GSM447505[Accession] - GEO DataSets

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Items: 4

Select item 2000244101.

IL13 and CCL2 Drive Disease in an Inflammatory Subset of Scleroderma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platforms:: GPL7202 GPL6480
44 Samples

Download data: GPR

Series

Accession:: GSE24410

ID:: 200024410

Analyze with GEO2R

Select item 2000179142.

IL13 and CCL2 Drive Disease in an Inflammatory Subset of Scleroderma [cGVHD]

(Submitter supplied) Scleroderma is a lethal and currently irreversible autoimmune disease characterized by widespread tissue fibrosis and vasculopathy. Using cross-species comparative gene expression profiling we show that murine sclerodematous graft-versus-host disease (sclGVHD) approximates an “inflammatory” subset of human scleroderma and that both diseases demonstrate activation of the IL13 cytokine pathway. We report that both host myeloid cells expressing type I and II activated macrophage markers and graft T-cells produce IL13 and that host mice deficient in either IL13 or IL4Rα, an IL13 signal transducer, are protected from disease. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
28 Samples

Download data: GPR

Series

Accession:: GSE17914

ID:: 200017914

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000072023.

Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)

(Submitter supplied) Designed to truly represent all known genes in the mouse genome and their resulting transcripts, Agilent's Whole Mouse Genome Oligo – 4X44K microarray is comprised of 41,534 60-mer oligonucleotide probes representing over 41,000 mouse genes and transcripts. Content for this microarray was generated from leading public databases, including RefSeq, RIKEN, NIA, Ensembl, RIKEN, UCSC Goldenpath, and Unigene. more...