GSM5514724[Accession] - GEO DataSets

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Items: 4

Select item 2001819511.

H3K4 Methylation in β-cells prevents transcriptional downregulation and variance associated with type 2 diabetes.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL25537 GPL19057
30 Samples

Download data: BW, MTX

Series

Accession:: GSE181951

ID:: 200181951

PubMed Full text in PMC Similar studies

Select item 2001819492.

H3K4 Methylation in β-cells prevents transcriptional downregulation and variance associated with type 2 diabetes [ChIP-seq]

(Submitter supplied) Insufficient insulin release by β-cells is the primary etiology in type 2 diabetes (T2D) and coincides with impaired expression of genes essential to β-cell function, but drivers of gene expression dysregulation are not well resolved. We find that H3K4me3 peak breadth correlates with gene expression dysregulation in T2D. Using an adult β-cell Dpy30-KO mouse model, we show that global reduction of H3K4 methylation causes downregulation of genes also downregulated in T2D. more...