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Items: 13

1.

ChIP-exo of human KRAB-ZNFs transduced in HEK 293T cells and KAP1 in hES H1 cells

(Submitter supplied) Encoded in the hundreds by the human genome, KRAB-containing zinc finger proteins (KRAB-ZFPs) constitute a rapidly evolving family of transcription factors with largely undefined functions. Here, by a combination of phylogenetic and genomic approaches, we retrace the evolutionary history of KRAB-ZFP genes and define the genomic targets of their human products. Through in silico analysis of 207 vertebrate genomes and chromatin immunoprecipitation / deep sequencing characterization of 257 human KRAB-ZFPs, we identify the root of the family in an early Devonian ancestor of tetrapods, describe its diversity amongst these species, and reveal that the majority of its human members primarily recognize transposable elements. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL16791
237 Samples
Download data: BED
Series
Accession:
GSE78099
ID:
200078099
2.

ChIP-seq from HEK293 (ENCSR519HKW)

(Submitter supplied) eGFP-ZNF264 ChIP-seq on human HEK293 cells. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
2 Samples
Download data: BED, BIGBED, BIGWIG, TXT
Series
Accession:
GSE91834
ID:
200091834
3.

ChIP-seq from HEK293 (ENCSR110ZVM)

(Submitter supplied) Input ChIP-seq on eGFP-ZNF264 tagged human HEK293 cells. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
1 Sample
Download data: TXT
Series
Accession:
GSE91497
ID:
200091497
4.

Multiparameter functional diversity of human C2H2 zinc finger proteins

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
252 Samples
Download data: TXT
Series
Accession:
GSE76496
ID:
200076496
5.

Identification of in vivo binding sites of human GFP-tagged C2H2-ZF proteins

(Submitter supplied) The largest and most diverse class of eukaryotic transcription factors contain Cys2-His2 zinc fingers (C2H2-ZFs), each of which typically binds a DNA nucleotide triplet within a larger binding site. Frequent recombination and diversification of their DNA-contacting residues suggests that these zinc fingers play a prevalent role in adaptive evolution. Very little is known about the function and evolution of the vast majority of C2H2-ZFs, including whether they even bind DNA. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
160 Samples
Download data: TXT
Series
Accession:
GSE76494
ID:
200076494
6.

Identification of in vivo binding sites of human C2H2-ZF proteins

(Submitter supplied) The largest and most diverse class of eukaryotic transcription factors contain Cys2-His2 zinc fingers (C2H2-ZFs), each of which typically binds a DNA nucleotide triplet within a larger binding site. Frequent recombination and diversification of their DNA-contacting residues suggests that these zinc fingers play a prevalent role in adaptive evolution. Very little is known about the function and evolution of the vast majority of C2H2-ZFs, including whether they even bind DNA. more...
Organism:
synthetic construct
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL15228
39 Samples
Download data: BED
Series
Accession:
GSE58341
ID:
200058341
7.

Large-scale characterization of DNA binding landscape of eukaryotic C2H2 zinc fingers

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Cys2-His2 zinc finger (C2H2-ZF) proteins represent the largest class of putative human transcription factors (TFs). However, it is unknown whether most C2H2-ZFs even bind DNA, or what sequences they bind. Using a combination of bacterial one-hybrid (B1H) assays, protein-binding microarrays (PBMs), and ChIP-seq, we have found that most natural C2H2-ZFs bind DNA both in vitro and in vivo. more...
Organism:
synthetic construct
Type:
Other; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL15228 GPL11260
734 Samples
Download data: BED, TXT
Series
Accession:
GSE52523
ID:
200052523
8.

ZNF264

Organism:
Homo sapiens
Source name:
transduced 293T cell line
Platform:
GPL16791
Series:
GSE78099
Download data: BED
Sample
Accession:
GSM2466509
ID:
302466509
9.

ChIP-seq from HEK293 (ENCLB999NOH)

Organism:
Homo sapiens
Source name:
Homo sapiens HEK293 immortalized cell line derived from HEK293 stably expressing N-terminal eGFP-ZNF264 fusion protein
Platform:
GPL11154
Series:
GSE91834
Download data: BED, BIGBED, BIGWIG, TXT
Sample
Accession:
GSM2423601
ID:
302423601
10.

ChIP-seq from HEK293 (ENCLB883JKC)

Organism:
Homo sapiens
Source name:
Homo sapiens HEK293 immortalized cell line derived from HEK293 stably expressing N-terminal eGFP-ZNF264 fusion protein
Platform:
GPL11154
Series:
GSE91834
Download data: BED, BIGBED, BIGWIG, TXT
Sample
Accession:
GSM2423600
ID:
302423600
11.

ChIP-seq from HEK293 (ENCLB240IEM)

Organism:
Homo sapiens
Source name:
Homo sapiens HEK293 immortalized cell line derived from HEK293 stably expressing N-terminal eGFP-ZNF264 fusion protein
Platform:
GPL11154
Series:
GSE91497
Download data: TXT
Sample
Accession:
GSM2423033
ID:
302423033
12.

ChIP-seq of GFP-tagged ZNF264 in HEK293 cells [ZNF264_rep1]

Organism:
Homo sapiens
Source name:
HEK293 cells expressing GFP-tagged protein
Platform:
GPL11154
Series:
GSE76494 GSE76496
Download data: TXT
Sample
Accession:
GSM2026744
ID:
302026744
13.

ChIP-seq of GFP-tagged ZNF264 in HEK293 cells

Organism:
synthetic construct
Source name:
HEK293 cells expressing GFP-tagged protein
Platform:
GPL15228
Series:
GSE52523 GSE58341
Download data: BED
Sample
Accession:
GSM1407649
ID:
301407649
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