GSM6589666[Accession] - GEO DataSets

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Items: 4

Select item 2002136011.

PPARg and C/EBPa response to acute cold stress in brown adipose tissue

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL24247 GPL19057
72 Samples

Download data: BW, NARROWPEAK, TAB

Series

Accession:: GSE213601

ID:: 200213601

PubMed Full text in PMC Similar studies

Select item 2002136002.

PPARg and C/EBPa response to acute cold stress in brown adipose tissue [ChIP-Seq]

(Submitter supplied) Brown adipose tissue (BAT) has the ability to burn calories as heat. BAT thermogenesis is an attractive way to combat obesity pandemic. However, the transcriptional network resulting in lipid synthesis to oxidation shift during thermogenesis is not completely understood. Here, we report the regulation of two master regulators of adipogenesis, PPARγ and C/EBPα, during acute cold stress in BAT. We found PPARγ dissociated from DNA in a third of its binding sites and these included cebpa enhancers leading to decreased C/EBPα. more...