GSM4955260[Accession] - GEO DataSets

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Items: 4

Select item 2001626621.

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Hematopoietic stem cells (HSCs) exhibit considerable cell-intrinsic changes with age. Here, we performed an integrated analysis of transcriptome and chromatin accessibility of aged HSCs and downstream progenitors. Alterations in chromatin accessibility preferentially took place in HSCs with aging, which gradually resolved with differentiation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18480
123 Samples

Download data: BW, CSV, H5, NARROWPEAK, TBI, TSV, TXT

Series

Accession:: GSE162662

ID:: 200162662

PubMed Full text in PMC Similar studies

Select item 2001626072.

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells (RNA-seq)

(Submitter supplied) Hematopoietic stem cells (HSCs) exhibit considerable cell-intrinsic changes with age. Here, we performed an integrated analysis of transcriptome and chromatin accessibility of aged HSCs and downstream progenitors. Alterations in chromatin accessibility preferentially took place in HSCs with aging, which gradually resolved with differentiation. Differentially open accessible regions (open DARs) in aged HSCs showed enrichment of binding motifs of the STAT, ATF, and CNC family transcription factors that are activated in response to external stresses, and most of them comprised active, primed , and inactive enhancers. more...