GSM4002724[Accession] - GEO DataSets

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Items: 4

Select item 2001352861.

Epigenetic basis for monocyte dysfunction in acute-on-chronic liver failure and alcoholic hepatitis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Other; Expression profiling by high throughput sequencing

Platform:: GPL24676
29 Samples

Download data: BIGWIG, NARROWPEAK

Series

Accession:: GSE135286

ID:: 200135286

PubMed Similar studies

Select item 2001352842.

Epigenetic basis for monocyte dysfunction in acute-on-chronic liver failure and alcoholic hepatitis [ATAC-seq]

(Submitter supplied) BACKGROUND/ AIMS: Severe forms of alcoholic liver disease are associated with increased susceptibility to infections largely due to immune dysfunction. In this study, we analyze the phenotypic, molecular and functional profiles of the mononuclear phagocyte system of patients with cirrhosis, severe alcoholic hepatitis (sAH) or acute-on-chronic liver failure (ACLF). RESULTS: sAH and ACLF patients display a severe impairment of the TH1-promoting IL-12p70/IFNgamma/CXCL10 axis. more...