GSM7807646[Accession] - GEO DataSets

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Items: 4

Select item 2002441231.

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL24676 GPL30991 GPL24247
103 Samples

Download data: DCC, H5, TAR

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Accession:: GSE244123

ID:: 200244123

Select item 2002441222.

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single cell RNA seq on RPM-GFP and RPMA ONB tumors]

(Submitter supplied) The olfactory epithelium relies on active neuron regeneration from basal stem cells and is susceptible to olfactory neuroblastoma (ONB), a rare, aggressive tumor of unclear origins. Here, we establish a new, highly-penetrant, genetically-engineered mouse model of ONB with alterations in Rb1/Trp53/Myc that exhibit a NEUROD1+ immature neuronal state. ASCL1 loss leads to emergence of non-neuronal histopathologies, including a POU2F3+ microvillar-like state. more...