GSM7290872[Accession] - GEO DataSets

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Items: 4

Select item 2002315671.

Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
45 Samples

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Series

Accession:: GSE231567

ID:: 200231567

PubMed Full text in PMC Similar studies

Select item 2002315662.

Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation [ChIP-seq]

(Submitter supplied) Chromatin integrates extracellular signals to regulate gene expression and, therefore, tightly controls development. Mutations in histone genes, including H3.3 and H4, were recently identified in children with developmental disorders characterized by intellectual disability and dysmorphic facial features1–7. However, the mechanistic and functional roles of these de novo, heterozygous germline mutations remain largely unknown. more...