GSM5089946[Accession] - GEO DataSets

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Items: 4

Select item 2001669641.

PARP inhibition induces cytotoxicity in mESCs by activating endogenous retroviruses.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

Platform:: GPL19057
16 Samples

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Accession:: GSE166964

ID:: 200166964

PubMed Full text in PMC Similar studies

Select item 2001669632.

Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation

(Submitter supplied) Poly(ADP-ribose) polymerases (PARP1 and PARP2) contribute to DNA base excision repair (BER) and DNA demethylation and has been implicated in epigenetic programming in early mammalian development. Recently, proteomic analyses identified BER proteins to be covalently poly-ADP-ribosylated by PARPs. The role of this posttranslational modification in the BER process is unknown. Here, we show that PARP1 senses AP-sites and SSBs generated during TET-TDG mediated active DNA demethylation and covalently attaches PAR to each BER protein engaged. more...