GSM846067[Accession] - GEO DataSets

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Items: 4

Select item 2000348861.

Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity [expression profiling]

(Submitter supplied) The TET family of FE(II) and 2-oxoglutarate-dependent enzymes (Tet1/2/3) promote DNA demethylation by converting 5-methylcytosine to 5-hydroxymethylcytosine (5hmC), which they further oxidize into 5-formylcytosine and 5-carboxylcytosine. Tet1 is robustly expressed in mouse embryonic stem cells (mESCs) and has been implicated in mESC maintenance. Here we demonstrate that, unlike genetic deletion, RNAi-mediated depletion of Tet1 in mESCs led to a significant reduction in 5hmC and loss of mESC identity. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL14661
8 Samples

Download data: CEL

Series

Accession:: GSE34886

ID:: 200034886

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000342672.

Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Methylation profiling by high throughput sequencing

Platforms:: GPL14661 GPL9250
12 Samples

Download data: BED, CEL, WIG

Series

Accession:: GSE34267

ID:: 200034267

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000146613.

[Mouse430_2_Mm_EntrezG] Affymetrix GeneChip Mouse Genome 430 2.0 Array [Brainarray Version 13]

(Submitter supplied) This is identical to GPL1261 but a custom CDF environment was used to extract data [Brainarray Version 13, Mouse4302_Mm_ENTREZG]. CDF and other files can be downloaded at: (see web link below).