GSM7949443[Accession] - GEO DataSets

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Items: 4

Select item 2002495411.

Extracellular niche and tumor microenvironment enhance the impact of KRAS inhibitors in pancreatic cancer models.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Other; Expression profiling by high throughput sequencing

Platforms:: GPL24247 GPL30173 GPL11154
47 Samples

Download data: DCC, H5, RESULTS

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Accession:: GSE249541

ID:: 200249541

PubMed Full text in PMC Similar studies

Select item 2002495372.

Extracellular niche and tumor microenvironment enhance the impact of KRAS inhibitors in pancreatic cancer models [CRISPR]

(Submitter supplied) Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease for which new therapeutic interventions are needed. Here, we assessed the cellular response to pharmacological KRAS inhibition, targeting the central oncogenic factor in PDAC. In a panel of PDAC cell lines, pharmaceutical inhibition of the KRASG12D allele with MRTX1133 yields variable efficacy in the suppression of cell growth and downstream gene expression programs in 2D culture. more...