GSM866780[Accession] - GEO DataSets

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Items: 3

Select item 2000353611.

JMJD3 is needed to regulate TGF beta responsive genes.

(Submitter supplied) Neural development requires crosstalk between signaling pathways and chromatin. In this study, we demonstrate that neurogenesis is promoted by an interplay between the TGFβ pathway and the H3K27me3 histone demethylase (HDM) JMJD3. Genome-wide analysis showed that JMJD3 is targeted to gene promoters by Smad3 in neural stem cells (NSCs) and is essential to activate TGFβ-responsive genes. In vivo experiments in chick spinal cord revealed that the generation of neurons promoted by Smad3 is dependent on JMJD3 HDM activity. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10333
12 Samples

Download data: TXT

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Accession:: GSE35361

ID:: 200035361

Select item 1000103332.

Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Feature Number version)

(Submitter supplied) Mouse Content Refresh 44k Arrays of this design have barcodes that begin with 16026655 or 2526655. Orientation: Features are numbered numbered Left-to-Right, Top-to-Bottom as scanned by an Agilent scanner (barcode on the left, DNA on the back surface, scanned through the glass), matching the FeatureNum output from Agilent's Feature Extraction software. The ID column represents the Agilent Feature Extraction feature number. more...