GSM4007593[Accession] - GEO DataSets

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Items: 4

Select item 2001354511.

SS18 is a phase-separation protein relocating from pluripotent to somatic loci during mESC differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL16417 GPL24247 GPL19057
43 Samples

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Accession:: GSE135451

ID:: 200135451

PubMed Full text in PMC Similar studies

Select item 2001353952.

SS18 is a phase-separation protein relocating from pluripotent to somatic loci during mESC differentiation [ATAC-Seq]

(Submitter supplied) The transition from pluripotent to somatic states marks a critical checkpoint in mammalian development. How this is regulated remains largely unresolved. Here we report the identification of SS18 by whole genome CRISPR screen as a checkpoint regulator. SS18 regulates pluripotent to somatic transition or PST by relocating from pluripotent loci to somatic ones accompanied by corresponding chromatin closing-opening and remodeling of SS18-centric protein complexes. more...