GSM4889022[Accession] - GEO DataSets

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Items: 4

Select item 2001610561.

ATAC-seq, ChIP-seq and RNA-seq studies in myoblasts lacking Hira

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL21103 GPL19057
20 Samples

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Accession:: GSE161056

ID:: 200161056

PubMed Full text in PMC Similar studies

Select item 2001610542.

Genome-wide chromatin state in myoblasts lacking Hira [ChIP-seq]

(Submitter supplied) The epigenetic mechanisms coordinating the maintenance of adult cellular lineages and the inhibition of alternative cell fates are poorly understood. Here we show that targeted ablation of the histone chaperone HIRA in myogenic cells leads to extensive transcriptional modifications consistent with a major role in maintaining skeletal muscle cellular identity. Conditional ablation of HIRA in muscle stem cells of adult mice compromised their capacity to regenerate and self-renew, leading to tissue repair failure. more...