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Items: 4

1.

Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array
11 related Platforms
455 Samples
Download data: CEL, TXT
Series
Accession:
GSE22778
ID:
200022778
2.

Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (Leukemia cell lines)

(Submitter supplied) We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressive leukemia. MSI2 is over-expressed in human myeloid leukemia, and expression levels directly correlate with decreased patient survival, thereby defining MSI2 expression as a novel prognostic marker in acute myeloid leukemia (AML). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
8 Samples
Download data: TXT
Series
Accession:
GSE22775
ID:
200022775
3.

Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)

(Submitter supplied) This multi-pack (4X44K) formatted microarray represents a compiled view of the human genome as it is understood today. The sequence information used to design this product was derived from a broad survey of well known sources such as RefSeq, Goldenpath, Ensembl, Unigene and others. The resulting view of the human genome covers 41K unique genes and transcripts which have been verified and optimized by alignment to the human genome assembly and by Agilent's Empirical Validation process. more...
Organism:
Homo sapiens
10 DataSets
840 Series
3 Related Platforms
15438 Samples
Download data: TXT
Platform
Accession:
GPL4133
ID:
100004133
4.

Human acute myeloid leukaemia cell line THP-I.2

Organism:
Homo sapiens
Source name:
THP-I, MSI2 shRNA (channel 1) THP-I, control (channel 2)
Platform:
GPL4133
Series:
GSE22775 GSE22778
Download data: TXT
Sample
Accession:
GSM563217
ID:
300563217
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