GSM4912387[Accession] - GEO DataSets

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Items: 4

Select item 2001616761.

Identifying non-genetic determinants of malignant clonal fitness at single cell resolution

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: synthetic construct; Mus musculus

Type:: Expression profiling by high throughput sequencing; Other; Methylation profiling by high throughput sequencing

Platforms:: GPL19424 GPL19057 GPL24247
271 Samples

Download data: BED, MTX, SEG, TSV, VCF

Series

Accession:: GSE161676

ID:: 200161676

PubMed Similar studies

Select item 2001616572.

Identifying non-genetic determinants of malignant clonal fitness at single cell resolution (primary leukaemia barcode-seq)

(Submitter supplied) All cancers emerge following a period of clonal selection and subsequent clonal expansion. Whilst the evolutionary principles imparted by genetic intra-tumour heterogeneity (ITH) are becoming increasingly clear, little is known about the non-genetic mechanisms that contribute to ITH and malignant clonal fitness. Using SPLINTR, a synthetic expressed barcoding strategy, in three clinically relevant mouse models of acute myeloid leukaemia (AML) we find that malignant clonal dominance is a stable and heritable property that is facilitated by the repression of antigen presentation and the increased expression of Slpi, a leukocyte protease inhibitor that has not previously been characterised in AML. more...