GSM5209148[Accession] - GEO DataSets

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Items: 4

Select item 2001695551.

Embryonic lumenogenesis is controlled by selective mRNA decay triggered by LIN28A relocation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL17021 GPL21103
146 Samples

Download data: BED, SF

Series

Accession:: GSE169555

ID:: 200169555

PubMed

Select item 2001695472.

Embryonic lumenogenesis is controlled by selective mRNA decay triggered by LIN28A relocation [iCLIP]

(Submitter supplied) The naïve pluripotent epiblast cells become polarized into a rosette-like structure, followed by irreversible transition into primed pluripotency during one of the fastest morphological switches termed lumenogenesis. This requires rapid decay of pluripotency-associated mRNAs, but the underlying mechanism remains unknown. Guided by machine learning and metabolic RNA sequencing, we identified RNA binding proteins (RBPs), especially LIN28A, as primary mRNA decay factors. more...