GSM7577794[Accession] - GEO DataSets

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Items: 4

Select item 2002368251.

Acquisition of suppressive function by CD4+ conventional T cells limits anti-tumor immunity driven by Treg depletion.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL13112 GPL24247
27 Samples

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Accession:: GSE236825

ID:: 200236825

PubMed Full text in PMC Similar studies

Select item 2002368242.

Acquisition of suppressive function by CD4+ conventional T cells limits anti-tumor immunity driven by Treg depletion [scRNA-seq]

(Submitter supplied) Regulatory T (Treg) cells are essential for immune homeostasis but inhibit immune rejection of cancer. Strategies to disrupt Treg-mediated cancer immunosuppression have been met with limited clinical success, but the underlying mechanisms for this failure are poorly understood. By modeling Treg-targeted immunotherapy in mice, we find that a subset of CD4+ Foxp3- conventional T (Tconv) cells with potent suppressive function undergoes activation and expansion upon depletion of Foxp3+ Treg cells and limits therapeutic efficacy. more...