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Items: 4

1.

Comparative cofactor screens reveal the influence of transactivation domains and core promoters on the mechanisms of transcription.

(Submitter supplied) Eukaryotic transcription factors (TFs) activate gene expression by recruiting cofactors to promoters. However, the relationships between TFs, promoters and their associated cofactors remain poorly understood. Here, we combine GAL4-transactivation assays with comparative CRISPR-Cas9 screens to identify the cofactors required by nine different TFs in human cells. Using this dataset, we associate key TFs with their cofactors, classify cofactors as ubiquitous or specific, discover novel transcriptional co-dependencies and demonstrate that certain TFs use the tail 2 and kinase submodules of Mediator to potentiate transcriptional elongation. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platform:
GPL18573
165 Samples
Download data: BW, CSV, NARROWPEAK, TXT
Series
Accession:
GSE198944
ID:
200198944

PubMed Similar studies

2.

Comparative cofactor screens reveal the influence of transactivation domains and core promoters on the mechanisms of transcription [RNA-seq]

(Submitter supplied) Eukaryotic transcription factors (TFs) activate gene expression by recruiting cofactors to promoters. However, the relationships between TFs, promoters and their associated cofactors remain poorly understood. Here, we combine GAL4-transactivation assays with comparative CRISPR-Cas9 screens to identify the cofactors required by nine different TFs in human cells. Using this dataset, we associate key TFs with their cofactors, classify cofactors as ubiquitous or specific, discover novel transcriptional co-dependencies and demonstrate that certain TFs use the tail 2 and kinase submodules of Mediator to potentiate transcriptional elongation. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
1 Sample
Download data: CSV, TXT
Series
Accession:
GSE198942
ID:
200198942

3.

Illumina NextSeq 500 (Homo sapiens)

Organism:
Homo sapiens
13818 Series
368222 Samples
Download data
Platform
Accession:
GPL18573
ID:
100018573

4.

Safe NoTNF and Safe TNF

Organism:
Homo sapiens
Source name:
K562 cells
Platform:
GPL18573
Series:
GSE198942 GSE198944
Download data: CSV, TXT
Sample
Accession:
GSM5961441
ID:
305961441

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db=gds|term=GSM5961441[Accession]|query=1|qty=2|blobid=MCID_691a77b5140b71006afc97d3|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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