GSM5578006[Accession] - GEO DataSets

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Items: 4

Select item 2001808711.

NFI factors repress fetal hemoglobin in adult erythorid cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL18573 GPL30173
48 Samples

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Series

Accession:: GSE180871

ID:: 200180871

PubMed Full text in PMC Similar studies

Select item 2001808602.

NFI factors repress fetal hemoglobin in adult erythorid cells [CUT&RUN]

(Submitter supplied) The mechanisms by which the fetal type b-globin-like genes HBG1 and HBG2 are silenced in adult erythroid precursor cells is a basic biology question in human development. Reversal of such mechanisms is beneficial for b hemoglobinopathies, such as sickle cell disease (SCD). A CRISPR-Cas9 genetic screen uncovered two members of the NFI transcription factor family – NFIA and NFIX – as novel HBG1/2 repressors. more...