GSM956232[Accession] - GEO DataSets

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Items: 4

Select item 2000391151.

UNG shapes the specificity of AID-induced somatic hypermutation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Other

Platform:: GPL11002
28 Samples

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Accession:: GSE39115

ID:: 200039115

PubMed Full text in PMC Similar studies

Select item 2000391082.

UNG shapes the specifity of AID-induced somatic hypermutation in non B cells

(Submitter supplied) Secondary diversification of antibodies through somatic hypermutation (SHM) and class switch recombination (CSR) is a critical component of the immune response. Activation-induced deaminase (AID) initiates both processes by deaminating cytosine residues in immunoglobulin genes. The resulting U:G mismatch can be processed by alternative pathways to give rise to a mutation (SHM) or a DNA double-strand break (CSR). more...