(Submitter supplied) IRF4 is critical for differentiation of various CD4+ effector T cells, such as T helper 1 (Th1), Th2, and Th17 subsets, through interaction with BATF-containing AP-1 heterodimers. A major BATF heterodimeric partner, JunB, regulates Th17 differentiation, but the role of JunB in other CD4+ effector T subsets is not fully understood. Here we demonstrate that JunB is essential for accumulation of Th1 and Th2 cells, as well as Th17 cells, both in vitro and in vivo.
more...- Organism:
- Mus musculus
- Type:
- Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
- Platforms:
- GPL21103 GPL24247
- 28 Samples
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