, at least in part, by ethanol-evoked changes in gene expression affecting synaptic plasticity. Implicit in this hypothesis is a dependence on new protein synthesis and remodeling at the synapse. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
24 Samples
Download data: XLSX
Series
Accession:
GSE73018
ID:
200073018
17.

HuMiChip2 for Strain Level Identification and Functional Profiling of Human Microbiomes

(Submitter supplied) HuMiChip2 was applied to analyze perform both strain-level identification and the functional profiling of human gut microbiomes from alcoholic cirrhosis patients and healthy individuals with alcohol abuse.
Organism:
human metagenome
Type:
Other
Platform:
GPL22376
18 Samples
Download data: TXT
Series
Accession:
GSE86162
ID:
200086162
18.

Blood, adipose and muscle samples taken from monozygotic twin pairs with age range 32-37

(Submitter supplied) FITFATTWIN study identified from the FinnTwin16 Cohort, which is a population based, longitudinal study of Finnish twins born between October 1974 and December 1979. The participants had no chronic disease affecting the ability to exercise, no acute disease, and no drug or alcohol abuse.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL20932
61 Samples
Download data: CEL
Series
Accession:
GSE73142
ID:
200073142
19.

Integrated Analysis of Dysregulated lncRNA and mRNA Expression profiles of myocardial sleevesof pulmonary veins in atrial fibrillation

(Submitter supplied) Atrial fibrillation (AF) is currently the most prevalent arrhythmia worldwide.Recent clinical data implicate the additional contribution of non-coding RNAs in the pathogenesis of AF,which include microRNAs(miRNAs), endogenous small interfering RNAs, PIWIinteracting RNAs, and lncRNA. Notably, a growing number of lncRNAs have been implicated in disease etiology, although an association with AF has not been reported. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17586
12 Samples
Download data: CEL
Series
Accession:
GSE76899
ID:
200076899
20.

Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brain [miRNA 3.0]

(Submitter supplied) We performed a global analysis of extracellular miRNAs in the serum of human subjects diagnosed with Alcohol Use Disorder (AUD) to identify robust biomarkers of early brain damage or dysfunction. This was performed in a set of 20 AUD subjects and 10 age-matched controls. They were subjected to comprehensive medical, neuropsychological and neuroimaging tests, followed by comparison of miRNA levels found in peripheral blood serum. more...
Organism:
Homo sapiens; synthetic construct
Type:
Non-coding RNA profiling by array
Platform:
GPL16384
30 Samples
Download data: CEL
Series
Accession:
GSE71537
ID:
200071537
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