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Items: 3

1.

Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity

(Submitter supplied) Lipid nanoparticles (LNPs) for mRNA delivery have advanced significantly, but LNP-mediated DNA delivery still faces clinical challenges. This study compared various LNP formulations for delivering DNA-encoded biologics, assessing their expression efficacy and the protective immunity generated by LNP-encapsulated DNA in different models. The LNP formulation used in Moderna’s Spikevax mRNA vaccine (LNP-M) demonstrated a stable nanoparticle structure, high expression efficiency, and low toxicity. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
20 Samples
Download data: CSV, TAR
Series
Accession:
GSE272803
ID:
200272803

PubMed

2.

Illumina NovaSeq 6000 (Mus musculus)

Organism:
Mus musculus
18084 Series
748756 Samples
Download data
Platform
Accession:
GPL24247
ID:
100024247

3.

LNP-M/Ctrl, scRNA-seq-TCR (Spleen)

Organism:
Mus musculus
Source name:
Spleen
Platform:
GPL24247
Series:
GSE272803
Download data: CSV
Sample
Accession:
GSM8412801
ID:
308412801

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db=gds|term=GSM8412801[Accession]|query=1|qty=2|blobid=MCID_6878a8fdb8a45d1382672d74|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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