GSM7918805[Accession] - GEO DataSets

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Items: 4

Select item 2002486941.

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL24247 GPL16417
35 Samples

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Accession:: GSE248694

ID:: 200248694

PubMed

Select item 2002486902.

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells I

(Submitter supplied) The gut microbiota promotes immune system development in early life, but the interactions between the gut metabolome and immune cells in the neonatal gut remains largely undefined. Here, we demonstrate that the neonatal gut is uniquely enriched with neurotransmitters, including serotonin; specific gut bacteria produce serotonin directly while downregulating monoamine oxidase A to limit serotonin breakdown. more...