GSM4417000[Accession] - GEO DataSets

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Items: 4

Select item 2001470961.

mTORC1 and B cell survival signal regulate formation of memory precursors in the germinal center

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18480
24 Samples

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Accession:: GSE147096

ID:: 200147096

PubMed Full text in PMC Similar studies

Select item 2001470952.

mTORC1 and B cell survival signal regulate formation of memory precursors in the germinal center [2]

(Submitter supplied) A still unanswered question is what drives the small fraction of activated germinal center (GC) B cells that survive to become long-lived quiescent memory B cells. We found here that a small population of light zone GC cells (CD38intBcl6hi/intEfnb1+) with lower mTORC1 activity favored the memory B cell fate. Constitutively high mTORC1 activity led to defects in formation of the CD38intBcl6hi/intEfnb1+ cells; conversely, decreasing mTORC1 activity resulted in relative enrichment of this memory-prone GC population over the recycling-prone one. more...