GSM5727336[Accession] - GEO DataSets

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Items: 4

Select item 2001906561.

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL21103 GPL16791
19 Samples

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Accession:: GSE190656

ID:: 200190656

PubMed Full text in PMC Similar studies

Select item 2001906552.

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia [mouse_RNA-seq]

(Submitter supplied) Detailed genomic and epigenomic analyses of MECOM (the MDS1 and EVI1 complex locus) have revealed that inversion or translocation of chromosome 3 at MECOM drive inv(3)/t(3;3) myeloid leukemias and revealed MECOM germline mutations in patients with MECOM-associated bone marrow failure syndromes. Here we identify a novel, previously unannotated oncogenic RNA-splicing derived isoform of EVI1 which is frequently present in inv(3)/t(3;3) AML and directly contributes to leukemic transformation. more...